Drug weaponry to fight against SARS-CoV-2

The current outbreak of SARS-CoV-2 virus has caused a large increase in mortality and morbidity associated with respiratory diseases. Huge efforts are currently ongoing to develop a vaccine against this virus. However, alternative approaches could be considered in the fight against this disease. Amo...

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Detalles Bibliográficos
Autores: Cabezón Navarro, María Elena|||0000-0002-6177-5016, Arechaga Iturregui, Ignacio María
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/20582
Acceso en línea:http://hdl.handle.net/10902/20582
Access Level:acceso abierto
Palabra clave:Coronavirus
SARS-CoV-2
Covid-19
Spike
Drugs
ACE-2
Polymorphisms
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spelling Drug weaponry to fight against SARS-CoV-2Cabezón Navarro, María Elena|||0000-0002-6177-5016Arechaga Iturregui, Ignacio MaríaCoronavirusSARS-CoV-2Covid-19SpikeDrugsACE-2PolymorphismsThe current outbreak of SARS-CoV-2 virus has caused a large increase in mortality and morbidity associated with respiratory diseases. Huge efforts are currently ongoing to develop a vaccine against this virus. However, alternative approaches could be considered in the fight against this disease. Among other strategies, structural-based drug design could be an effective approach to generate specific molecules against SARS-CoV-2, thus reducing viral burden in infected patients. Here, in addition to this structural approach, we also revise several therapeutic strategies to fight against this viral threat. Furthermore, we report ACE-2 genetic polymorphic variants affecting residues involved in close contacts with SARS-CoV-2 that might be associated to different infection risks. These analyses could provide valuable information to predict the course of the disease.Frontiers MediaUniversidad de Cantabria20202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/20582Frontiers in molecular biosciences 2020; 7: 204reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/205822026-06-02T12:39:31Z
dc.title.none.fl_str_mv Drug weaponry to fight against SARS-CoV-2
title Drug weaponry to fight against SARS-CoV-2
spellingShingle Drug weaponry to fight against SARS-CoV-2
Cabezón Navarro, María Elena|||0000-0002-6177-5016
Coronavirus
SARS-CoV-2
Covid-19
Spike
Drugs
ACE-2
Polymorphisms
title_short Drug weaponry to fight against SARS-CoV-2
title_full Drug weaponry to fight against SARS-CoV-2
title_fullStr Drug weaponry to fight against SARS-CoV-2
title_full_unstemmed Drug weaponry to fight against SARS-CoV-2
title_sort Drug weaponry to fight against SARS-CoV-2
dc.creator.none.fl_str_mv Cabezón Navarro, María Elena|||0000-0002-6177-5016
Arechaga Iturregui, Ignacio María
author Cabezón Navarro, María Elena|||0000-0002-6177-5016
author_facet Cabezón Navarro, María Elena|||0000-0002-6177-5016
Arechaga Iturregui, Ignacio María
author_role author
author2 Arechaga Iturregui, Ignacio María
author2_role author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Coronavirus
SARS-CoV-2
Covid-19
Spike
Drugs
ACE-2
Polymorphisms
topic Coronavirus
SARS-CoV-2
Covid-19
Spike
Drugs
ACE-2
Polymorphisms
description The current outbreak of SARS-CoV-2 virus has caused a large increase in mortality and morbidity associated with respiratory diseases. Huge efforts are currently ongoing to develop a vaccine against this virus. However, alternative approaches could be considered in the fight against this disease. Among other strategies, structural-based drug design could be an effective approach to generate specific molecules against SARS-CoV-2, thus reducing viral burden in infected patients. Here, in addition to this structural approach, we also revise several therapeutic strategies to fight against this viral threat. Furthermore, we report ACE-2 genetic polymorphic variants affecting residues involved in close contacts with SARS-CoV-2 that might be associated to different infection risks. These analyses could provide valuable information to predict the course of the disease.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/20582
url http://hdl.handle.net/10902/20582
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Frontiers in molecular biosciences 2020; 7: 204
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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