Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by 18 F-FDG PET in patients with a recent ischemic stroke

18 F-fluorodeoxyglucose positron emission tomography (18 F-FDG PET) identifies carotid plaque inflammation and predicts stroke recurrence. Our aim was to evaluate the performance of soluble low-density lipoprotein receptor-related protein 1 (sLRP1) as an indicator of carotid plaque inflammation. A p...

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Detalles Bibliográficos
Autores: García Rodríguez, Jesús Eduardo|||0000-0002-7758-6789, Camps-Renom, Pol|||0000-0001-6587-6271, Puig Calvó, Núria|||0000-0001-8235-4934, Fernández León, Alejandro|||0000-0002-1010-9451, Aguilera-Simón, Ana|||0000-0003-1428-8212, Benitez Amaro, Aleyda|||0000-0002-1106-3125, Solé, Arnau|||0009-0007-6517-6188, Viladés Medel, David|||0000-0002-3638-9703, Sánchez Quesada, José Luis|||0000-0003-0224-591X, Martí-Fàbregas, Joan|||0000-0001-9229-8649, Jiménez Xarrié, Elena|||0000-0003-3567-0672, Benitez, Sonia|||0000-0003-3565-0743, Llorente-Cortés, Vicenta|||0000-0002-0067-7201
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:280596
Acceso en línea:https://ddd.uab.cat/record/280596
https://dx.doi.org/urn:doi:10.1186/s12967-022-03867-w
Access Level:acceso abierto
Palabra clave:Soluble LRP1
18 F-FDG PET
Carotid atherosclerosis
Ischemic stroke recurrence
Vascular inflammation
Descripción
Sumario:18 F-fluorodeoxyglucose positron emission tomography (18 F-FDG PET) identifies carotid plaque inflammation and predicts stroke recurrence. Our aim was to evaluate the performance of soluble low-density lipoprotein receptor-related protein 1 (sLRP1) as an indicator of carotid plaque inflammation. A prospective study was conducted among adult patients with recent (< 7 days) anterior circulation ischemic stroke and at least one atherosclerotic plaque in the ipsilateral internal carotid artery. Patients underwent an early (< 15 days from inclusion) 18 F-FDG PET, and the maximum standardized uptake value (SUVmax) within the plaque was measured. sLRP1 levels were measured in plasma samples by ELISA. The association of sLRP1 with SUVmax was assessed using bivariate and multivariable linear regression analyses. Hazard ratios (HR) were estimated with Cox regression to evaluate the association between circulating sLRP1 and stroke recurrence. The study was conducted with 64 participants, of which 57.8% had ≥ 50% carotid stenosis. The multivariable linear and logistic regression analyses showed that sLRP1 was independently associated with (i) SUVmax within the plaque (β = 0.159, 95% CI 0.062-0.257, p = 0.002) and (ii) a probability of presenting SUVmax ≥ 2.85 g/mL (OR = 1.31, 95% CI 1.00-1.01, p = 0.046), respectively. Participants with stroke recurrence showed higher sLRP1 levels at baseline [6447 ng/mL (4897-11163) vs. 3713 ng/mL (2793-4730); p = 0.018]. sLRP1 was independently associated with carotid plaque inflammation as measured by 18 F-FDG PET in patients with recent ischemic stroke and carotid atherosclerosis. The online version contains supplementary material available at 10.1186/s12967-022-03867-w.

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