Emerging role of glial cells in the control of body weight
Glia are the most abundant cell type in the brain and are indispensible for the normal execution of neuronal actions. They protect neurons from noxious insults and modulate synaptic transmission through affectation of synaptic inputs, release of glial transmitters and uptake of neurotransmitters fro...
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2012 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/663787 |
| Acceso en línea: | http://hdl.handle.net/10486/663787 https://dx.doi.org/10.1016/j.molmet.2012.07.001 |
| Access Level: | acceso abierto |
| Palabra clave: | Astrocytes Gliosis Hypothalamus Metabolic control Obesity Medicina |
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Emerging role of glial cells in the control of body weightGarcía-Cáceres, CristinaFuente-Martín, EstherArgente Oliver, JesúsChowen, Julie AnnAstrocytesGliosisHypothalamusMetabolic controlObesityMedicinaGlia are the most abundant cell type in the brain and are indispensible for the normal execution of neuronal actions. They protect neurons from noxious insults and modulate synaptic transmission through affectation of synaptic inputs, release of glial transmitters and uptake of neurotransmitters from the synaptic cleft. They also transport nutrients and other circulating factors into the brain thus controlling the energy sources and signals reaching neurons. Moreover, glia express receptors for metabolic hormones, such as leptin and insulin, and can be activated in response to increased weight gain and dietary challenges. However, chronic glial activation can be detrimental to neurons, with hypothalamic astrocyte activation or gliosis suggested to be involved in the perpetuation of obesity and the onset of secondary complications. It is now accepted that glia may be a very important participant in metabolic control and a possible therapeutical target. Here we briefly review this rapidly advancing fieldElsevierDepartamento de PediatríaFacultad de Medicina20122012-12-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/663787https://dx.doi.org/10.1016/j.molmet.2012.07.001reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6637872026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
Emerging role of glial cells in the control of body weight |
| title |
Emerging role of glial cells in the control of body weight |
| spellingShingle |
Emerging role of glial cells in the control of body weight García-Cáceres, Cristina Astrocytes Gliosis Hypothalamus Metabolic control Obesity Medicina |
| title_short |
Emerging role of glial cells in the control of body weight |
| title_full |
Emerging role of glial cells in the control of body weight |
| title_fullStr |
Emerging role of glial cells in the control of body weight |
| title_full_unstemmed |
Emerging role of glial cells in the control of body weight |
| title_sort |
Emerging role of glial cells in the control of body weight |
| dc.creator.none.fl_str_mv |
García-Cáceres, Cristina Fuente-Martín, Esther Argente Oliver, Jesús Chowen, Julie Ann |
| author |
García-Cáceres, Cristina |
| author_facet |
García-Cáceres, Cristina Fuente-Martín, Esther Argente Oliver, Jesús Chowen, Julie Ann |
| author_role |
author |
| author2 |
Fuente-Martín, Esther Argente Oliver, Jesús Chowen, Julie Ann |
| author2_role |
author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Pediatría Facultad de Medicina |
| dc.subject.none.fl_str_mv |
Astrocytes Gliosis Hypothalamus Metabolic control Obesity Medicina |
| topic |
Astrocytes Gliosis Hypothalamus Metabolic control Obesity Medicina |
| description |
Glia are the most abundant cell type in the brain and are indispensible for the normal execution of neuronal actions. They protect neurons from noxious insults and modulate synaptic transmission through affectation of synaptic inputs, release of glial transmitters and uptake of neurotransmitters from the synaptic cleft. They also transport nutrients and other circulating factors into the brain thus controlling the energy sources and signals reaching neurons. Moreover, glia express receptors for metabolic hormones, such as leptin and insulin, and can be activated in response to increased weight gain and dietary challenges. However, chronic glial activation can be detrimental to neurons, with hypothalamic astrocyte activation or gliosis suggested to be involved in the perpetuation of obesity and the onset of secondary complications. It is now accepted that glia may be a very important participant in metabolic control and a possible therapeutical target. Here we briefly review this rapidly advancing field |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012 2012-12-01 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10486/663787 https://dx.doi.org/10.1016/j.molmet.2012.07.001 |
| url |
http://hdl.handle.net/10486/663787 https://dx.doi.org/10.1016/j.molmet.2012.07.001 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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1869408634651279360 |
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15,301603 |