Association Between Smoking and Molecular Subtypes of Colorectal Cancer

Wang, Xiaoliang; Amitay, Efrat L.; Harrison, Tabitha A.; Banbury, Barbara L.; Berndt, Sonja I.; Brenner, Hermann; Buchanan, Daniel D.; Campbell, Peter T.; Cao, Yin; Chan, Andrew T.; Chang-Claude, Jenny; Gallinger, Steven; Giannakis, Marios; Giles, Graham G.; Gunter, Marc J.; Hopper, John L.; Jenkins, Mark A.; Lin, Yi; Moreno Aguado, Víctor; Nishihara, Reiko; Newcomb, Polly A.; Ogino, Shuji; Phipps, Amanda I.; Sakoda, Lori C.; Schoen, Robert E.; Slattery, Martha L.; Song, Mingyang; Sun, Wei; Thibodeau, Steven N.; Toland, Amanda E.; Guelpen, Bethany van; Woods, Michael O.; Hsu, Li; Hoffmeister, Michael; Peters, Ulrike

Association Between Smoking and Molecular Subtypes of Colorectal Cancer

Background: Smoking is associated with colorectal cancer (CRC) risk. Previous studies suggested this association may be restricted to certain molecular subtypes of CRC, but large-scale comprehensive analysis is lacking. Methods: A total of 9789 CRC cases and 11 231 controls of European ancestry from...

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Autores:	Wang, Xiaoliang, Amitay, Efrat L., Harrison, Tabitha A., Banbury, Barbara L., Berndt, Sonja I., Brenner, Hermann, Buchanan, Daniel D., Campbell, Peter T., Cao, Yin, Chan, Andrew T., Chang-Claude, Jenny, Gallinger, Steven, Giannakis, Marios, Giles, Graham G., Gunter, Marc J., Hopper, John L., Jenkins, Mark A., Lin, Yi, Moreno Aguado, Víctor, Nishihara, Reiko, Newcomb, Polly A., Ogino, Shuji, Phipps, Amanda I., Sakoda, Lori C., Schoen, Robert E., Slattery, Martha L., Song, Mingyang, Sun, Wei, Thibodeau, Steven N., Toland, Amanda E., Guelpen, Bethany van, Woods, Michael O., Hsu, Li, Hoffmeister, Michael, Peters, Ulrike
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2021
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/182942
Acceso en línea:	https://hdl.handle.net/2445/182942
Access Level:	acceso abierto
Palabra clave:	Hàbit de fumar Càncer colorectal Smoking Colorectal cancer

