Efficacy of antimicrobial agents delivered to hernia meshes using an adaptable thermo-responsive hyaluronic acid-based coating

19 p.

Bibliographic Details
Authors: Pérez Köhler, Bárbara|||0000-0002-5061-1526, Linardi, Flavio, Pascual González, María Gemma|||0000-0002-1623-4384, Bellón Caneiro, Juan Manuel|||0000-0002-6071-5011, Eglin, David, Guillaume, Olivier
Format: article
Publication Date:2020
Country:España
Institution:Universidad de Alcalá (UAH)
Repository:e_Buah Biblioteca Digital Universidad de Alcalá
Language:English
OAI Identifier:oai:ebuah.uah.es:10017/59786
Online Access:http://hdl.handle.net/10017/59786
https://dx.doi.org/10.1007/s10029-019-02096-3
Access Level:Open access
Keyword:Antibacterial
Coating
Hernia mesh
Hydrogel
Infection
Thermo-responsive
Medicina
Medicine
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spelling Efficacy of antimicrobial agents delivered to hernia meshes using an adaptable thermo-responsive hyaluronic acid-based coatingPérez Köhler, Bárbara|||0000-0002-5061-1526Linardi, FlavioPascual González, María Gemma|||0000-0002-1623-4384Bellón Caneiro, Juan Manuel|||0000-0002-6071-5011Eglin, DavidGuillaume, OlivierAntibacterialCoatingHernia meshHydrogelInfectionThermo-responsiveMedicinaMedicine19 p.Purpose Mesh-related infection is a critical outcome for patients with hernia defect stabilized with synthetic or biological meshes. Even though bioactive meshes loaded with antibiotics or antiseptics are slowly emerging in the market, the available solutions still lack versatility. Here, we proposed a polymer solution, i.e., hyaluronic acid-poly(N-isopropylacrylamide) (HApN), which forms a hydrogel to be used as coating for meshes only when it reaches body temperature. Methods We assessed how the gelation of HApN was influenced by the incorporation of different antibiotic and antiseptic formulations, and how this gel can be used to coat several mesh types. The impact of the coating on the elastic behavior of a macroporous mesh was tested under cyclic elongation condition. Finally, we selected two different coating formulations, one based on antibiotics (gentamicin + rifampicin) and one based on antiseptic (chlorhexidine) and tested in vitro their antimicrobial efficacies. Results HApN can be used as carrier for different antimicrobial agents, without having a strong influence on its gelation behavior. Porous or dense meshes can be coated with this polymer, even though the stability was not optimal on macroporous meshes such as Optilene when pores are too large. HApN loaded with drugs inhibited in vitro the growth of several Gram-positive and Gram-negative bacteria. Conclusion Compared to the available technologies developed to endow meshes with antibacterial activity, the proposed HApN offers further versatility with potential to prevent mesh-related infection in hernioplasty.European Hernia SocietyMinisterio de Ciencia, Innovación y Universidades20202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/59786https://dx.doi.org/10.1007/s10029-019-02096-3reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengNot available Not available Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/597862026-06-18T11:13:07Z
dc.title.none.fl_str_mv Efficacy of antimicrobial agents delivered to hernia meshes using an adaptable thermo-responsive hyaluronic acid-based coating
title Efficacy of antimicrobial agents delivered to hernia meshes using an adaptable thermo-responsive hyaluronic acid-based coating
spellingShingle Efficacy of antimicrobial agents delivered to hernia meshes using an adaptable thermo-responsive hyaluronic acid-based coating
Pérez Köhler, Bárbara|||0000-0002-5061-1526
Antibacterial
Coating
Hernia mesh
Hydrogel
Infection
Thermo-responsive
Medicina
Medicine
title_short Efficacy of antimicrobial agents delivered to hernia meshes using an adaptable thermo-responsive hyaluronic acid-based coating
title_full Efficacy of antimicrobial agents delivered to hernia meshes using an adaptable thermo-responsive hyaluronic acid-based coating
title_fullStr Efficacy of antimicrobial agents delivered to hernia meshes using an adaptable thermo-responsive hyaluronic acid-based coating
title_full_unstemmed Efficacy of antimicrobial agents delivered to hernia meshes using an adaptable thermo-responsive hyaluronic acid-based coating
title_sort Efficacy of antimicrobial agents delivered to hernia meshes using an adaptable thermo-responsive hyaluronic acid-based coating
dc.creator.none.fl_str_mv Pérez Köhler, Bárbara|||0000-0002-5061-1526
Linardi, Flavio
Pascual González, María Gemma|||0000-0002-1623-4384
Bellón Caneiro, Juan Manuel|||0000-0002-6071-5011
Eglin, David
Guillaume, Olivier
author Pérez Köhler, Bárbara|||0000-0002-5061-1526
author_facet Pérez Köhler, Bárbara|||0000-0002-5061-1526
Linardi, Flavio
Pascual González, María Gemma|||0000-0002-1623-4384
Bellón Caneiro, Juan Manuel|||0000-0002-6071-5011
Eglin, David
Guillaume, Olivier
author_role author
author2 Linardi, Flavio
Pascual González, María Gemma|||0000-0002-1623-4384
Bellón Caneiro, Juan Manuel|||0000-0002-6071-5011
Eglin, David
Guillaume, Olivier
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Antibacterial
Coating
Hernia mesh
Hydrogel
Infection
Thermo-responsive
Medicina
Medicine
topic Antibacterial
Coating
Hernia mesh
Hydrogel
Infection
Thermo-responsive
Medicina
Medicine
description 19 p.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/59786
https://dx.doi.org/10.1007/s10029-019-02096-3
url http://hdl.handle.net/10017/59786
https://dx.doi.org/10.1007/s10029-019-02096-3
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Not available Not available Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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