Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: The European prospective mother-child study (NewGeneris)

Background: Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents. Objectives: We examined the associations between prenatal exposure to acrylamide and birth outcomes in a pros...

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Autores: Sunyer Deu, Jordi, Pedersen, Marie, Stedingk, Hans von, Botsivali, Maria, Agramunt, Silvia, Alexander, Jan, Brunborg, Gunnar, Chatzi, Leda, Fleming, Sarah, Fthenou, Eleni, Granum, Berit, Gutzkow, Kristine B., Hardie, Laura J., Knudsen, Lisbeth E., Kyrtopoulos, Sosterios A., Mendez, Michelle A., Merlo, Domenico Franco, Nielsen, Jeanette K., Rydberg, Per, Segerbäck, Dan, Wright, John, Törnqvist, Margareta, Kleinjans, Jos C., Kogevinas, Manolis, NewGeneris Consortium
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/23369
Acceso en línea:http://hdl.handle.net/10230/23369
http://dx.doi.org/10.1289/ehp.1205327
Access Level:acceso abierto
Palabra clave:Infants -- Alimentació
Embaràs
Disruptors endocrins
Biomarker
Children
Diet
Intrauterine growth restriction
In utero exposure
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spelling Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: The European prospective mother-child study (NewGeneris)Sunyer Deu, JordiPedersen, MarieStedingk, Hans vonBotsivali, MariaAgramunt, SilviaAlexander, JanBrunborg, GunnarChatzi, LedaFleming, SarahFthenou, EleniGranum, BeritGutzkow, Kristine B.Hardie, Laura J.Knudsen, Lisbeth E.Kyrtopoulos, Sosterios A.Mendez, Michelle A.Merlo, Domenico FrancoNielsen, Jeanette K.Rydberg, PerSegerbäck, DanWright, JohnTörnqvist, MargaretaKleinjans, Jos C.Kogevinas, ManolisNewGeneris ConsortiumInfants -- AlimentacióEmbaràsDisruptors endocrinsBiomarkerChildrenDietIntrauterine growth restrictionIn utero exposureBackground: Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents. Objectives: We examined the associations between prenatal exposure to acrylamide and birth outcomes in a prospective European mother–child study. Methods: Hemoglobin (Hb) adducts of acrylamide and its metabolite glycidamide were measured in cord blood (reflecting cumulated exposure in the last months of pregnancy) from 1,101 singleton pregnant women recruited in Denmark, England, Greece, Norway, and Spain during 2006–2010. Maternal diet was estimated through food-frequency questionnaires. Results: Both acrylamide and glycidamide Hb adducts were associated with a statistically significant reduction in birth weight and head circumference. The estimated difference in birth weight for infants in the highest versus lowest quartile of acrylamide Hb adduct levels after adjusting for gestational age and country was –132 g (95% CI: –207, –56); the corresponding difference for head circumference was –0.33 cm (95% CI: –0.61, –0.06). Findings were similar in infants of nonsmokers, were consistent across countries, and remained after adjustment for factors associated with reduced birth weight. Maternal consumption of foods rich in acrylamide, such as fried potatoes, was associated with cord blood acrylamide adduct levels and with reduced birth weight. Conclusions: Dietary exposure to acrylamide was associated with reduced birth weight and head circumference. Consumption of specific foods during pregnancy was associated with higher acrylamide exposure in utero. If confirmed, these findings suggest that dietary intake of acrylamide should be reduced among pregnant women.The NewGeneris (Newborns and Genotoxic exposure risks) study was funded by the European Union (EU Contract FOOD-CT-2005-016320). The study was also supported by grants obtained locally, including the Swedish Cancer and Allergy Foundation and the Swedish Research Council Formas, the National Institute for Health Research, UK (programme grant RP-PG-0407-10044), the Norwegian Ministry of Health, the Norwegian Ministry of Education and Research, the Norwegian Research Council/FUGE (grant 151918/S10), the EU funded HiWATE (contract Food-CT-2006-036224), the U.S. National Institutes of Health (NIH)/National Institute of Environmental Health Sciences (contract NO-ES-75558), and the U.S. NIH/National Institute of Neurological Disorders and Stroke (grant 1 UO1 NS 047537-01). M.P. holds a Juan de la Cierva postdoctoral fellowship awarded from the Spanish Ministry of Science and Innovation (JCI-2011-09479)National Institute of Environmental Health Sciences (NIEHS)201520152012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/23369http://dx.doi.org/10.1289/ehp.1205327reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésEnvironmental Health Perspectives. 2012; 120(12): 1739-1745info:eu-repo/grantAgreement/EC/FP6/016320info:eu-repo/grantAgreement/EC/FP6/036224info:eu-repo/grantAgreement/ES/3PN/JCI2011-09479Reproduced with permission from Environmental Health Perspectivesinfo:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/233692026-06-12T07:21:37Z
dc.title.none.fl_str_mv Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: The European prospective mother-child study (NewGeneris)
title Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: The European prospective mother-child study (NewGeneris)
spellingShingle Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: The European prospective mother-child study (NewGeneris)
Sunyer Deu, Jordi
Infants -- Alimentació
Embaràs
Disruptors endocrins
Biomarker
Children
Diet
Intrauterine growth restriction
In utero exposure
title_short Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: The European prospective mother-child study (NewGeneris)
title_full Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: The European prospective mother-child study (NewGeneris)
title_fullStr Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: The European prospective mother-child study (NewGeneris)
title_full_unstemmed Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: The European prospective mother-child study (NewGeneris)
title_sort Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: The European prospective mother-child study (NewGeneris)
dc.creator.none.fl_str_mv Sunyer Deu, Jordi
Pedersen, Marie
Stedingk, Hans von
Botsivali, Maria
Agramunt, Silvia
Alexander, Jan
Brunborg, Gunnar
Chatzi, Leda
Fleming, Sarah
Fthenou, Eleni
Granum, Berit
Gutzkow, Kristine B.
