Deciphering the interplay between autophagy and polarity in epithelial tubulogenesis

The Metazoan complexity arises from a primary building block, the epithelium, which comprises a layer of polarized cells that divide the organism into compartments. Most of these body compartments are organs formed by epithelial tubes that enclose an internal hollow space or lumen. Over the last dec...

ver descrição completa

Detalhes bibliográficos
Autores: Alfonso-Pérez, Tatiana, Baonza, Gabriel, Herranz, Gonzalo, Martín-Belmonte, Fernando
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/367570
Acesso em linha:http://hdl.handle.net/10261/367570
Access Level:Acceso aberto
Palavra-chave:Autophagy
Epithelial
Lumenogenesis
Polarity
Polarized transport.
id ES_580d3e0342e4e9bb04e407ce208eadcc
oai_identifier_str oai:digital.csic.es:10261/367570
network_acronym_str ES
network_name_str España
repository_id_str
spelling Deciphering the interplay between autophagy and polarity in epithelial tubulogenesisAlfonso-Pérez, TatianaBaonza, GabrielHerranz, GonzaloMartín-Belmonte, FernandoAutophagyEpithelialLumenogenesisPolarityPolarized transport.The Metazoan complexity arises from a primary building block, the epithelium, which comprises a layer of polarized cells that divide the organism into compartments. Most of these body compartments are organs formed by epithelial tubes that enclose an internal hollow space or lumen. Over the last decades, multiple studies have unmasked the paramount events required to form this lumen de novo. In epithelial cells, these events mainly involve recognizing external clues, establishing and maintaining apicobasal polarity, endo-lysosomal trafficking, and expanding the created lumen. Although canonical autophagy has been classically considered a catabolic process needed for cell survival, multiple studies have also emphasized its crucial role in epithelial polarity, morphogenesis and cellular homeostasis. Furthermore, non-canonical autophagy pathways have been recently discovered as atypical secretory routes. Both canonical and non-canonical pathways play essential roles in epithelial polarity and lumen formation. This review addresses how the molecular machinery for epithelial polarity and autophagy interplay in different processes and how autophagy functions influence lumenogenesis, emphasizing its role in the lumen formation key events.T.A.P. was supported by a Juan de la Cierva grant from MICINN. G.B. was supported by a Comunidad de Madrid contract (CAM). G.H. was supported by a FPI grant from MINECO (BES-2018-077789). F.M.B. was supported by MICINN (PID2020-120367GB-I00), and Fundación Ramón Areces (CIVP18A3904).Academic PressMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Fundación Ramón ArecesMinisterio de Economía y Competitividad (España)Comunidad de MadridConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420222024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/367570reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//BES-2018-077789info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-120367GB-I00http://dx.doi.org/10.1016/j.semcdb.2022.05.015Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3675702026-05-22T06:33:51Z
dc.title.none.fl_str_mv Deciphering the interplay between autophagy and polarity in epithelial tubulogenesis
title Deciphering the interplay between autophagy and polarity in epithelial tubulogenesis
spellingShingle Deciphering the interplay between autophagy and polarity in epithelial tubulogenesis
Alfonso-Pérez, Tatiana
Autophagy
Epithelial
Lumenogenesis
Polarity
Polarized transport.
title_short Deciphering the interplay between autophagy and polarity in epithelial tubulogenesis
title_full Deciphering the interplay between autophagy and polarity in epithelial tubulogenesis
title_fullStr Deciphering the interplay between autophagy and polarity in epithelial tubulogenesis
title_full_unstemmed Deciphering the interplay between autophagy and polarity in epithelial tubulogenesis
title_sort Deciphering the interplay between autophagy and polarity in epithelial tubulogenesis
dc.creator.none.fl_str_mv Alfonso-Pérez, Tatiana
Baonza, Gabriel
Herranz, Gonzalo
Martín-Belmonte, Fernando
author Alfonso-Pérez, Tatiana
author_facet Alfonso-Pérez, Tatiana
Baonza, Gabriel
Herranz, Gonzalo
Martín-Belmonte, Fernando
author_role author
author2 Baonza, Gabriel
Herranz, Gonzalo
Martín-Belmonte, Fernando
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Fundación Ramón Areces
Ministerio de Economía y Competitividad (España)
Comunidad de Madrid
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Autophagy
Epithelial
Lumenogenesis
Polarity
Polarized transport.
topic Autophagy
Epithelial
Lumenogenesis
Polarity
Polarized transport.
description The Metazoan complexity arises from a primary building block, the epithelium, which comprises a layer of polarized cells that divide the organism into compartments. Most of these body compartments are organs formed by epithelial tubes that enclose an internal hollow space or lumen. Over the last decades, multiple studies have unmasked the paramount events required to form this lumen de novo. In epithelial cells, these events mainly involve recognizing external clues, establishing and maintaining apicobasal polarity, endo-lysosomal trafficking, and expanding the created lumen. Although canonical autophagy has been classically considered a catabolic process needed for cell survival, multiple studies have also emphasized its crucial role in epithelial polarity, morphogenesis and cellular homeostasis. Furthermore, non-canonical autophagy pathways have been recently discovered as atypical secretory routes. Both canonical and non-canonical pathways play essential roles in epithelial polarity and lumen formation. This review addresses how the molecular machinery for epithelial polarity and autophagy interplay in different processes and how autophagy functions influence lumenogenesis, emphasizing its role in the lumen formation key events.
publishDate 2022
dc.date.none.fl_str_mv 2022
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/367570
url http://hdl.handle.net/10261/367570
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//BES-2018-077789
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-120367GB-I00
http://dx.doi.org/10.1016/j.semcdb.2022.05.015
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Academic Press
publisher.none.fl_str_mv Academic Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408505586253825
score 15.812455

Registros relacionados