Deregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma
In the present work, we show that T-cell lymphoblastic lymphoma cells exhibit a reduction of FADD availability in the cytoplasm, which may contribute to impaired apoptosis. In addition, we observe a reduction of FADD phosphorylation that inversely correlates with the proliferation capacity and tumor...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/735740 |
| Acceso en línea: | https://hdl.handle.net/10486/735740 https://dx.doi.org/10.18632/oncotarget.11370 |
| Access Level: | acceso abierto |
| Palabra clave: | T-cell lymphoblastic lymphoma Fas-associated death domain protein (FADD) expression and phosphorylation tumor aggressiveness prognostic marker Biología y Biomedicina / Biología |
| Sumario: | In the present work, we show that T-cell lymphoblastic lymphoma cells exhibit a reduction of FADD availability in the cytoplasm, which may contribute to impaired apoptosis. In addition, we observe a reduction of FADD phosphorylation that inversely correlates with the proliferation capacity and tumor aggressiveness. The resultant balance between FADD-dependent apoptotic and non-apoptotic abilities may define the outcome of the tumor. Thus, we propose that FADD expression and phosphorylation can be reliable biomarkers with prognostic value for T-LBL stratification |
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