High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria.

Background Malaria immunity is commonly believed to wane in the absence of Plasmodium falciparum exposure, based on limited epidemiological data and short-lived antibody responses in some longitudinal studies in endemic areas. Methods A cross-sectional study was conducted among sub-Saharan African a...

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Autores: Moncunill Piñas, Gemma, Mayor Aparicio, Alfredo Gabriel, Jiménez, Alfons, Nhabomba, Augusto J., Casas-Vila, Núria, Puyol, Laura, Campo, Joseph J., Manaca, Maria Nélia, Aguilar, Ruth, Pinazo, Maria-Jesus, Almirall, Mercè, Soler, Cristina, Muñoz, José, Bardají, Azucena, Angov, Evelina, Dutta, Sheetij, Chitnis, Chetan E., Alonso, Pedro, Gascón i Brustenga, Joaquim, Dobaño, Carlota, 1969-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/121777
Acceso en línea:https://hdl.handle.net/2445/121777
Access Level:acceso abierto
Palabra clave:Immunoglobulines
Plasmodium falciparum
Immigrants
Malària
Immunoglobulins
Malaria
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spelling High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria.Moncunill Piñas, GemmaMayor Aparicio, Alfredo GabrielJiménez, AlfonsNhabomba, Augusto J.Casas-Vila, NúriaPuyol, LauraCampo, Joseph J.Manaca, Maria NéliaAguilar, RuthPinazo, Maria-JesusAlmirall, MercèSoler, CristinaMuñoz, JoséBardají, AzucenaAngov, EvelinaDutta, SheetijChitnis, Chetan E.Alonso, PedroGascón i Brustenga, JoaquimDobaño, Carlota, 1969-ImmunoglobulinesPlasmodium falciparumImmigrantsMalàriaImmunoglobulinsPlasmodium falciparumImmigrantsMalariaBackground Malaria immunity is commonly believed to wane in the absence of Plasmodium falciparum exposure, based on limited epidemiological data and short-lived antibody responses in some longitudinal studies in endemic areas. Methods A cross-sectional study was conducted among sub-Saharan African adults residing in Spain for 1 up to 38 years (immigrants) with clinical malaria (n=55) or without malaria (n=37), naïve adults (travelers) with a first clinical malaria episode (n=20) and life-long malaria exposed adults from Mozambique (semi-immune adults) without malaria (n=27) or with clinical malaria (n=50). Blood samples were collected and IgG levels against the erythrocytic antigens AMA-1 and MSP-142 (3D7 and FVO strains), EBA-175 and DBL-α were determined by Luminex. IgG levels against antigens on the surface of infected erythrocytes (IEs) were measured by flow cytometry. Results Immigrants without malaria had lower IgG levels than healthy semi-immune adults regardless of the antigen tested (P≤0.026), but no correlation was found between IgG levels and time since migration. Upon reinfection, immigrants with malaria had higher levels of IgG against all antigens than immigrants without malaria. However, the magnitude of the response compared to semi-immune adults with malaria depended on the antigen tested. Thus, immigrants had higher IgG levels against AMA-1 and MSP-142 (P≤0.015), similar levels against EBA-175 and DBL-α, and lower levels against IEs (P≤0.016). Immigrants had higher IgG levels against all antigens tested compared to travelers (P≤0.001), both with malaria. Conclusions Upon cessation of malaria exposure, IgG responses to malaria-specific antigens were maintained to a large extent, although the conservation and the magnitude of the recall response depended on the nature of the antigen. Studies on immigrant populations can shed light on the factors that determine the duration of malaria specific antibody responses and its effect on protection, with important implications for future vaccine design and public health control measures.Public Library of Science (PLoS)2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/121777Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0073624PLoS One, 2013https://doi.org/10.1371/journal.pone.0073624cc-by (c) Moncunill, Gemma et al., 2013http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1217772026-05-27T06:46:51Z
dc.title.none.fl_str_mv High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria.
title High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria.
spellingShingle High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria.
Moncunill Piñas, Gemma
Immunoglobulines
Plasmodium falciparum
Immigrants
Malària
Immunoglobulins
Plasmodium falciparum
Immigrants
Malaria
title_short High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria.
title_full High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria.
title_fullStr High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria.
title_full_unstemmed High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria.
title_sort High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria.
dc.creator.none.fl_str_mv Moncunill Piñas, Gemma
Mayor Aparicio, Alfredo Gabriel
Jiménez, Alfons
Nhabomba, Augusto J.