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spelling	Association Between Smoking and Molecular Subtypes of Colorectal CancerWang, XiaoliangAmitay, Efrat L.Harrison, Tabitha A.Banbury, Barbara L.Berndt, Sonja I.Brenner, HermannBuchanan, Daniel D.Campbell, Peter T.Cao, YinChan, Andrew T.Chang-Claude, JennyGallinger, StevenGiannakis, MariosGiles, Graham G.Gunter, Marc J.Hopper, John L.Jenkins, Mark A.Lin, YiMoreno Aguado, VíctorNishihara, ReikoNewcomb, Polly A.Ogino, ShujiPhipps, Amanda I.Sakoda, Lori C.Schoen, Robert E.Slattery, Martha L.Song, MingyangSun, WeiThibodeau, Steven N.Toland, Amanda E.Guelpen, Bethany vanWoods, Michael O.Hsu, LiHoffmeister, MichaelPeters, UlrikeHàbit de fumarCàncer colorectalSmokingColorectal cancerBackground: Smoking is associated with colorectal cancer (CRC) risk. Previous studies suggested this association may be restricted to certain molecular subtypes of CRC, but large-scale comprehensive analysis is lacking. Methods: A total of 9789 CRC cases and 11 231 controls of European ancestry from 11 observational studies were included. We harmonized smoking variables across studies and derived sex study-specific quartiles of pack-years of smoking for analysis. Four somatic colorectal tumor markers were assessed individually and in combination, including BRAF mutation, KRAS mutation, CpG island methylator phenotype (CIMP), and microsatellite instability (MSI) status. A multinomial logistic regression analysis was used to assess the association between smoking and risk of CRC subtypes by molecular characteristics, adjusting for age, sex, and study. All statistical tests were 2-sided and adjusted for Bonferroni correction. Results: Heavier smoking was associated with higher risk of CRC overall and stratified by individual markers (P-trend <.001). The associations differed statistically significantly between all molecular subtypes, which was the most statistically significant for CIMP and BRAF. Compared with never-smokers, smokers in the fourth quartile of pack-years had a 90% higher risk of CIMP-positive CRC (odds ratio = 1.90, 95% confidence interval = 1.60 to 2.26) but only 35% higher risk for CIMP-negative CRC (odds ratio = 1.35, 95% confidence interval = 1.22 to 1.49; P-difference = 2.1 x 10(-6)). The association was also stronger in tumors that were CIMP positive, MSI high, or KRAS wild type when combined (P-difference <.001). Conclusion: Smoking was associated with differential risk of CRC subtypes defined by molecular characteristics. Heavier smokers had particularly higher risk of CRC subtypes that were CIMP positive and MSI high in combination, suggesting that smoking may be involved in the development of colorectal tumors via the serrated pathway.Oxford University Press (OUP)2022202220212022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/182942Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1093/jncics/pkab056JNCI Cancer Spectrum, 2021https://doi.org/10.1093/jncics/pkab056cc by (c) Wang, Xiaoliang et al, 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1829422026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Association Between Smoking and Molecular Subtypes of Colorectal Cancer
title	Association Between Smoking and Molecular Subtypes of Colorectal Cancer
spellingShingle	Association Between Smoking and Molecular Subtypes of Colorectal Cancer Wang, Xiaoliang Hàbit de fumar Càncer colorectal Smoking Colorectal cancer
title_short	Association Between Smoking and Molecular Subtypes of Colorectal Cancer
title_full	Association Between Smoking and Molecular Subtypes of Colorectal Cancer
title_fullStr	Association Between Smoking and Molecular Subtypes of Colorectal Cancer
title_full_unstemmed	Association Between Smoking and Molecular Subtypes of Colorectal Cancer
title_sort	Association Between Smoking and Molecular Subtypes of Colorectal Cancer
dc.creator.none.fl_str_mv	Wang, Xiaoliang Amitay, Efrat L. Harrison, Tabitha A. Banbury, Barbara L. Berndt, Sonja I. Brenner, Hermann Buchanan, Daniel D. Campbell, Peter T. Cao, Yin Chan, Andrew T. Chang-Claude, Jenny Gallinger, Steven Giannakis, Marios Giles, Graham G. Gunter, Marc J. Hopper, John L. Jenkins, Mark A. Lin, Yi Moreno Aguado, Víctor Nishihara, Reiko Newcomb, Polly A. Ogino, Shuji Phipps, Amanda I. Sakoda, Lori C. Schoen, Robert E. Slattery, Martha L. Song, Mingyang Sun, Wei Thibodeau, Steven N. Toland, Amanda E. Guelpen, Bethany van Woods, Michael O. Hsu, Li Hoffmeister, Michael Peters, Ulrike
