Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical Perspective

Aβ peptides are known to bind neural plasma membranes in a process leading to the deposit of Aβ-enriched plaques. These extracellular structures are characteristic of Alzheimer's disease, the major cause of late-age dementia. The mechanisms of Aβ plaque formation and deposition are far from bei...

Descripción completa

Detalles Bibliográficos
Autores: Ahyayauch, Hasna, Masserini, Massimo, Alonso, Alicia, Goñi, Félix M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/373287
Acceso en línea:http://hdl.handle.net/10261/373287
https://api.elsevier.com/content/abstract/scopus_id/85197247745
Access Level:acceso abierto
Palabra clave:Aβ42
β-amyloid
Aβ membrane binding
Ganglioside
Sphingomyelin
Cholesterol
Isothermal calorimetry
Langmuir balance
Alzheimer’s disease
id ES_581a86355cf0efbd33029a06bee349c4
oai_identifier_str oai:digital.csic.es:10261/373287
network_acronym_str ES
network_name_str España
repository_id_str
spelling Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical PerspectiveAhyayauch, HasnaMasserini, MassimoAlonso, AliciaGoñi, Félix M.Aβ42β-amyloidAβ membrane bindingGangliosideSphingomyelinCholesterolIsothermal calorimetryLangmuir balanceAlzheimer’s diseaseAβ peptides are known to bind neural plasma membranes in a process leading to the deposit of Aβ-enriched plaques. These extracellular structures are characteristic of Alzheimer's disease, the major cause of late-age dementia. The mechanisms of Aβ plaque formation and deposition are far from being understood. A vast number of studies in the literature describe the efforts to analyze those mechanisms using a variety of tools. The present review focuses on biophysical studies mostly carried out with model membranes or with computational tools. This review starts by describing basic physical aspects of lipid phases and commonly used model membranes (monolayers and bilayers). This is followed by a discussion of the biophysical techniques applied to these systems, mainly but not exclusively Langmuir monolayers, isothermal calorimetry, density-gradient ultracentrifugation, and molecular dynamics. The Methodological Section is followed by the core of the review, which includes a summary of important results obtained with each technique. The last section is devoted to an overall reflection and an effort to understand Aβ-bilayer binding. Concepts such as Aβ peptide membrane binding, adsorption, and insertion are defined and differentiated. The roles of membrane lipid order, nanodomain formation, and electrostatic forces in Aβ-membrane interaction are separately identified and discussed.This work was funded in part by the Spanish Ministry of Science, Innovation, and Universities (MCIU), Agencia Estatal de Investigación (AEI), Fondo Europeo de Desarrollo Regional (FEDER) (grant No. PID2021-124461NB-I00), the Basque Government (grant No. IT1625-22), Fundación Ramón Areces (CIVP20A6619), Fundación Biofísica Bizkaia, and the Basque Excellence Research Centre (BERC) program of the Basque Government.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionEusko JaurlaritzaAlonso, Alicia [0000-0002-2730-7470]Goñi, Félix M. [0000-0001-6270-9216]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/373287https://api.elsevier.com/content/abstract/scopus_id/85197247745reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-124461NB-I00http://dx.doi.org/10.3390/ijms25126401Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3732872026-05-22T06:33:51Z
dc.title.none.fl_str_mv Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical Perspective
title Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical Perspective
spellingShingle Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical Perspective
Ahyayauch, Hasna
Aβ42
β-amyloid
Aβ membrane binding
Ganglioside
Sphingomyelin
Cholesterol
Isothermal calorimetry
Langmuir balance
Alzheimer’s disease
title_short Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical Perspective
title_full Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical Perspective
title_fullStr Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical Perspective
title_full_unstemmed Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical Perspective
title_sort Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical Perspective
dc.creator.none.fl_str_mv Ahyayauch, Hasna
Masserini, Massimo
Alonso, Alicia
Goñi, Félix M.
author Ahyayauch, Hasna
author_facet Ahyayauch, Hasna
Masserini, Massimo
Alonso, Alicia
Goñi, Félix M.
author_role author
author2 Masserini, Massimo
Alonso, Alicia
Goñi, Félix M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Eusko Jaurlaritza
Alonso, Alicia [0000-0002-2730-7470]
Goñi, Félix M. [0000-0001-6270-9216]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Aβ42
β-amyloid
Aβ membrane binding
Ganglioside
Sphingomyelin
Cholesterol
Isothermal calorimetry
Langmuir balance
Alzheimer’s disease
topic Aβ42
β-amyloid
Aβ membrane binding
Ganglioside
Sphingomyelin
Cholesterol
Isothermal calorimetry
Langmuir balance
Alzheimer’s disease
description Aβ peptides are known to bind neural plasma membranes in a process leading to the deposit of Aβ-enriched plaques. These extracellular structures are characteristic of Alzheimer's disease, the major cause of late-age dementia. The mechanisms of Aβ plaque formation and deposition are far from being understood. A vast number of studies in the literature describe the efforts to analyze those mechanisms using a variety of tools. The present review focuses on biophysical studies mostly carried out with model membranes or with computational tools. This review starts by describing basic physical aspects of lipid phases and commonly used model membranes (monolayers and bilayers). This is followed by a discussion of the biophysical techniques applied to these systems, mainly but not exclusively Langmuir monolayers, isothermal calorimetry, density-gradient ultracentrifugation, and molecular dynamics. The Methodological Section is followed by the core of the review, which includes a summary of important results obtained with each technique. The last section is devoted to an overall reflection and an effort to understand Aβ-bilayer binding. Concepts such as Aβ peptide membrane binding, adsorption, and insertion are defined and differentiated. The roles of membrane lipid order, nanodomain formation, and electrostatic forces in Aβ-membrane interaction are separately identified and discussed.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/373287
https://api.elsevier.com/content/abstract/scopus_id/85197247745
url http://hdl.handle.net/10261/373287
https://api.elsevier.com/content/abstract/scopus_id/85197247745
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-124461NB-I00
http://dx.doi.org/10.3390/ijms25126401
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408509348544512
score 15,811543

Similares en LA Referencia