Chitinases and chitinase-like proteins as biomarkers in neurologic disorders

Esclerosi múltiple; Malaltia d'Alzheimer; Esclerosi lateral amiotròfica

Bibliographic Details
Authors: Pinteac, Rucsanda, Montalban Gairín, Xavier, Comabella Lopez, Manuel
Format: article
Status:Published version
Publication Date:2020
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/7158
Online Access:https://hdl.handle.net/11351/7158
http://hdl.handle.net/11351/7158
Access Level:Open access
Keyword:Sistema nerviós - Malalties - Tractament
Enzims - Metabolisme
DISEASES::Nervous System Diseases
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/enzymology
CHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Hydrolases::Glycoside Hydrolases::Chitinases
Other subheadings::Other subheadings::Other subheadings::/metabolism
ENFERMEDADES::enfermedades del sistema nervioso
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/enzimología
COMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::hidrolasas::glicósido hidrolasas::quitinasas
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Chitinases and chitinase-like proteins as biomarkers in neurologic disordersPinteac, RucsandaMontalban Gairín, XavierComabella Lopez, ManuelSistema nerviós - Malalties - TractamentEnzims - MetabolismeDISEASES::Nervous System DiseasesOther subheadings::Other subheadings::Other subheadings::Other subheadings::/enzymologyCHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Hydrolases::Glycoside Hydrolases::ChitinasesOther subheadings::Other subheadings::Other subheadings::/metabolismENFERMEDADES::enfermedades del sistema nerviosoOtros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/enzimologíaCOMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::hidrolasas::glicósido hidrolasas::quitinasasOtros calificadores::Otros calificadores::Otros calificadores::/metabolismoEsclerosi múltiple; Malaltia d'Alzheimer; Esclerosi lateral amiotròficaEsclerosis múltiple; Enfermedad de alzheimer; Esclerosis lateral amiotróficaMultiple sclerosis; Alzheimer's disease; Amyotrophic lateral sclerosisChitinases are hydrolytic enzymes widely distributed in nature. Despite their physiologic and pathophysiologic roles are not well understood, chitinases are emerging as biomarkers in a broad range of neurologic disorders, where in many cases, protein levels measured in the CSF have been shown to correlate with disease activity and progression. In this review, we will summarize the structural features of human chitinases and chitinase-like proteins and their potential physiologic and pathologic functions in the CNS. We will also review existing evidence for the role of chitinases and chitinase-like proteins as diagnostic and prognostic biomarkers in inflammatory, neurodegenerative diseases, and psychiatric disorders. Finally, we will comment on future perspectives of chitinase studies in neurologic conditions.No targeted funding reported.Lippincott Williams & WilkinsInstitut Català de la Salut[Pinteac R, Comabella M] Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Montalban X] Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus2022202220202021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7158http://hdl.handle.net/11351/7158Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésNeurology-Neuroimmunology & Neuroinflammation;8(1)https://doi.org/10.1212/NXI.0000000000000921Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/71582026-05-29T05:05:01Z
dc.title.none.fl_str_mv Chitinases and chitinase-like proteins as biomarkers in neurologic disorders
title Chitinases and chitinase-like proteins as biomarkers in neurologic disorders
spellingShingle Chitinases and chitinase-like proteins as biomarkers in neurologic disorders
Pinteac, Rucsanda
Sistema nerviós - Malalties - Tractament
Enzims - Metabolisme
DISEASES::Nervous System Diseases
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/enzymology
CHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Hydrolases::Glycoside Hydrolases::Chitinases
Other subheadings::Other subheadings::Other subheadings::/metabolism
ENFERMEDADES::enfermedades del sistema nervioso
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/enzimología
COMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::hidrolasas::glicósido hidrolasas::quitinasas
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
title_short Chitinases and chitinase-like proteins as biomarkers in neurologic disorders
title_full Chitinases and chitinase-like proteins as biomarkers in neurologic disorders
title_fullStr Chitinases and chitinase-like proteins as biomarkers in neurologic disorders
title_full_unstemmed Chitinases and chitinase-like proteins as biomarkers in neurologic disorders
title_sort Chitinases and chitinase-like proteins as biomarkers in neurologic disorders
dc.creator.none.fl_str_mv Pinteac, Rucsanda
Montalban Gairín, Xavier
Comabella Lopez, Manuel
author Pinteac, Rucsanda
author_facet Pinteac, Rucsanda
Montalban Gairín, Xavier
Comabella Lopez, Manuel
author_role author
author2 Montalban Gairín, Xavier
Comabella Lopez, Manuel
author2_role author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Pinteac R, Comabella M] Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Montalban X] Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Sistema nerviós - Malalties - Tractament
Enzims - Metabolisme
DISEASES::Nervous System Diseases
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/enzymology
CHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Hydrolases::Glycoside Hydrolases::Chitinases
Other subheadings::Other subheadings::Other subheadings::/metabolism
ENFERMEDADES::enfermedades del sistema nervioso
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/enzimología
COMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::hidrolasas::glicósido hidrolasas::quitinasas
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
topic Sistema nerviós - Malalties - Tractament
Enzims - Metabolisme
DISEASES::Nervous System Diseases
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/enzymology
CHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Hydrolases::Glycoside Hydrolases::Chitinases
Other subheadings::Other subheadings::Other subheadings::/metabolism
ENFERMEDADES::enfermedades del sistema nervioso
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/enzimología
COMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::hidrolasas::glicósido hidrolasas::quitinasas
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
description Esclerosi múltiple; Malaltia d'Alzheimer; Esclerosi lateral amiotròfica
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7158
http://hdl.handle.net/11351/7158
url https://hdl.handle.net/11351/7158
http://hdl.handle.net/11351/7158
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Neurology-Neuroimmunology & Neuroinflammation;8(1)
https://doi.org/10.1212/NXI.0000000000000921
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408575119425536
score 15.811543

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