Serum Homocysteine Levels in Patients with Retinal Vein Occlusion in a Spanish Population
Purpose Our aim was a) to compare serum Hcy levels in patients with RVO and population-based controls, and b) to evaluate whether hyperhomocysteinemia is a risk factor for RVO. Patients and methods Prospective case-control study of all patients diagnosed with RVO at a tertiary-care hospital, and age...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universidad de Cantabria (UC) |
| Repositorio: | UCrea Repositorio Abierto de la Universidad de Cantabria |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unican.es:10902/24839 |
| Acceso en línea: | http://hdl.handle.net/10902/24839 |
| Access Level: | acceso abierto |
| Palabra clave: | Retinal vein occlusion Homocysteine Hyperhomocysteinemia Risk factor |
| Sumario: | Purpose Our aim was a) to compare serum Hcy levels in patients with RVO and population-based controls, and b) to evaluate whether hyperhomocysteinemia is a risk factor for RVO. Patients and methods Prospective case-control study of all patients diagnosed with RVO at a tertiary-care hospital, and age-and sex-matched controls taking part in a population-based prospective cohort in the same geographic area. Differences in serum Hcy between both groups were analyzed by a general linear model adjusted for age, body mass index (BMI), glomerular filtration rate (GFR), hypertension, dyslipidemia, diabetes, tobacco use and alcohol intake. Besides, we tested the relationship between hyperhomocysteinemia (> 15 µmol/L) and RVO, by a stepwise logistic regression analysis. Results RVO patients (n = 85) had a higher prevalence of hypertension (p = 0.002), diabetes (p = 0.008), and dyslipidemia (p = 0.04) than controls (n = 82). Adjusted median Hcy levels were higher in RVO patients (p < 0.0001). Adjusted OR for hyperhomocysteinemia were 4.4 (95% CI, 2.0-9.3; p < 0.0001) in the overall sample, and 2.6 (95% CI, 1.04-6.6; p = 0.04) and 6.1 (95% CI, 1.7-21.6; p = 0.005) for men and women, respectively. Conclusion Patients with RVO have higher serum Hcy levels than age- and sex-matched population-based controls. Hyperhomocysteinemia seems to be a risk factor for RVO, independent of age, BMI, GFR and classical vascular risk factors. |
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