In Vitro Degradation of PLLA/nHA Composite Scaffolds

Porous Poly-L-lactide (PLLA) scaffolds and PLLA/nanohydroxyapatite (nHA) composite scaffolds with interconnected pore networks and a porosity of over 90% were fabricated with lyophilization techniques. In this study, the degradation behavior of PLLA and PLLA/nHA composite scaffolds is investigated o...

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Autores: Díaz Tajada, Esperanza, Sandonis Oleaga, Iván, Puerto Lecanda, Igor, Ibáñez Fernández, María del Mar
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/65918
Acceso en línea:http://hdl.handle.net/10810/65918
Access Level:acceso abierto
Palabra clave:scaffolds
PLLA
nHA
degradation
in vitro
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spelling In Vitro Degradation of PLLA/nHA Composite ScaffoldsDíaz Tajada, EsperanzaSandonis Oleaga, IvánPuerto Lecanda, IgorIbáñez Fernández, María del MarscaffoldsPLLAnHAdegradationin vitroPorous Poly-L-lactide (PLLA) scaffolds and PLLA/nanohydroxyapatite (nHA) composite scaffolds with interconnected pore networks and a porosity of over 90% were fabricated with lyophilization techniques. In this study, the degradation behavior of PLLA and PLLA/nHA composite scaffolds is investigated over 8 weeks in phosphate buffer solution at 37 C. Thermal analysis using differential scanning calorimetry (DSC) showed that the percent crystallinity of all the samples increased by approximately 10%, which represents a considerable increase in the glass transition temperature. The melting range enthalpy of the scaffolds did not change to lower temperatures as would be expected. The spectroscopic analysis performed by Fourier transform infrared spectroscopy suggested that nHA particles should not appreciably affect the absorbance pattern when evenly mixed with the PLLA. This is consistent with the analysis of the scaffold microstructure and morphology with scanning electron microscopy, which drew a low content of nHA with no significant effect on solvent crystallization or pore structure. The compressive modulus and the yield strength of the scaffolds were investigated in conjunction with the study of their degradation rates. In comparison with the mechanical properties of the PLLA scaffolds, which remained largely unchanged, those of the PLLA/nHA composite scaffolds decreased as the degradation progressed. POLYM. ENG. SCI., 54:2571–2578, 2014. VC 2013 Society of Plastics EngineersWiley202420242013info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/65918reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://4spepublications.onlinelibrary.wiley.com/doi/full/10.1002/pen.23806info:eu-repo/semantics/openAccess© 2013 Society of Plastics Engineersoai:addi.ehu.eus:10810/659182026-06-18T09:23:17Z
dc.title.none.fl_str_mv In Vitro Degradation of PLLA/nHA Composite Scaffolds
title In Vitro Degradation of PLLA/nHA Composite Scaffolds
spellingShingle In Vitro Degradation of PLLA/nHA Composite Scaffolds
Díaz Tajada, Esperanza
scaffolds
PLLA
nHA
degradation
in vitro
title_short In Vitro Degradation of PLLA/nHA Composite Scaffolds
title_full In Vitro Degradation of PLLA/nHA Composite Scaffolds
title_fullStr In Vitro Degradation of PLLA/nHA Composite Scaffolds
title_full_unstemmed In Vitro Degradation of PLLA/nHA Composite Scaffolds
title_sort In Vitro Degradation of PLLA/nHA Composite Scaffolds
dc.creator.none.fl_str_mv Díaz Tajada, Esperanza
Sandonis Oleaga, Iván
Puerto Lecanda, Igor
Ibáñez Fernández, María del Mar
author Díaz Tajada, Esperanza
author_facet Díaz Tajada, Esperanza
Sandonis Oleaga, Iván
Puerto Lecanda, Igor
Ibáñez Fernández, María del Mar
author_role author
author2 Sandonis Oleaga, Iván
Puerto Lecanda, Igor
Ibáñez Fernández, María del Mar
author2_role author
author
author
dc.subject.none.fl_str_mv scaffolds
PLLA
nHA
degradation
in vitro
topic scaffolds
PLLA
nHA
degradation
in vitro
description Porous Poly-L-lactide (PLLA) scaffolds and PLLA/nanohydroxyapatite (nHA) composite scaffolds with interconnected pore networks and a porosity of over 90% were fabricated with lyophilization techniques. In this study, the degradation behavior of PLLA and PLLA/nHA composite scaffolds is investigated over 8 weeks in phosphate buffer solution at 37 C. Thermal analysis using differential scanning calorimetry (DSC) showed that the percent crystallinity of all the samples increased by approximately 10%, which represents a considerable increase in the glass transition temperature. The melting range enthalpy of the scaffolds did not change to lower temperatures as would be expected. The spectroscopic analysis performed by Fourier transform infrared spectroscopy suggested that nHA particles should not appreciably affect the absorbance pattern when evenly mixed with the PLLA. This is consistent with the analysis of the scaffold microstructure and morphology with scanning electron microscopy, which drew a low content of nHA with no significant effect on solvent crystallization or pore structure. The compressive modulus and the yield strength of the scaffolds were investigated in conjunction with the study of their degradation rates. In comparison with the mechanical properties of the PLLA scaffolds, which remained largely unchanged, those of the PLLA/nHA composite scaffolds decreased as the degradation progressed. POLYM. ENG. SCI., 54:2571–2578, 2014. VC 2013 Society of Plastics Engineers
publishDate 2013
dc.date.none.fl_str_mv 2013
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/65918
url http://hdl.handle.net/10810/65918
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://4spepublications.onlinelibrary.wiley.com/doi/full/10.1002/pen.23806
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
© 2013 Society of Plastics Engineers
eu_rights_str_mv openAccess
rights_invalid_str_mv © 2013 Society of Plastics Engineers
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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