Body mass index and disease activity in chronic inflammatory rheumatic diseases: Results of the cardiovascular in rheumatology (CARMA) project
Objective: Since obesity has been associated with a higher inflammatory burden and worse response to therapy in patients with chronic inflammatory rheumatic diseases (CIRD), we aimed to confirm the potential association between body mass index (BMI) and disease activity in a large series of patients...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/698020 |
| Acceso en línea: | http://hdl.handle.net/10486/698020 https://dx.doi.org/10.3390/jcm10030382 |
| Access Level: | acceso abierto |
| Palabra clave: | Ankylosing spondylitis Body mass index Obesity Psoriatic arthritis and disease activity Rheumatoid arthritis Medicina |
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Body mass index and disease activity in chronic inflammatory rheumatic diseases: Results of the cardiovascular in rheumatology (CARMA) projectValero-Jaimes, Jesús A.López-González, RuthMartín-Martínez, María A.García-Gómez, CarmenSánchez-Alonso, FernandoSánchez-Costa, Jesús T.González-Juanatey, CarlosRevuelta-Evrad, EvaDíaz-Torné, CésarFernández-Espartero, CruzPérez-García, CarolinaTorrente-Segarra, VicençSánchez-Nievas, GinésPérez-Sandoval, TrinidadFont-Ugalde, PilarGarcía-Vivar, María L.Aurrecoechea, ElenaMaiz Alonso, OlgaValls-García, RamónMiranda-Filloy, José A.Llorca, JavierCastañeda Sanz, SantosGonzalez-Gay, Miguel A.CARMA Study GroupAnkylosing spondylitisBody mass indexObesityPsoriatic arthritis and disease activityRheumatoid arthritisMedicinaObjective: Since obesity has been associated with a higher inflammatory burden and worse response to therapy in patients with chronic inflammatory rheumatic diseases (CIRD), we aimed to confirm the potential association between body mass index (BMI) and disease activity in a large series of patients with CIRDs included in the Spanish CARdiovascular in rheuMAtology (CARMA) registry. Methods: Baseline data analysis of patients included from the CARMA project, a 10‐year prospective study of patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) attending outpatient rheumatology clinics from 67 Spanish hospitals. Obesity was defined when BMI (kg/m2) was >30 according to the WHO criteria. Scores used to evaluate disease activity were Disease Activity Score of 28 joints (DAS28) in RA, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in AS, and modified DAS for PsA. Results: Data from 2234 patients (775 RA, 738 AS, and 721 PsA) were assessed. The mean ± SD BMI at the baseline visit were: 26.9 ± 4.8 in RA, 27.4 ± 4.4 in AS, and 28.2 ± 4.7 in PsA. A positive association between BMI and disease activity in patients with RA (β = 0.029; 95%CI (0.01‐ 0.05); p = 0.007) and PsA (β = 0.036; 95%CI (0.015–0.058); p = 0.001) but not in those with AS (β = 0.001; 95%CI (−0.03–0.03); p = 0.926) was found. Disease activity was associated with female sex and rheumatoid factor in RA and with Psoriasis Area Severity Index and enthesitis in PsA. Conclusions: BMI is associated with disease activity in RA and PsA, but not in AS. Given that obesity is a potentially modifiable factor, adequate control of body weight can improve the outcome of patients with CIRD and, therefore, weight control should be included in the management strategy of these patients.This project has been supported by an unrestricted grant from Abbvie, Spain. Nonetheless, the design, analysis, interpretation of results, and preparation of the manuscript have been done independently of Abbvie. Professor González-Gay’s studies have been supported by grants from “Fondo de Investigaciones Sanitarias” PI06/0024, PS09/00748, PI12/00060, PI15/00525, PI18/00043, and RD12/0009/0013 and RD16/0012 (RIER) from “Instituto de Salud Carlos III” (ISCIII) (Spain), co-funded by FEDER fundsMDPI, Basel, SwitzerlandDepartamento de MedicinaFacultad de MedicinaInstituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP)20212021-01-20research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/698020https://dx.doi.org/10.3390/jcm10030382reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6980202026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
Body mass index and disease activity in chronic inflammatory rheumatic diseases: Results of the cardiovascular in rheumatology (CARMA) project |
| title |
Body mass index and disease activity in chronic inflammatory rheumatic diseases: Results of the cardiovascular in rheumatology (CARMA) project |
| spellingShingle |
Body mass index and disease activity in chronic inflammatory rheumatic diseases: Results of the cardiovascular in rheumatology (CARMA) project Valero-Jaimes, Jesús A. Ankylosing spondylitis Body mass index Obesity Psoriatic arthritis and disease activity Rheumatoid arthritis Medicina |
| title_short |
Body mass index and disease activity in chronic inflammatory rheumatic diseases: Results of the cardiovascular in rheumatology (CARMA) project |
| title_full |
