Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease

Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting millions of patients worldwide. Previous studies have demonstrated alterations in the lipid composition of lipid extracts from plasma and brain samples of AD patients. However, there is no consensus regarding the qual...

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Authors: González de San Román, Estíbaliz, Manuel, Iván, Giralt, M. Teresa, Ferrer, Isidro (Ferrer Abizanda), Rodríguez Puertas, Rafael
Format: article
Status:Versión aceptada para publicación
Publication Date:2017
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/140120
Online Access:https://hdl.handle.net/2445/140120
Access Level:Open access
Keyword:Malaltia d'Alzheimer
Metabolisme
Lòbul frontal
Química
Lípids
Desorció-ionització amb làser assistit per matriu
Alzheimer's disease
Metabolism
Frontal lobe
Chemistry
Lipids
Matrix-assisted laser desorption-ionization
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oai_identifier_str oai:recercat.cat:2445/140120
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spelling Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's diseaseGonzález de San Román, EstíbalizManuel, IvánGiralt, M. TeresaFerrer, Isidro (Ferrer Abizanda)Rodríguez Puertas, RafaelMalaltia d'AlzheimerMetabolismeLòbul frontalQuímicaLípidsDesorció-ionització amb làser assistit per matriuAlzheimer's diseaseMetabolismFrontal lobeChemistryLipidsMatrix-assisted laser desorption-ionizationAlzheimer's disease (AD) is a progressive neurodegenerative disease affecting millions of patients worldwide. Previous studies have demonstrated alterations in the lipid composition of lipid extracts from plasma and brain samples of AD patients. However, there is no consensus regarding the qualitative and quantitative changes of lipids in brains from AD patients. In addition, the recent developments in imaging mass spectrometry methods are leading to a new stage in the in situ analysis of lipid species in brain tissue slices from human postmortem samples. The present study uses the matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS), permitting the direct anatomical analysis of lipids in postmortem brain sections from AD patients, which are compared with the intensity of the lipid signal in samples from matched subjects with no neurological diseases. The frontal cortex samples from AD patients were classified in three groups based on Braak's histochemical criteria, ranging from non-cognitively impaired patients to those severely affected. The main results indicate a depletion of different sulfatide lipid species from the earliest stages of the disease in both white and gray matter areas of the frontal cortex. Therefore, the decrease in sulfatides in cortical areas could be considered as a marker of the disease, but may also indicate neurochemical modifications related to the pathogenesis of the disease.Elsevier B.V.2019201920172019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion11 p.application/pdfhttps://hdl.handle.net/2445/140120Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.bbamem.2017.05.009Biochimica et Biophysica Acta, 2017, vol. 1859, num. (9 Pt B), p. 1604-1614https://doi.org/10.1016/j.bbamem.2017.05.009cc-by-nc-nd (c) Elsevier B.V., 2017http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1401202026-05-29T05:05:01Z
dc.title.none.fl_str_mv Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease
title Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease
spellingShingle Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease
González de San Román, Estíbaliz
Malaltia d'Alzheimer
Metabolisme
Lòbul frontal
Química
Lípids
Desorció-ionització amb làser assistit per matriu
Alzheimer's disease
Metabolism
Frontal lobe
Chemistry
Lipids
Matrix-assisted laser desorption-ionization
title_short Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease
title_full Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease
title_fullStr Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease
title_full_unstemmed Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease
title_sort Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease
dc.creator.none.fl_str_mv González de San Román, Estíbaliz
Manuel, Iván
Giralt, M. Teresa
Ferrer, Isidro (Ferrer Abizanda)
Rodríguez Puertas, Rafael
author González de San Román, Estíbaliz
author_facet González de San Román, Estíbaliz
Manuel, Iván
Giralt, M. Teresa
Ferrer, Isidro (Ferrer Abizanda)
Rodríguez Puertas, Rafael
author_role author
author2 Manuel, Iván
Giralt, M. Teresa
Ferrer, Isidro (Ferrer Abizanda)
Rodríguez Puertas, Rafael
author2_role author
author
author
author
dc.subject.none.fl_str_mv Malaltia d'Alzheimer
Metabolisme
Lòbul frontal
Química
Lípids
Desorció-ionització amb làser assistit per matriu
Alzheimer's disease
Metabolism
Frontal lobe
Chemistry
Lipids
Matrix-assisted laser desorption-ionization
topic Malaltia d'Alzheimer
Metabolisme
Lòbul frontal
Química
Lípids
Desorció-ionització amb làser assistit per matriu
Alzheimer's disease
Metabolism
Frontal lobe
Chemistry
Lipids
Matrix-assisted laser desorption-ionization
description Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting millions of patients worldwide. Previous studies have demonstrated alterations in the lipid composition of lipid extracts from plasma and brain samples of AD patients. However, there is no consensus regarding the qualitative and quantitative changes of lipids in brains from AD patients. In addition, the recent developments in imaging mass spectrometry methods are leading to a new stage in the in situ analysis of lipid species in brain tissue slices from human postmortem samples. The present study uses the matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS), permitting the direct anatomical analysis of lipids in postmortem brain sections from AD patients, which are compared with the intensity of the lipid signal in samples from matched subjects with no neurological diseases. The frontal cortex samples from AD patients were classified in three groups based on Braak's histochemical criteria, ranging from non-cognitively impaired patients to those severely affected. The main results indicate a depletion of different sulfatide lipid species from the earliest stages of the disease in both white and gray matter areas of the frontal cortex. Therefore, the decrease in sulfatides in cortical areas could be considered as a marker of the disease, but may also indicate neurochemical modifications related to the pathogenesis of the disease.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/140120
url https://hdl.handle.net/2445/140120
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.bbamem.2017.05.009
Biochimica et Biophysica Acta, 2017, vol. 1859, num. (9 Pt B), p. 1604-1614
https://doi.org/10.1016/j.bbamem.2017.05.009
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier B.V., 2017
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier B.V., 2017
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408596786151424
score 15,198674

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