Hardie, Laura J.
Knudsen, Lisbeth E.
Kyrtopoulos, Sosterios A.
Mendez, Michelle A.
Merlo, Domenico Franco
Nielsen, Jeanette K.
Rydberg, Per
Segerbäck, Dan
Wright, John
Törnqvist, Margareta
Kleinjans, Jos C.
Kogevinas, Manolis
NewGeneris Consortium
author Sunyer Deu, Jordi
author_facet Sunyer Deu, Jordi
Pedersen, Marie
Stedingk, Hans von
Botsivali, Maria
Agramunt, Silvia
Alexander, Jan
Brunborg, Gunnar
Chatzi, Leda
Fleming, Sarah
Fthenou, Eleni
Granum, Berit
Gutzkow, Kristine B.
Hardie, Laura J.
Knudsen, Lisbeth E.
Kyrtopoulos, Sosterios A.
Mendez, Michelle A.
Merlo, Domenico Franco
Nielsen, Jeanette K.
Rydberg, Per
Segerbäck, Dan
Wright, John
Törnqvist, Margareta
Kleinjans, Jos C.
Kogevinas, Manolis
NewGeneris Consortium
author_role author
author2 Pedersen, Marie
Stedingk, Hans von
Botsivali, Maria
Agramunt, Silvia
Alexander, Jan
Brunborg, Gunnar
Chatzi, Leda
Fleming, Sarah
Fthenou, Eleni
Granum, Berit
Gutzkow, Kristine B.
Hardie, Laura J.
Knudsen, Lisbeth E.
Kyrtopoulos, Sosterios A.
Mendez, Michelle A.
Merlo, Domenico Franco
Nielsen, Jeanette K.
Rydberg, Per
Segerbäck, Dan
Wright, John
Törnqvist, Margareta
Kleinjans, Jos C.
Kogevinas, Manolis
NewGeneris Consortium
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Infants -- Alimentació
Embaràs
Disruptors endocrins
Biomarker
Children
Diet
Intrauterine growth restriction
In utero exposure
topic Infants -- Alimentació
Embaràs
Disruptors endocrins
Biomarker
Children
Diet
Intrauterine growth restriction
In utero exposure
description Background: Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents. Objectives: We examined the associations between prenatal exposure to acrylamide and birth outcomes in a prospective European mother–child study. Methods: Hemoglobin (Hb) adducts of acrylamide and its metabolite glycidamide were measured in cord blood (reflecting cumulated exposure in the last months of pregnancy) from 1,101 singleton pregnant women recruited in Denmark, England, Greece, Norway, and Spain during 2006–2010. Maternal diet was estimated through food-frequency questionnaires. Results: Both acrylamide and glycidamide Hb adducts were associated with a statistically significant reduction in birth weight and head circumference. The estimated difference in birth weight for infants in the highest versus lowest quartile of acrylamide Hb adduct levels after adjusting for gestational age and country was –132 g (95% CI: –207, –56); the corresponding difference for head circumference was –0.33 cm (95% CI: –0.61, –0.06). Findings were similar in infants of nonsmokers, were consistent across countries, and remained after adjustment for factors associated with reduced birth weight. Maternal consumption of foods rich in acrylamide, such as fried potatoes, was associated with cord blood acrylamide adduct levels and with reduced birth weight. Conclusions: Dietary exposure to acrylamide was associated with reduced birth weight and head circumference. Consumption of specific foods during pregnancy was associated with higher acrylamide exposure in utero. If confirmed, these findings suggest that dietary intake of acrylamide should be reduced among pregnant women.
publishDate 2012
dc.date.none.fl_str_mv 2012
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/23369
http://dx.doi.org/10.1289/ehp.1205327
url http://hdl.handle.net/10230/23369
http://dx.doi.org/10.1289/ehp.1205327
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Environmental Health Perspectives. 2012; 120(12): 1739-1745
info:eu-repo/grantAgreement/EC/FP6/016320
info:eu-repo/grantAgreement/EC/FP6/036224
info:eu-repo/grantAgreement/ES/3PN/JCI2011-09479
dc.rights.none.fl_str_mv Reproduced with permission from Environmental Health Perspectives
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reproduced with permission from Environmental Health Perspectives
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Institute of Environmental Health Sciences (NIEHS)
publisher.none.fl_str_mv National Institute of Environmental Health Sciences (NIEHS)
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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