Preventive effect of a synbiotic combination of galacto- and fructooligosaccharides mixture with Bifidobacterium breve M-16V in a model of multiple rotavirus infections

Rotavirus (RV) causes morbidity and mortality among infants worldwide, and there is evidence that probiotics and prebiotics can have a positive influence against infective processes such as that due to RV. The aim of this study was to evidence a preventive role of one prebiotic mixture (of short-cha...

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Autores: Rigo Adrover, Maria del Mar, van Limpt, Kees, Knipping, K., Garssen, J., Knol, J., Costabile, Adele, Franch i Masferrer, Àngels, Castell, Margarida, Pérez-Cano, Francisco J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/130527
Acceso en línea:https://hdl.handle.net/2445/130527
Access Level:acceso abierto
Palabra clave:Prebiòtics
Probiòtics
Malalties intestinals
Prebiotics
Probiotics
Intestinal diseases
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spelling Preventive effect of a synbiotic combination of galacto- and fructooligosaccharides mixture with Bifidobacterium breve M-16V in a model of multiple rotavirus infectionsRigo Adrover, Maria del Marvan Limpt, KeesKnipping, K.Garssen, J.Knol, J.Costabile, AdeleFranch i Masferrer, ÀngelsCastell, MargaridaPérez-Cano, Francisco J.PrebiòticsProbiòticsMalalties intestinalsPrebioticsProbioticsIntestinal diseasesRotavirus (RV) causes morbidity and mortality among infants worldwide, and there is evidence that probiotics and prebiotics can have a positive influence against infective processes such as that due to RV. The aim of this study was to evidence a preventive role of one prebiotic mixture (of short-chain galactooligosaccharide/long-chain fructooligosaccharide), the probiotic Bifidobacterium breve M-16V and the combination of the prebiotic and the probiotic, as a synbiotic, in a suckling rat double-RV infection model. Hyperimmune bovine colostrum was used as protection control. The first infection was induced with RV SA11 and the second one with EDIM. Clinical variables and immune response were evaluated after both infections. Dietary interventions ameliorated clinical symptoms after the first infection. The prebiotic and the synbiotic significantly reduced viral shedding after the first infection, but all the interventions showed higher viral load than in the RV group after the second infection. All interventions modulated ex vivo antibody and cytokine production, gut wash cytokine levels and small intestine gene expression after both infections. In conclusion, a daily supplement of the products tested in this preclinical model is highly effective in preventing RV-induced diarrhea but allowing the boost of the early immune response for a future immune response against reinfection, suggesting that these components may be potential agents for modulating RV infection in infants. Keywords: prebiotic, probiotic, synbiotic, rotavirus, FOS, GOS, Bifidobacterium breveFrontiers Media2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/130527Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésInglésReproducció del document publicat a: https://doi.org/10.3389/fimmu.2018.01318Frontiers in Immunology, 2018, vol. 9, p. 1318https://doi.org/10.3389/fimmu.2018.01318cc-by (c) Rigo-Adrover, Mar et al., 2018http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1305272026-05-27T06:46:51Z
dc.title.none.fl_str_mv Preventive effect of a synbiotic combination of galacto- and fructooligosaccharides mixture with Bifidobacterium breve M-16V in a model of multiple rotavirus infections
title Preventive effect of a synbiotic combination of galacto- and fructooligosaccharides mixture with Bifidobacterium breve M-16V in a model of multiple rotavirus infections
spellingShingle Preventive effect of a synbiotic combination of galacto- and fructooligosaccharides mixture with Bifidobacterium breve M-16V in a model of multiple rotavirus infections
Rigo Adrover, Maria del Mar
Prebiòtics
Probiòtics
Malalties intestinals
Prebiotics
Probiotics
Intestinal diseases
title_short Preventive effect of a synbiotic combination of galacto- and fructooligosaccharides mixture with Bifidobacterium breve M-16V in a model of multiple rotavirus infections
title_full Preventive effect of a synbiotic combination of galacto- and fructooligosaccharides mixture with Bifidobacterium breve M-16V in a model of multiple rotavirus infections
title_fullStr Preventive effect of a synbiotic combination of galacto- and fructooligosaccharides mixture with Bifidobacterium breve M-16V in a model of multiple rotavirus infections
title_full_unstemmed Preventive effect of a synbiotic combination of galacto- and fructooligosaccharides mixture with Bifidobacterium breve M-16V in a model of multiple rotavirus infections
title_sort Preventive effect of a synbiotic combination of galacto- and fructooligosaccharides mixture with Bifidobacterium breve M-16V in a model of multiple rotavirus infections
dc.creator.none.fl_str_mv Rigo Adrover, Maria del Mar
van Limpt, Kees
Knipping, K.
Garssen, J.
Knol, J.
Costabile, Adele
Franch i Masferrer, Àngels
Castell, Margarida
Pérez-Cano, Francisco J.
author Rigo Adrover, Maria del Mar
author_facet Rigo Adrover, Maria del Mar
van Limpt, Kees
Knipping, K.
Garssen, J.
Knol, J.
Costabile, Adele
Franch i Masferrer, Àngels
Castell, Margarida
Pérez-Cano, Francisco J.
author_role author
author2 van Limpt, Kees
Knipping, K.
Garssen, J.
Knol, J.
Costabile, Adele
Franch i Masferrer, Àngels
Castell, Margarida
Pérez-Cano, Francisco J.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Prebiòtics
Probiòtics
Malalties intestinals
Prebiotics
Probiotics
Intestinal diseases
topic Prebiòtics
Probiòtics
Malalties intestinals
Prebiotics
Probiotics
Intestinal diseases
description Rotavirus (RV) causes morbidity and mortality among infants worldwide, and there is evidence that probiotics and prebiotics can have a positive influence against infective processes such as that due to RV. The aim of this study was to evidence a preventive role of one prebiotic mixture (of short-chain galactooligosaccharide/long-chain fructooligosaccharide), the probiotic Bifidobacterium breve M-16V and the combination of the prebiotic and the probiotic, as a synbiotic, in a suckling rat double-RV infection model. Hyperimmune bovine colostrum was used as protection control. The first infection was induced with RV SA11 and the second one with EDIM. Clinical variables and immune response were evaluated after both infections. Dietary interventions ameliorated clinical symptoms after the first infection. The prebiotic and the synbiotic significantly reduced viral shedding after the first infection, but all the interventions showed higher viral load than in the RV group after the second infection. All interventions modulated ex vivo antibody and cytokine production, gut wash cytokine levels and small intestine gene expression after both infections. In conclusion, a daily supplement of the products tested in this preclinical model is highly effective in preventing RV-induced diarrhea but allowing the boost of the early immune response for a future immune response against reinfection, suggesting that these components may be potential agents for modulating RV infection in infants. Keywords: prebiotic, probiotic, synbiotic, rotavirus, FOS, GOS, Bifidobacterium breve
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/130527
url https://hdl.handle.net/2445/130527
dc.language.none.fl_str_mv Inglés
Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2018.01318
Frontiers in Immunology, 2018, vol. 9, p. 1318
https://doi.org/10.3389/fimmu.2018.01318
dc.rights.none.fl_str_mv cc-by (c) Rigo-Adrover, Mar et al., 2018
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Rigo-Adrover, Mar et al., 2018
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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