Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly

The extreme rarity of asexual vertebrates in nature is generally explained by genomic decay due to absence of meiotic recombination, thus leading to extinction of such lineages. We explore features of a vertebrate asexual genome, the Amazon molly, Poecilia formosa, and find few signs of genetic dege...

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Detalles Bibliográficos
Autores: Warren, Wesley C., García Pérez, Raquel, 1989-, Xu, Sen, Lampert, Kathrin P., Chapolin, Domitille, Stöck, Matthias, Loewe, Laurence, Lu, Yuan, Kuderna, Lukas, 1989-, Minx, Patrick, Montague, Michael J., Tomlinson, Chad, Hillier, LeDeana W., Murphy, Daniel N., Wang, John, Wang, Zhongwei, Macias Garcia, Constantino, Thomas, Gregg C. W., Volff, Jean-Nicolas, Farias, Fabiana, Aken, Bronwen, Walter, Ronald B., Pruitt, Kim D., Marquès i Bonet, Tomàs, 1975-, Hahn, Matthew W., Kneitz, Susanne, Lynch, Michael, Schartl, Manfred
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/33849
Acceso en línea:http://hdl.handle.net/10230/33849
http://dx.doi.org/10.1038/s41559-018-0473-y
Access Level:acceso abierto
Palabra clave:Evolució (Biologia)
Genètica evolutiva
Genòmica -- Evolució
Descripción
Sumario:The extreme rarity of asexual vertebrates in nature is generally explained by genomic decay due to absence of meiotic recombination, thus leading to extinction of such lineages. We explore features of a vertebrate asexual genome, the Amazon molly, Poecilia formosa, and find few signs of genetic degeneration but unique genetic variability and ongoing evolution. We uncovered a substantial clonal polymorphism and, as a conserved feature from its interspecific hybrid origin, a 10-fold higher heterozygosity than in the sexual parental species. These characteristics seem to be a principal reason for the unpredicted fitness of this asexual vertebrate. Our data suggest that asexual vertebrate lineages are scarce not because they are at a disadvantage, but because the genomic combinations required to bypass meiosis and to make up a functioning hybrid genome are rarely met in nature.