Potential threat to Eurasian griffon vultures in Spain from veterinary use of the drug diclofenac

1. Spain holds > 95% of the European breeding population of the Eurasian griffon vulture Gyps fulvus. Vultures provide important ecosystem services in carcass removal and influence emissions of greenhouse gases. Despite the known toxicity of the non-steroidal anti-inflammatory drug diclofenac to...

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Autores: Green, Rhys E., Donázar, José Antonio, Sánchez Zapata, José Antonio, Margalida, Antoni
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad Miguel Hernández de Elche
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/6002
Acceso en línea:http://hdl.handle.net/11000/6002
Access Level:acceso abierto
Palabra clave:avian scavengers
diclofenac
ecosystem services
Eurasian griffon vulture Gyps fulvus
population dynamics
simulation model
veterinary drugs
573 - Biología general y teórica
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spelling Potential threat to Eurasian griffon vultures in Spain from veterinary use of the drug diclofenacGreen, Rhys E.Donázar, José AntonioSánchez Zapata, José AntonioMargalida, Antoniavian scavengersdiclofenacecosystem servicesEurasian griffon vulture Gyps fulvuspopulation dynamicssimulation modelveterinary drugs573 - Biología general y teórica1. Spain holds > 95% of the European breeding population of the Eurasian griffon vulture Gyps fulvus. Vultures provide important ecosystem services in carcass removal and influence emissions of greenhouse gases. Despite the known toxicity of the non-steroidal anti-inflammatory drug diclofenac to this species and other Gyps vultures, in March 2013 the Agencia Espa~nola de Medicamentos y Productos Sanitarios (AEMPS) approved the use of two medicines containing diclofenac for veterinary use in horses, pigs and cattle in Spain. 2. To assess the potential impact of medicated ungulate carcasses on Eurasian griffon vulture populations in Spain, we first used information on the metabolism and elimination of diclofenac from medicated cattle and pigs to calculate residue levels in relation to time elapsed between dosing and death. Secondly, probabilities of the death of a vulture per meal were calculated based upon experimental studies of diclofenac toxicity. Finally, annual numbers of vulture deaths expected to be caused by diclofenac were obtained by multiplying the death rates per meal by the estimated numbers of vulture meals taken from expected numbers of medicated carcasses suggested by AEMPS. 3. Assuming that vultures feed on carcasses that were treated with diclofenac 8 h before the animal’s death, the annual number of vulture deaths caused by diclofenac was estimated at 715–6389, depending upon the estimate of numbers of medicated carcasses assumed and the version of the dose–response model used. Using a density-independent simulation model of a vulture population, the expected rate of decline of the Spanish population of Eurasian griffon vultures caused by these deaths is 0_9–7_7% per year. A density-dependent simulation model also indicated substantial population-level effects. Formal estimates of precision and sensitivity analyses of effects of unmeasured variables highlight the uncertainty of estimates using currently available data. 4. Synthesis and applications. Due to the possibility of causing an important impact on vulture populations, our findings justify a precautionary ban on the veterinary use of diclofenac in Spain and encourage the use of meloxicam, a vulture-safe alternative drug. A programme of monitoring of non-steroidal anti-inflammatory drug contamination of ungulate carcasses available to vultures and of moribund and dead obligate and facultative avian scavengers would be needed to be confident that a damaging level of contamination is not present.Ministry of Economy and Competitiveness. Grant Numbers: RYC‐2012‐11867, CGL2012‐40013‐CO2‐01‐02, CGL2015‐66966‐C2‐1‐2‐RDepartamentos de la UMH::Biología Aplicada2020202020162020info:eu-repo/semantics/articleapplication/pdf11application/pdfhttp://hdl.handle.net/11000/6002reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheIngléshttps://doi.org/10.1111/1365-2664.12663info:eu-repo/semantics/openAccessoai:dspace.umh.es:11000/60022026-05-27T13:36:21Z
dc.title.none.fl_str_mv Potential threat to Eurasian griffon vultures in Spain from veterinary use of the drug diclofenac
title Potential threat to Eurasian griffon vultures in Spain from veterinary use of the drug diclofenac
spellingShingle Potential threat to Eurasian griffon vultures in Spain from veterinary use of the drug diclofenac
Green, Rhys E.