Body mass index and disease activity in chronic inflammatory rheumatic diseases: Results of the cardiovascular in rheumatology (CARMA) project |
| title_fullStr |
Body mass index and disease activity in chronic inflammatory rheumatic diseases: Results of the cardiovascular in rheumatology (CARMA) project |
| title_full_unstemmed |
Body mass index and disease activity in chronic inflammatory rheumatic diseases: Results of the cardiovascular in rheumatology (CARMA) project |
| title_sort |
Body mass index and disease activity in chronic inflammatory rheumatic diseases: Results of the cardiovascular in rheumatology (CARMA) project |
| dc.creator.none.fl_str_mv |
Valero-Jaimes, Jesús A. López-González, Ruth Martín-Martínez, María A. García-Gómez, Carmen Sánchez-Alonso, Fernando Sánchez-Costa, Jesús T. González-Juanatey, Carlos Revuelta-Evrad, Eva Díaz-Torné, César Fernández-Espartero, Cruz Pérez-García, Carolina Torrente-Segarra, Vicenç Sánchez-Nievas, Ginés Pérez-Sandoval, Trinidad Font-Ugalde, Pilar García-Vivar, María L. Aurrecoechea, Elena Maiz Alonso, Olga Valls-García, Ramón Miranda-Filloy, José A. Llorca, Javier Castañeda Sanz, Santos Gonzalez-Gay, Miguel A. CARMA Study Group |
| author |
Valero-Jaimes, Jesús A. |
| author_facet |
Valero-Jaimes, Jesús A. López-González, Ruth Martín-Martínez, María A. García-Gómez, Carmen Sánchez-Alonso, Fernando Sánchez-Costa, Jesús T. González-Juanatey, Carlos Revuelta-Evrad, Eva Díaz-Torné, César Fernández-Espartero, Cruz Pérez-García, Carolina Torrente-Segarra, Vicenç Sánchez-Nievas, Ginés Pérez-Sandoval, Trinidad Font-Ugalde, Pilar García-Vivar, María L. Aurrecoechea, Elena Maiz Alonso, Olga Valls-García, Ramón Miranda-Filloy, José A. Llorca, Javier Castañeda Sanz, Santos Gonzalez-Gay, Miguel A. CARMA Study Group |
| author_role |
author |
| author2 |
López-González, Ruth Martín-Martínez, María A. García-Gómez, Carmen Sánchez-Alonso, Fernando Sánchez-Costa, Jesús T. González-Juanatey, Carlos Revuelta-Evrad, Eva Díaz-Torné, César Fernández-Espartero, Cruz Pérez-García, Carolina Torrente-Segarra, Vicenç Sánchez-Nievas, Ginés Pérez-Sandoval, Trinidad Font-Ugalde, Pilar García-Vivar, María L. Aurrecoechea, Elena Maiz Alonso, Olga Valls-García, Ramón Miranda-Filloy, José A. Llorca, Javier Castañeda Sanz, Santos Gonzalez-Gay, Miguel A. CARMA Study Group |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Medicina Facultad de Medicina Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP) |
| dc.subject.none.fl_str_mv |
Ankylosing spondylitis Body mass index Obesity Psoriatic arthritis and disease activity Rheumatoid arthritis Medicina |
| topic |
Ankylosing spondylitis Body mass index Obesity Psoriatic arthritis and disease activity Rheumatoid arthritis Medicina |
| description |
Objective: Since obesity has been associated with a higher inflammatory burden and worse response to therapy in patients with chronic inflammatory rheumatic diseases (CIRD), we aimed to confirm the potential association between body mass index (BMI) and disease activity in a large series of patients with CIRDs included in the Spanish CARdiovascular in rheuMAtology (CARMA) registry. Methods: Baseline data analysis of patients included from the CARMA project, a 10‐year prospective study of patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) attending outpatient rheumatology clinics from 67 Spanish hospitals. Obesity was defined when BMI (kg/m2) was >30 according to the WHO criteria. Scores used to evaluate disease activity were Disease Activity Score of 28 joints (DAS28) in RA, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in AS, and modified DAS for PsA. Results: Data from 2234 patients (775 RA, 738 AS, and 721 PsA) were assessed. The mean ± SD BMI at the baseline visit were: 26.9 ± 4.8 in RA, 27.4 ± 4.4 in AS, and 28.2 ± 4.7 in PsA. A positive association between BMI and disease activity in patients with RA (β = 0.029; 95%CI (0.01‐ 0.05); p = 0.007) and PsA (β = 0.036; 95%CI (0.015–0.058); p = 0.001) but not in those with AS (β = 0.001; 95%CI (−0.03–0.03); p = 0.926) was found. Disease activity was associated with female sex and rheumatoid factor in RA and with Psoriasis Area Severity Index and enthesitis in PsA. Conclusions: BMI is associated with disease activity in RA and PsA, but not in AS. Given that obesity is a potentially modifiable factor, adequate control of body weight can improve the outcome of patients with CIRD and, therefore, weight control should be included in the management strategy of these patients. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-01-20 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10486/698020 https://dx.doi.org/10.3390/jcm10030382 |
| url |
http://hdl.handle.net/10486/698020 https://dx.doi.org/10.3390/jcm10030382 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI, Basel, Switzerland |
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MDPI, Basel, Switzerland |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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1869408574171512832 |
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15.300719 |