Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans

Probiotics with high bile salt hydrolase (BSH) activity have shown to promote cardiovascular health. However, their mechanism(s) of action remain poorly understood. Here, we performed a pilot exploratory study to investigate effects of a 4-week intervention with escalating doses of a BSH-active form...

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Autores: Padró, Teresa|||0000-0003-1921-954X, de Santisteban, Victoria Marta|||0000-0003-0623-031X, Huedo Moreno, Pol|||0000-0002-2933-0586, Puntes, Montserrat, Aguiló, Meritxell|||0000-0001-5367-8737, Espadaler Mazo, Jordi|||0000-0002-0128-8363, Badimon, Lina|||0000-0002-9162-2459
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:298703
Acceso en línea:https://ddd.uab.cat/record/298703
https://dx.doi.org/urn:doi:10.1093/cvr/cvae061
Access Level:acceso abierto
Palabra clave:ApoB
Bile acid deconjugation
LDL oxidative capacity
Microbiota
Small LDL
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spelling Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humansPadró, Teresa|||0000-0003-1921-954Xde Santisteban, Victoria Marta|||0000-0003-0623-031XHuedo Moreno, Pol|||0000-0002-2933-0586Puntes, MontserratAguiló, Meritxell|||0000-0001-5367-8737Espadaler Mazo, Jordi|||0000-0002-0128-8363Badimon, Lina|||0000-0002-9162-2459ApoBBile acid deconjugationLDL oxidative capacityMicrobiotaSmall LDLProbiotics with high bile salt hydrolase (BSH) activity have shown to promote cardiovascular health. However, their mechanism(s) of action remain poorly understood. Here, we performed a pilot exploratory study to investigate effects of a 4-week intervention with escalating doses of a BSH-active formula containing Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 on bile acid (BA), lipid profile, and lipoprotein function. Healthy overweight individuals were included in this study. The probiotic intake was associated with a progressive decrease of conjugated BAs in serum, due to the reduction of tauro- and glyco-conjugated forms. Plasma levels of fibroblast growth factor-19 were significantly reduced and correlated with BA changes. The probiotic induced significant changes in serum lipids, with reduction in non-HDL cholesterol (non-HDLc) and LDL cholesterol (LDLc) levels. The largest decrease was evidenced in the subgroup with higher baseline LDLc levels (LDLc.Universitat Autònoma de Barcelona 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/298703https://dx.doi.org/urn:doi:10.1093/cvr/cvae061reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-107160RB-I00Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/01687open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2987032026-06-06T12:50:31Z
dc.title.none.fl_str_mv Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans
title Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans
spellingShingle Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans
Padró, Teresa|||0000-0003-1921-954X
ApoB
Bile acid deconjugation
LDL oxidative capacity
Microbiota
Small LDL
title_short Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans
title_full Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans
title_fullStr Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans
title_full_unstemmed Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans
title_sort Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans
dc.creator.none.fl_str_mv Padró, Teresa|||0000-0003-1921-954X
de Santisteban, Victoria Marta|||0000-0003-0623-031X
Huedo Moreno, Pol|||0000-0002-2933-0586
Puntes, Montserrat
Aguiló, Meritxell|||0000-0001-5367-8737
Espadaler Mazo, Jordi|||0000-0002-0128-8363
Badimon, Lina|||0000-0002-9162-2459
author Padró, Teresa|||0000-0003-1921-954X
author_facet Padró, Teresa|||0000-0003-1921-954X
de Santisteban, Victoria Marta|||0000-0003-0623-031X
Huedo Moreno, Pol|||0000-0002-2933-0586
Puntes, Montserrat
Aguiló, Meritxell|||0000-0001-5367-8737
Espadaler Mazo, Jordi|||0000-0002-0128-8363
Badimon, Lina|||0000-0002-9162-2459
author_role author
author2 de Santisteban, Victoria Marta|||0000-0003-0623-031X
Huedo Moreno, Pol|||0000-0002-2933-0586
Puntes, Montserrat
Aguiló, Meritxell|||0000-0001-5367-8737
Espadaler Mazo, Jordi|||0000-0002-0128-8363
Badimon, Lina|||0000-0002-9162-2459
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv ApoB
Bile acid deconjugation
LDL oxidative capacity
Microbiota
Small LDL
topic ApoB
Bile acid deconjugation
LDL oxidative capacity
Microbiota
Small LDL
description Probiotics with high bile salt hydrolase (BSH) activity have shown to promote cardiovascular health. However, their mechanism(s) of action remain poorly understood. Here, we performed a pilot exploratory study to investigate effects of a 4-week intervention with escalating doses of a BSH-active formula containing Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 on bile acid (BA), lipid profile, and lipoprotein function. Healthy overweight individuals were included in this study. The probiotic intake was associated with a progressive decrease of conjugated BAs in serum, due to the reduction of tauro- and glyco-conjugated forms. Plasma levels of fibroblast growth factor-19 were significantly reduced and correlated with BA changes. The probiotic induced significant changes in serum lipids, with reduction in non-HDL cholesterol (non-HDLc) and LDL cholesterol (LDLc) levels. The largest decrease was evidenced in the subgroup with higher baseline LDLc levels (LDLc.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/298703
https://dx.doi.org/urn:doi:10.1093/cvr/cvae061
url https://ddd.uab.cat/record/298703
https://dx.doi.org/urn:doi:10.1093/cvr/cvae061
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-107160RB-I00
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/01687
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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