Circulating microRNAs and their role in multiple myeloma

Federico, C. (Cinzia)|||/items/aeeca1ae-b655-4154-be0e-47656cbe1d87; Sacco, A. (Antonio)|||/items/878c6ecd-c1ba-492e-8676-41faceb8fa91; Belotti, A. (Angelo)|||/items/e3cd3c96-ef15-496f-a325-c47f461850e0; Ribolla, R. (Rossella)|||/items/f0743733-d85c-4b14-9e2f-0591290c563e; Cancelli, V. (Valeria)|||/items/38e9fdb3-6d38-40fe-8b2a-7caafc95864e; Giacomini, A. (Arianna)|||/items/9dc5e35a-4a80-4b45-800a-f68dd6e44591; Ronca, R. (Roberto)|||/items/67c5e0cd-5fc0-4a83-93b5-e95b3b559415; Chiarini, M. (Marco)|||/items/0938193d-fabf-48b3-a5a2-81e7a547869e; Imberti, L. (Luisa)|||/items/ce877e35-3265-49c7-b7ed-aeec1ec81119; Marini, M. (Mirella)|||/items/5cf09148-1faa-4589-a8df-58aea5658800; Rossi, G. (Giuseppe)|||/items/43494569-46e0-4c6f-9541-ad5da3d5c923; Presta, M. (Marco)|||/items/bf4f1122-25dd-442d-bee5-aaa6dcb37b0b; Paiva, B. (Bruno)|||/items/b2c3efc5-27e1-4425-b452-efba1522c1d5; Roccaro, A.M. (Aldo M.)|||/items/a520dfdf-e922-49ed-b8f8-dc4cc5bf51f1

Circulating microRNAs and their role in multiple myeloma

Multiple myeloma (MM) is a plasma cell dyscrasia characterized by bone marrow infiltration of clonal plasma cells. The recent literature has clearly demonstrated clonal heterogeneity in terms of both the genomic and transcriptomic signature of the tumor. Of note, novel studies have also highlighted...

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Detalles Bibliográficos
Autores:	Federico, C. (Cinzia)\|\|\|/items/aeeca1ae-b655-4154-be0e-47656cbe1d87, Sacco, A. (Antonio)\|\|\|/items/878c6ecd-c1ba-492e-8676-41faceb8fa91, Belotti, A. (Angelo)\|\|\|/items/e3cd3c96-ef15-496f-a325-c47f461850e0, Ribolla, R. (Rossella)\|\|\|/items/f0743733-d85c-4b14-9e2f-0591290c563e, Cancelli, V. (Valeria)\|\|\|/items/38e9fdb3-6d38-40fe-8b2a-7caafc95864e, Giacomini, A. (Arianna)\|\|\|/items/9dc5e35a-4a80-4b45-800a-f68dd6e44591, Ronca, R. (Roberto)\|\|\|/items/67c5e0cd-5fc0-4a83-93b5-e95b3b559415, Chiarini, M. (Marco)\|\|\|/items/0938193d-fabf-48b3-a5a2-81e7a547869e, Imberti, L. (Luisa)\|\|\|/items/ce877e35-3265-49c7-b7ed-aeec1ec81119, Marini, M. (Mirella)\|\|\|/items/5cf09148-1faa-4589-a8df-58aea5658800, Rossi, G. (Giuseppe)\|\|\|/items/43494569-46e0-4c6f-9541-ad5da3d5c923, Presta, M. (Marco)\|\|\|/items/bf4f1122-25dd-442d-bee5-aaa6dcb37b0b, Paiva, B. (Bruno)\|\|\|/items/b2c3efc5-27e1-4425-b452-efba1522c1d5, Roccaro, A.M. (Aldo M.)\|\|\|/items/a520dfdf-e922-49ed-b8f8-dc4cc5bf51f1
Tipo de recurso:	artículo
Fecha de publicación:	2019
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/62297
Acceso en línea:	https://hdl.handle.net/10171/62297
Access Level:	acceso abierto
Palabra clave:	Multiple myeloma Plasma Cell dyscrasia miRNAs Circulating miRNAs Circulating exosomal-miRNAs

