Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist

Reproducció del document publicat a:https://doi.org/10.1002/advs.202005027

Detalles Bibliográficos
Autores: Barbero Castillo, Almudena, Riefolo, Fabio, Matera, Carlo, Caldas Martínez, Sara, Mateos Aparicio, Pedro, Weinert, Julia F., Garrido Charles, Aida, Claro Izaguirre, Enrique, Sánchez-Vives, María Victoria, Gorostiza Langa, Pablo Ignacio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/178112
Acceso en línea:https://hdl.handle.net/2445/178112
Access Level:acceso abierto
Palabra clave:Neurociències
Neurologia
Neurosciences
Neurology
id ES_58ec36054e30cb0b22016d96a8a60967
oai_identifier_str oai:recercat.cat:2445/178112
network_acronym_str ES
network_name_str España
repository_id_str
spelling Control of Brain State Transitions with a Photoswitchable Muscarinic AgonistBarbero Castillo, AlmudenaRiefolo, FabioMatera, CarloCaldas Martínez, SaraMateos Aparicio, PedroWeinert, Julia F.Garrido Charles, AidaClaro Izaguirre, EnriqueSánchez-Vives, María VictoriaGorostiza Langa, Pablo IgnacioNeurociènciesNeurologiaNeurosciencesNeurologyReproducció del document publicat a:https://doi.org/10.1002/advs.202005027The ability to control neural activity is essential for research not only in basic neuroscience, as spatiotemporal control of activity is a fundamental experimental tool, but also in clinical neurology for therapeutic brain interventions. Transcranial-magnetic, ultrasound, and alternating/direct current (AC/DC) stimulation are some available means of spatiotemporal controlled neuromodulation. There is also light-mediated control, such as optogenetics, which has revolutionized neuroscience research, yet its clinical translation is hampered by the need for gene manipulation. As a drug-based light-mediated control, the effect of a photoswitchable muscarinic agonist (Phthalimide-Azo-Iper (PAI)) on a brain network is evaluated in this study. First, the conditions to manipulate M2 muscarinic receptors with light in the experimental setup are determined. Next, physiological synchronous emergent cortical activity consisting of slow oscillations—as in slow wave sleep—is transformed into a higher frequency pattern in the cerebral cortex, both in vitro and in vivo, as a consequence of PAI activation with light. These results open the way to study cholinergic neuromodulation and to control spatiotemporal patterns of activity in different brain states, their transitions, and their links to cognition and behavior. The approach can be applied to different organisms and does not require genetic manipulation, which would make it translational to humans.Wiley-VCH202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/178112Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAdvanced Science, 2021https://doi.org/10.1002/advs.202005027info:eu-repo/grantAgreement/EC/H2020/945539cc by (c) Barbero Castillo et al., 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1781122026-05-29T05:05:01Z
dc.title.none.fl_str_mv Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist
title Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist
spellingShingle Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist
Barbero Castillo, Almudena
Neurociències
Neurologia
Neurosciences
Neurology
title_short Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist
title_full Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist
title_fullStr Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist
title_full_unstemmed Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist
title_sort Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist
dc.creator.none.fl_str_mv Barbero Castillo, Almudena
Riefolo, Fabio
Matera, Carlo
Caldas Martínez, Sara
Mateos Aparicio, Pedro
Weinert, Julia F.
Garrido Charles, Aida
Claro Izaguirre, Enrique
Sánchez-Vives, María Victoria
Gorostiza Langa, Pablo Ignacio
author Barbero Castillo, Almudena
author_facet Barbero Castillo, Almudena
Riefolo, Fabio
Matera, Carlo
Caldas Martínez, Sara
Mateos Aparicio, Pedro
Weinert, Julia F.
Garrido Charles, Aida
Claro Izaguirre, Enrique
Sánchez-Vives, María Victoria
Gorostiza Langa, Pablo Ignacio
author_role author
author2 Riefolo, Fabio
Matera, Carlo
Caldas Martínez, Sara
Mateos Aparicio, Pedro
Weinert, Julia F.
Garrido Charles, Aida
Claro Izaguirre, Enrique
Sánchez-Vives, María Victoria
Gorostiza Langa, Pablo Ignacio
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neurociències
Neurologia
Neurosciences
Neurology
topic Neurociències
Neurologia
Neurosciences
Neurology
description Reproducció del document publicat a:https://doi.org/10.1002/advs.202005027
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/178112
url https://hdl.handle.net/2445/178112
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Advanced Science, 2021
https://doi.org/10.1002/advs.202005027
info:eu-repo/grantAgreement/EC/H2020/945539
dc.rights.none.fl_str_mv cc by (c) Barbero Castillo et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Barbero Castillo et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408577834188800
score 15,811543

Similares en LA Referencia