author	Wang, Xiaoliang
author_facet	Wang, Xiaoliang Amitay, Efrat L. Harrison, Tabitha A. Banbury, Barbara L. Berndt, Sonja I. Brenner, Hermann Buchanan, Daniel D. Campbell, Peter T. Cao, Yin Chan, Andrew T. Chang-Claude, Jenny Gallinger, Steven Giannakis, Marios Giles, Graham G. Gunter, Marc J. Hopper, John L. Jenkins, Mark A. Lin, Yi Moreno Aguado, Víctor Nishihara, Reiko Newcomb, Polly A. Ogino, Shuji Phipps, Amanda I. Sakoda, Lori C. Schoen, Robert E. Slattery, Martha L. Song, Mingyang Sun, Wei Thibodeau, Steven N. Toland, Amanda E. Guelpen, Bethany van Woods, Michael O. Hsu, Li Hoffmeister, Michael Peters, Ulrike
author_role	author
author2	Amitay, Efrat L. Harrison, Tabitha A. Banbury, Barbara L. Berndt, Sonja I. Brenner, Hermann Buchanan, Daniel D. Campbell, Peter T. Cao, Yin Chan, Andrew T. Chang-Claude, Jenny Gallinger, Steven Giannakis, Marios Giles, Graham G. Gunter, Marc J. Hopper, John L. Jenkins, Mark A. Lin, Yi Moreno Aguado, Víctor Nishihara, Reiko Newcomb, Polly A. Ogino, Shuji Phipps, Amanda I. Sakoda, Lori C. Schoen, Robert E. Slattery, Martha L. Song, Mingyang Sun, Wei Thibodeau, Steven N. Toland, Amanda E. Guelpen, Bethany van Woods, Michael O. Hsu, Li Hoffmeister, Michael Peters, Ulrike
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Hàbit de fumar Càncer colorectal Smoking Colorectal cancer
topic	Hàbit de fumar Càncer colorectal Smoking Colorectal cancer
description	Background: Smoking is associated with colorectal cancer (CRC) risk. Previous studies suggested this association may be restricted to certain molecular subtypes of CRC, but large-scale comprehensive analysis is lacking. Methods: A total of 9789 CRC cases and 11 231 controls of European ancestry from 11 observational studies were included. We harmonized smoking variables across studies and derived sex study-specific quartiles of pack-years of smoking for analysis. Four somatic colorectal tumor markers were assessed individually and in combination, including BRAF mutation, KRAS mutation, CpG island methylator phenotype (CIMP), and microsatellite instability (MSI) status. A multinomial logistic regression analysis was used to assess the association between smoking and risk of CRC subtypes by molecular characteristics, adjusting for age, sex, and study. All statistical tests were 2-sided and adjusted for Bonferroni correction. Results: Heavier smoking was associated with higher risk of CRC overall and stratified by individual markers (P-trend <.001). The associations differed statistically significantly between all molecular subtypes, which was the most statistically significant for CIMP and BRAF. Compared with never-smokers, smokers in the fourth quartile of pack-years had a 90% higher risk of CIMP-positive CRC (odds ratio = 1.90, 95% confidence interval = 1.60 to 2.26) but only 35% higher risk for CIMP-negative CRC (odds ratio = 1.35, 95% confidence interval = 1.22 to 1.49; P-difference = 2.1 x 10(-6)). The association was also stronger in tumors that were CIMP positive, MSI high, or KRAS wild type when combined (P-difference <.001). Conclusion: Smoking was associated with differential risk of CRC subtypes defined by molecular characteristics. Heavier smokers had particularly higher risk of CRC subtypes that were CIMP positive and MSI high in combination, suggesting that smoking may be involved in the development of colorectal tumors via the serrated pathway.
publishDate	2021
dc.date.none.fl_str_mv	2021 2022 2022 2022
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/182942
url	https://hdl.handle.net/2445/182942
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1093/jncics/pkab056 JNCI Cancer Spectrum, 2021 https://doi.org/10.1093/jncics/pkab056
dc.rights.none.fl_str_mv	cc by (c) Wang, Xiaoliang et al, 2021 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc by (c) Wang, Xiaoliang et al, 2021 http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	10 p. application/pdf
dc.publisher.none.fl_str_mv	Oxford University Press (OUP)
publisher.none.fl_str_mv	Oxford University Press (OUP)
dc.source.none.fl_str_mv	Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Association Between Smoking and Molecular Subtypes of Colorectal Cancer

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