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spelling	Circulating microRNAs and their role in multiple myelomaFederico, C. (Cinzia)\|\|\|/items/aeeca1ae-b655-4154-be0e-47656cbe1d87Sacco, A. (Antonio)\|\|\|/items/878c6ecd-c1ba-492e-8676-41faceb8fa91Belotti, A. (Angelo)\|\|\|/items/e3cd3c96-ef15-496f-a325-c47f461850e0Ribolla, R. (Rossella)\|\|\|/items/f0743733-d85c-4b14-9e2f-0591290c563eCancelli, V. (Valeria)\|\|\|/items/38e9fdb3-6d38-40fe-8b2a-7caafc95864eGiacomini, A. (Arianna)\|\|\|/items/9dc5e35a-4a80-4b45-800a-f68dd6e44591Ronca, R. (Roberto)\|\|\|/items/67c5e0cd-5fc0-4a83-93b5-e95b3b559415Chiarini, M. (Marco)\|\|\|/items/0938193d-fabf-48b3-a5a2-81e7a547869eImberti, L. (Luisa)\|\|\|/items/ce877e35-3265-49c7-b7ed-aeec1ec81119Marini, M. (Mirella)\|\|\|/items/5cf09148-1faa-4589-a8df-58aea5658800Rossi, G. (Giuseppe)\|\|\|/items/43494569-46e0-4c6f-9541-ad5da3d5c923Presta, M. (Marco)\|\|\|/items/bf4f1122-25dd-442d-bee5-aaa6dcb37b0bPaiva, B. (Bruno)\|\|\|/items/b2c3efc5-27e1-4425-b452-efba1522c1d5Roccaro, A.M. (Aldo M.)\|\|\|/items/a520dfdf-e922-49ed-b8f8-dc4cc5bf51f1Multiple myelomaPlasma Cell dyscrasiamiRNAsCirculating miRNAsCirculating exosomal-miRNAsMultiple myeloma (MM) is a plasma cell dyscrasia characterized by bone marrow infiltration of clonal plasma cells. The recent literature has clearly demonstrated clonal heterogeneity in terms of both the genomic and transcriptomic signature of the tumor. Of note, novel studies have also highlighted the importance of the functional cross-talk between the tumor clone and the surrounding bone marrow milieu, as a relevant player of MM pathogenesis. These findings have certainly enhanced our understanding of the underlying mechanisms supporting MM pathogenesis and disease progression. Within the specific field of small non-coding RNA-research, recent studies have provided evidence for considering microRNAs as a crucial regulator of MM biology and, in this context, circulating microRNAs have been shown to potentially contribute to prognostic stratification of MM patients. The present review will summarize the most recent studies within the specific topic of microRNAs and circulating microRNAs in MM.MDPI AGDadun. Depósito Académico Digital Universidad de Navarra20212021-11-0220192019-01-0120192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/62297reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/622972026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Circulating microRNAs and their role in multiple myeloma
title	Circulating microRNAs and their role in multiple myeloma
spellingShingle	Circulating microRNAs and their role in multiple myeloma Federico, C. (Cinzia)\|\|\|/items/aeeca1ae-b655-4154-be0e-47656cbe1d87 Multiple myeloma Plasma Cell dyscrasia miRNAs Circulating miRNAs Circulating exosomal-miRNAs
title_short	Circulating microRNAs and their role in multiple myeloma
title_full	Circulating microRNAs and their role in multiple myeloma
title_fullStr	Circulating microRNAs and their role in multiple myeloma
title_full_unstemmed	Circulating microRNAs and their role in multiple myeloma
title_sort	Circulating microRNAs and their role in multiple myeloma
dc.creator.none.fl_str_mv	Federico, C. (Cinzia)\|\|\|/items/aeeca1ae-b655-4154-be0e-47656cbe1d87 Sacco, A. (Antonio)\|\|\|/items/878c6ecd-c1ba-492e-8676-41faceb8fa91 Belotti, A. (Angelo)\|\|\|/items/e3cd3c96-ef15-496f-a325-c47f461850e0 Ribolla, R. (Rossella)\|\|\|/items/f0743733-d85c-4b14-9e2f-0591290c563e Cancelli, V. (Valeria)\|\|\|/items/38e9fdb3-6d38-40fe-8b2a-7caafc95864e Giacomini, A. (Arianna)\|\|\|/items/9dc5e35a-4a80-4b45-800a-f68dd6e44591 Ronca, R. (Roberto)\|\|\|/items/67c5e0cd-5fc0-4a83-93b5-e95b3b559415 Chiarini, M. (Marco)\|\|\|/items/0938193d-fabf-48b3-a5a2-81e7a547869e Imberti, L. (Luisa)\|\|\|/items/ce877e35-3265-49c7-b7ed-aeec1ec81119 Marini, M. (Mirella)\|\|\|/items/5cf09148-1faa-4589-a8df-58aea5658800 Rossi, G. (Giuseppe)\|\|\|/items/43494569-46e0-4c6f-9541-ad5da3d5c923 Presta, M. (Marco)\|\|\|/items/bf4f1122-25dd-442d-bee5-aaa6dcb37b0b Paiva, B. (Bruno)\|\|\|/items/b2c3efc5-27e1-4425-b452-efba1522c1d5 Roccaro, A.M. (Aldo M.)\|\|\|/items/a520dfdf-e922-49ed-b8f8-dc4cc5bf51f1
