Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis

Forty-three patients with cirrhosis and ascites, 21 with normal renal function, 10 with a progressive functional renal failure (FRF), and 12 with a steady FRF, were investigated for the presence of endotoxaemia by the Limulus lysate test. Endotoxaemia was found in nine patients with FRF and in none...

ver descrição completa

Detalhes bibliográficos
Autores: Clemente, C., Bosch i Genover, Jaume, Rodés, J., Arroyo, Vicente, Mas Comas, Ana M., Maragall, S.
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:1977
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/18642
Acesso em linha:https://hdl.handle.net/2445/18642
Access Level:Acceso aberto
Palavra-chave:Insuficiència renal aguda
Cirrosi hepàtica
Hemorràgia gastrointestinal
Endotoxines
Gastritis
Hepatic cirrhosis
Acute renal failure
Gastrointestinal hemorrhage
Endotoxins
id ES_586cabdce7a1a685040a8b21f4fa2432
oai_identifier_str oai:recercat.cat:2445/18642
network_acronym_str ES
network_name_str España
repository_id_str
spelling Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosisClemente, C.Bosch i Genover, JaumeRodés, J.Arroyo, VicenteMas Comas, Ana M.Maragall, S.Insuficiència renal agudaCirrosi hepàticaHemorràgia gastrointestinalEndotoxinesGastritisHepatic cirrhosisAcute renal failureGastritisGastrointestinal hemorrhageEndotoxinsForty-three patients with cirrhosis and ascites, 21 with normal renal function, 10 with a progressive functional renal failure (FRF), and 12 with a steady FRF, were investigated for the presence of endotoxaemia by the Limulus lysate test. Endotoxaemia was found in nine patients with FRF and in none of the 21 with normal renal function (P less than 0-01). A positive Limulus test was almost exclusively associated with a progressive FRF (eight of 10 patients) and all but one of them died. Renal function improved as endotoxaemia disappeared in the survivor. Endotoxaemia was also associated with haemorrhage due to acute erosions of the gastric mucosa, being present in six of the seven patients who had this complication. Intravascular coagulation was not found in any patient. The Limulus test was positive in the ascitic fluid in 18 of 21 patients tested, although only two of them had peritonitis. These results suggest that endotoxaemia may play a critical role in the development of progressive renal failure and haemorrhagic gastritis in cirrhosis, and emphasise the potential risk of procedures involving reinfusion of ascitic fluid.BMJ Group201120111977info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion5 p.application/pdfhttps://hdl.handle.net/2445/18642Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.18.7.556Gut, 1977, vol. 18, núm. 7, p. 556-560http://dx.doi.org/10.1136/gut.18.7.556(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1977info:eu-repo/semantics/openAccessoai:recercat.cat:2445/186422026-05-29T05:05:01Z
dc.title.none.fl_str_mv Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
title Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
spellingShingle Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
Clemente, C.
Insuficiència renal aguda
Cirrosi hepàtica
Hemorràgia gastrointestinal
Endotoxines
Gastritis
Hepatic cirrhosis
Acute renal failure
Gastritis
Gastrointestinal hemorrhage
Endotoxins
title_short Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
title_full Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
title_fullStr Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
title_full_unstemmed Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
title_sort Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
dc.creator.none.fl_str_mv Clemente, C.
Bosch i Genover, Jaume
Rodés, J.
Arroyo, Vicente
Mas Comas, Ana M.
Maragall, S.
author Clemente, C.
author_facet Clemente, C.
Bosch i Genover, Jaume
Rodés, J.
Arroyo, Vicente
Mas Comas, Ana M.
Maragall, S.
author_role author
author2 Bosch i Genover, Jaume
Rodés, J.
Arroyo, Vicente
Mas Comas, Ana M.
Maragall, S.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Insuficiència renal aguda
Cirrosi hepàtica
Hemorràgia gastrointestinal
Endotoxines
Gastritis
Hepatic cirrhosis
Acute renal failure
Gastritis
Gastrointestinal hemorrhage
Endotoxins
topic Insuficiència renal aguda
Cirrosi hepàtica
Hemorràgia gastrointestinal
Endotoxines
Gastritis
Hepatic cirrhosis
Acute renal failure
Gastritis
Gastrointestinal hemorrhage
Endotoxins
description Forty-three patients with cirrhosis and ascites, 21 with normal renal function, 10 with a progressive functional renal failure (FRF), and 12 with a steady FRF, were investigated for the presence of endotoxaemia by the Limulus lysate test. Endotoxaemia was found in nine patients with FRF and in none of the 21 with normal renal function (P less than 0-01). A positive Limulus test was almost exclusively associated with a progressive FRF (eight of 10 patients) and all but one of them died. Renal function improved as endotoxaemia disappeared in the survivor. Endotoxaemia was also associated with haemorrhage due to acute erosions of the gastric mucosa, being present in six of the seven patients who had this complication. Intravascular coagulation was not found in any patient. The Limulus test was positive in the ascitic fluid in 18 of 21 patients tested, although only two of them had peritonitis. These results suggest that endotoxaemia may play a critical role in the development of progressive renal failure and haemorrhagic gastritis in cirrhosis, and emphasise the potential risk of procedures involving reinfusion of ascitic fluid.
publishDate 1977
dc.date.none.fl_str_mv 1977
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/18642
url https://hdl.handle.net/2445/18642
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.18.7.556
Gut, 1977, vol. 18, núm. 7, p. 556-560
http://dx.doi.org/10.1136/gut.18.7.556
dc.rights.none.fl_str_mv (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1977
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1977
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5 p.
application/pdf
dc.publisher.none.fl_str_mv BMJ Group
publisher.none.fl_str_mv BMJ Group
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408541507321856
score 15,81155

Registros relacionados