avian scavengers
diclofenac
ecosystem services
Eurasian griffon vulture Gyps fulvus
population dynamics
simulation model
veterinary drugs
573 - Biología general y teórica
title_short Potential threat to Eurasian griffon vultures in Spain from veterinary use of the drug diclofenac
title_full Potential threat to Eurasian griffon vultures in Spain from veterinary use of the drug diclofenac
title_fullStr Potential threat to Eurasian griffon vultures in Spain from veterinary use of the drug diclofenac
title_full_unstemmed Potential threat to Eurasian griffon vultures in Spain from veterinary use of the drug diclofenac
title_sort Potential threat to Eurasian griffon vultures in Spain from veterinary use of the drug diclofenac
dc.creator.none.fl_str_mv Green, Rhys E.
Donázar, José Antonio
Sánchez Zapata, José Antonio
Margalida, Antoni
author Green, Rhys E.
author_facet Green, Rhys E.
Donázar, José Antonio
Sánchez Zapata, José Antonio
Margalida, Antoni
author_role author
author2 Donázar, José Antonio
Sánchez Zapata, José Antonio
Margalida, Antoni
author2_role author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Biología Aplicada
dc.subject.none.fl_str_mv avian scavengers
diclofenac
ecosystem services
Eurasian griffon vulture Gyps fulvus
population dynamics
simulation model
veterinary drugs
573 - Biología general y teórica
topic avian scavengers
diclofenac
ecosystem services
Eurasian griffon vulture Gyps fulvus
population dynamics
simulation model
veterinary drugs
573 - Biología general y teórica
description 1. Spain holds > 95% of the European breeding population of the Eurasian griffon vulture Gyps fulvus. Vultures provide important ecosystem services in carcass removal and influence emissions of greenhouse gases. Despite the known toxicity of the non-steroidal anti-inflammatory drug diclofenac to this species and other Gyps vultures, in March 2013 the Agencia Espa~nola de Medicamentos y Productos Sanitarios (AEMPS) approved the use of two medicines containing diclofenac for veterinary use in horses, pigs and cattle in Spain. 2. To assess the potential impact of medicated ungulate carcasses on Eurasian griffon vulture populations in Spain, we first used information on the metabolism and elimination of diclofenac from medicated cattle and pigs to calculate residue levels in relation to time elapsed between dosing and death. Secondly, probabilities of the death of a vulture per meal were calculated based upon experimental studies of diclofenac toxicity. Finally, annual numbers of vulture deaths expected to be caused by diclofenac were obtained by multiplying the death rates per meal by the estimated numbers of vulture meals taken from expected numbers of medicated carcasses suggested by AEMPS. 3. Assuming that vultures feed on carcasses that were treated with diclofenac 8 h before the animal’s death, the annual number of vulture deaths caused by diclofenac was estimated at 715–6389, depending upon the estimate of numbers of medicated carcasses assumed and the version of the dose–response model used. Using a density-independent simulation model of a vulture population, the expected rate of decline of the Spanish population of Eurasian griffon vultures caused by these deaths is 0_9–7_7% per year. A density-dependent simulation model also indicated substantial population-level effects. Formal estimates of precision and sensitivity analyses of effects of unmeasured variables highlight the uncertainty of estimates using currently available data. 4. Synthesis and applications. Due to the possibility of causing an important impact on vulture populations, our findings justify a precautionary ban on the veterinary use of diclofenac in Spain and encourage the use of meloxicam, a vulture-safe alternative drug. A programme of monitoring of non-steroidal anti-inflammatory drug contamination of ungulate carcasses available to vultures and of moribund and dead obligate and facultative avian scavengers would be needed to be confident that a damaging level of contamination is not present.
publishDate 2016
dc.date.none.fl_str_mv 2016
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11000/6002
url http://hdl.handle.net/11000/6002
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1111/1365-2664.12663
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
11
application/pdf
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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