Casas-Vila, Núria
Puyol, Laura
Campo, Joseph J.
Manaca, Maria Nélia
Aguilar, Ruth
Pinazo, Maria-Jesus
Almirall, Mercè
Soler, Cristina
Muñoz, José
Bardají, Azucena
Angov, Evelina
Dutta, Sheetij
Chitnis, Chetan E.
Alonso, Pedro
Gascón i Brustenga, Joaquim
Dobaño, Carlota, 1969-
author Moncunill Piñas, Gemma
author_facet Moncunill Piñas, Gemma
Mayor Aparicio, Alfredo Gabriel
Jiménez, Alfons
Nhabomba, Augusto J.
Casas-Vila, Núria
Puyol, Laura
Campo, Joseph J.
Manaca, Maria Nélia
Aguilar, Ruth
Pinazo, Maria-Jesus
Almirall, Mercè
Soler, Cristina
Muñoz, José
Bardají, Azucena
Angov, Evelina
Dutta, Sheetij
Chitnis, Chetan E.
Alonso, Pedro
Gascón i Brustenga, Joaquim
Dobaño, Carlota, 1969-
author_role author
author2 Mayor Aparicio, Alfredo Gabriel
Jiménez, Alfons
Nhabomba, Augusto J.
Casas-Vila, Núria
Puyol, Laura
Campo, Joseph J.
Manaca, Maria Nélia
Aguilar, Ruth
Pinazo, Maria-Jesus
Almirall, Mercè
Soler, Cristina
Muñoz, José
Bardají, Azucena
Angov, Evelina
Dutta, Sheetij
Chitnis, Chetan E.
Alonso, Pedro
Gascón i Brustenga, Joaquim
Dobaño, Carlota, 1969-
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Immunoglobulines
Plasmodium falciparum
Immigrants
Malària
Immunoglobulins
Plasmodium falciparum
Immigrants
Malaria
topic Immunoglobulines
Plasmodium falciparum
Immigrants
Malària
Immunoglobulins
Plasmodium falciparum
Immigrants
Malaria
description Background Malaria immunity is commonly believed to wane in the absence of Plasmodium falciparum exposure, based on limited epidemiological data and short-lived antibody responses in some longitudinal studies in endemic areas. Methods A cross-sectional study was conducted among sub-Saharan African adults residing in Spain for 1 up to 38 years (immigrants) with clinical malaria (n=55) or without malaria (n=37), naïve adults (travelers) with a first clinical malaria episode (n=20) and life-long malaria exposed adults from Mozambique (semi-immune adults) without malaria (n=27) or with clinical malaria (n=50). Blood samples were collected and IgG levels against the erythrocytic antigens AMA-1 and MSP-142 (3D7 and FVO strains), EBA-175 and DBL-α were determined by Luminex. IgG levels against antigens on the surface of infected erythrocytes (IEs) were measured by flow cytometry. Results Immigrants without malaria had lower IgG levels than healthy semi-immune adults regardless of the antigen tested (P≤0.026), but no correlation was found between IgG levels and time since migration. Upon reinfection, immigrants with malaria had higher levels of IgG against all antigens than immigrants without malaria. However, the magnitude of the response compared to semi-immune adults with malaria depended on the antigen tested. Thus, immigrants had higher IgG levels against AMA-1 and MSP-142 (P≤0.015), similar levels against EBA-175 and DBL-α, and lower levels against IEs (P≤0.016). Immigrants had higher IgG levels against all antigens tested compared to travelers (P≤0.001), both with malaria. Conclusions Upon cessation of malaria exposure, IgG responses to malaria-specific antigens were maintained to a large extent, although the conservation and the magnitude of the recall response depended on the nature of the antigen. Studies on immigrant populations can shed light on the factors that determine the duration of malaria specific antibody responses and its effect on protection, with important implications for future vaccine design and public health control measures.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/121777
url https://hdl.handle.net/2445/121777
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0073624
PLoS One, 2013
https://doi.org/10.1371/journal.pone.0073624
dc.rights.none.fl_str_mv cc-by (c) Moncunill, Gemma et al., 2013
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Moncunill, Gemma et al., 2013
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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