author	Federico, C. (Cinzia)\|\|\|/items/aeeca1ae-b655-4154-be0e-47656cbe1d87
author_facet	Federico, C. (Cinzia)\|\|\|/items/aeeca1ae-b655-4154-be0e-47656cbe1d87 Sacco, A. (Antonio)\|\|\|/items/878c6ecd-c1ba-492e-8676-41faceb8fa91 Belotti, A. (Angelo)\|\|\|/items/e3cd3c96-ef15-496f-a325-c47f461850e0 Ribolla, R. (Rossella)\|\|\|/items/f0743733-d85c-4b14-9e2f-0591290c563e Cancelli, V. (Valeria)\|\|\|/items/38e9fdb3-6d38-40fe-8b2a-7caafc95864e Giacomini, A. (Arianna)\|\|\|/items/9dc5e35a-4a80-4b45-800a-f68dd6e44591 Ronca, R. (Roberto)\|\|\|/items/67c5e0cd-5fc0-4a83-93b5-e95b3b559415 Chiarini, M. (Marco)\|\|\|/items/0938193d-fabf-48b3-a5a2-81e7a547869e Imberti, L. (Luisa)\|\|\|/items/ce877e35-3265-49c7-b7ed-aeec1ec81119 Marini, M. (Mirella)\|\|\|/items/5cf09148-1faa-4589-a8df-58aea5658800 Rossi, G. (Giuseppe)\|\|\|/items/43494569-46e0-4c6f-9541-ad5da3d5c923 Presta, M. (Marco)\|\|\|/items/bf4f1122-25dd-442d-bee5-aaa6dcb37b0b Paiva, B. (Bruno)\|\|\|/items/b2c3efc5-27e1-4425-b452-efba1522c1d5 Roccaro, A.M. (Aldo M.)\|\|\|/items/a520dfdf-e922-49ed-b8f8-dc4cc5bf51f1
author_role	author
author2	Sacco, A. (Antonio)\|\|\|/items/878c6ecd-c1ba-492e-8676-41faceb8fa91 Belotti, A. (Angelo)\|\|\|/items/e3cd3c96-ef15-496f-a325-c47f461850e0 Ribolla, R. (Rossella)\|\|\|/items/f0743733-d85c-4b14-9e2f-0591290c563e Cancelli, V. (Valeria)\|\|\|/items/38e9fdb3-6d38-40fe-8b2a-7caafc95864e Giacomini, A. (Arianna)\|\|\|/items/9dc5e35a-4a80-4b45-800a-f68dd6e44591 Ronca, R. (Roberto)\|\|\|/items/67c5e0cd-5fc0-4a83-93b5-e95b3b559415 Chiarini, M. (Marco)\|\|\|/items/0938193d-fabf-48b3-a5a2-81e7a547869e Imberti, L. (Luisa)\|\|\|/items/ce877e35-3265-49c7-b7ed-aeec1ec81119 Marini, M. (Mirella)\|\|\|/items/5cf09148-1faa-4589-a8df-58aea5658800 Rossi, G. (Giuseppe)\|\|\|/items/43494569-46e0-4c6f-9541-ad5da3d5c923 Presta, M. (Marco)\|\|\|/items/bf4f1122-25dd-442d-bee5-aaa6dcb37b0b Paiva, B. (Bruno)\|\|\|/items/b2c3efc5-27e1-4425-b452-efba1522c1d5 Roccaro, A.M. (Aldo M.)\|\|\|/items/a520dfdf-e922-49ed-b8f8-dc4cc5bf51f1
author2_role	author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Multiple myeloma Plasma Cell dyscrasia miRNAs Circulating miRNAs Circulating exosomal-miRNAs
topic	Multiple myeloma Plasma Cell dyscrasia miRNAs Circulating miRNAs Circulating exosomal-miRNAs
description	Multiple myeloma (MM) is a plasma cell dyscrasia characterized by bone marrow infiltration of clonal plasma cells. The recent literature has clearly demonstrated clonal heterogeneity in terms of both the genomic and transcriptomic signature of the tumor. Of note, novel studies have also highlighted the importance of the functional cross-talk between the tumor clone and the surrounding bone marrow milieu, as a relevant player of MM pathogenesis. These findings have certainly enhanced our understanding of the underlying mechanisms supporting MM pathogenesis and disease progression. Within the specific field of small non-coding RNA-research, recent studies have provided evidence for considering microRNAs as a crucial regulator of MM biology and, in this context, circulating microRNAs have been shown to potentially contribute to prognostic stratification of MM patients. The present review will summarize the most recent studies within the specific topic of microRNAs and circulating microRNAs in MM.
publishDate	2019
dc.date.none.fl_str_mv	2019 2019-01-01 2019 2019-01-01 2021 2021-11-02
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/62297
url	https://hdl.handle.net/10171/62297
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	MDPI AG
publisher.none.fl_str_mv	MDPI AG
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Circulating microRNAs and their role in multiple myeloma

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