The microproteome of cancer: from invisibility to relevance

Càncer; Micropèptid; Supressors de tumors

Bibliographic Details
Authors: Merino Valverde, Iñaki, Greco, Emanuela, Abad Mendez, Maria
Format: article
Status:Published version
Publication Date:2020
Country:España
Institution:Departament de Salut de la Generalitat de Catalunya (DS)
Repository:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/6530
Online Access:https://hdl.handle.net/11351/6530
Access Level:Open access
Keyword:Càncer
Proteòmica
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins
Other subheadings::Other subheadings::/physiology
DISEASES::Neoplasms
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de neoplasias
Otros calificadores::Otros calificadores::/fisiología
ENFERMEDADES::neoplasias
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network_acronym_str ES
network_name_str España
repository_id_str
spelling The microproteome of cancer: from invisibility to relevanceMerino Valverde, IñakiGreco, EmanuelaAbad Mendez, MariaCàncerProteòmicaCHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm ProteinsOther subheadings::Other subheadings::/physiologyDISEASES::NeoplasmsCOMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de neoplasiasOtros calificadores::Otros calificadores::/fisiologíaENFERMEDADES::neoplasiasCàncer; Micropèptid; Supressors de tumorsCáncer; Micropéptido; Supresores de tumoresCancer; Micropeptide; Tumor suppressorsRecent findings have revealed that many genomic regions previously annotated as non-protein coding actually contain small open reading frames, smaller that 300 bp, that are transcribed and translated into evolutionary conserved microproteins. To date, only a small subset of them have been functionally characterized, but they play key functions in fundamental processes such as DNA repair, RNA processing and metabolism regulation. This emergent field seems to hide a new category of molecular regulators with clinical potential. In this review, we focus on its relevance for cancer. Following Hanahan and Weinberg's classification of the hallmarks of cancer, we provide an overview of those microproteins known to be implicated in cancer or those that, based on their function, are likely to play a role in cancer. The resulting picture is that while we are at the very early times of this field, it holds the promise to provide crucial information to understand cancer biology.ElsevierInstitut Català de la Salut[Merino-Valverde I, Greco E, Abad M] Vall d'Hebron Institute of Oncology (VHIO), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202120212020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/6530Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésExperimental Cell Research;392https://doi.org/10.1016/j.yexcr.2020.111997Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/65302026-06-12T09:38:37Z
dc.title.none.fl_str_mv The microproteome of cancer: from invisibility to relevance
title The microproteome of cancer: from invisibility to relevance
spellingShingle The microproteome of cancer: from invisibility to relevance
Merino Valverde, Iñaki
Càncer
Proteòmica
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins
Other subheadings::Other subheadings::/physiology
DISEASES::Neoplasms
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de neoplasias
Otros calificadores::Otros calificadores::/fisiología
ENFERMEDADES::neoplasias
title_short The microproteome of cancer: from invisibility to relevance
title_full The microproteome of cancer: from invisibility to relevance
title_fullStr The microproteome of cancer: from invisibility to relevance
title_full_unstemmed The microproteome of cancer: from invisibility to relevance
title_sort The microproteome of cancer: from invisibility to relevance
dc.creator.none.fl_str_mv Merino Valverde, Iñaki
Greco, Emanuela
Abad Mendez, Maria
author Merino Valverde, Iñaki
author_facet Merino Valverde, Iñaki
Greco, Emanuela
Abad Mendez, Maria
author_role author
author2 Greco, Emanuela
Abad Mendez, Maria
author2_role author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Merino-Valverde I, Greco E, Abad M] Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Càncer
Proteòmica
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins
Other subheadings::Other subheadings::/physiology
DISEASES::Neoplasms
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de neoplasias
Otros calificadores::Otros calificadores::/fisiología
ENFERMEDADES::neoplasias
topic Càncer
Proteòmica
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins
Other subheadings::Other subheadings::/physiology
DISEASES::Neoplasms
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de neoplasias
Otros calificadores::Otros calificadores::/fisiología
ENFERMEDADES::neoplasias
description Càncer; Micropèptid; Supressors de tumors
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/6530
url https://hdl.handle.net/11351/6530
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Experimental Cell Research;392
https://doi.org/10.1016/j.yexcr.2020.111997
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408595311853568
score 15,811543

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