Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?

Hyperphagia is one of the main problems of patients with Prader-Willi syndrome (PWS) to cope with everyday life. The underlying mechanisms are not yet well understood. Gut-brain hormones are an interrelated network that may be at least partially involved. We aimed to study the hormonal profile of PW...

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Autores: Bueno Díez, Marta, Boixadera-Planas, Ester, Blanco-Hinojo, Laura, Esteba-Castillo, Susanna, Giménez-Palop, Olga, Torrents-Rodas, David, Pujol, Jesús, Corripio, Raquel, Deus, Joan, Caixàs, Assumpta
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/84095
Acceso en línea:https://doi.org/10.3390/jcm10215170
http://hdl.handle.net/10459.1/84095
Access Level:acceso abierto
Palabra clave:Prader-Willi syndrome
obesity
hunger
satiety
Prader-Willi, Síndrome de
Obesitat
Fam
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repository_id_str
spelling Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?Bueno Díez, MartaBoixadera-Planas, EsterBlanco-Hinojo, LauraEsteba-Castillo, SusannaGiménez-Palop, OlgaTorrents-Rodas, DavidPujol, JesúsCorripio, RaquelDeus, JoanCaixàs, AssumptaPrader-Willi syndromeobesityhungersatietyPrader-Willi, Síndrome deObesitatFamHyperphagia is one of the main problems of patients with Prader-Willi syndrome (PWS) to cope with everyday life. The underlying mechanisms are not yet well understood. Gut-brain hormones are an interrelated network that may be at least partially involved. We aimed to study the hormonal profile of PWS patients in comparison with obese and healthy controls. Thirty adult PWS patients (15 men; age 27.5 ± 8.02 years; BMI 32.4 ± 8.14 kg/m2 ), 30 obese and 30 healthy controls were studied before and after eating a hypercaloric liquid diet. Plasma brain-derived neurotrophic factor (BDNF), leptin, total and active ghrelin, peptide YY (PYY), pancreatic polypeptide (PP), Glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and amylin were determined at times 00 , 300 , 600 and 1200 . Cluster analysis was used. When considering all peptides together, two clusters were established according to fasting hormonal standardized concentrations. Cluster 1 encompassed most of obese (25/30) and healthy controls (28/30). By contrast, the majority of patients with PWS were located in Cluster 2 (23/27) and presented a similar fasting profile with hyperghrelinemia, high levels of leptin, PYY, GIP and GLP-1, compared to Cluster 1; that may reflect a dysfunction of these hunger/satiety hormones. When peptide behavior over the time was considered, PP concentrations were not sustained postprandially from 60 min onwards in Cluster 2. BDNF and amylin did not help to differentiate the two clusters. Thus, cluster analysis could be a good tool to distinguish and characterize the differences in hormone responses between PWS and obese or healthy controls.We thank the Associació Catalana de Síndrome de Prader–Willi and all the subjects and their families for kindly agreeing to participate. The Agency of University and Research Funding Management of the Catalonia Government participated in the context of Research Groups SGR2017/1198 and SGR2017/923.MDPI202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3390/jcm10215170http://hdl.handle.net/10459.1/84095http://hdl.handle.net/10459.1/84095reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.3390/jcm10215170Journal of Clinical Medicine, 2021, núm. 10, 5170cc-by (c) Marta Bueno et.al., 2021info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/840952026-05-29T05:05:01Z
dc.title.none.fl_str_mv Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?
title Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?
spellingShingle Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?
Bueno Díez, Marta
Prader-Willi syndrome
obesity
hunger
satiety
Prader-Willi, Síndrome de
Obesitat
Fam
title_short Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?
title_full Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?
title_fullStr Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?
title_full_unstemmed Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?
title_sort Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?
dc.creator.none.fl_str_mv Bueno Díez, Marta
Boixadera-Planas, Ester
Blanco-Hinojo, Laura
Esteba-Castillo, Susanna
Giménez-Palop, Olga
Torrents-Rodas, David
Pujol, Jesús
Corripio, Raquel
Deus, Joan
Caixàs, Assumpta
author Bueno Díez, Marta
author_facet Bueno Díez, Marta
Boixadera-Planas, Ester
Blanco-Hinojo, Laura
Esteba-Castillo, Susanna
Giménez-Palop, Olga
Torrents-Rodas, David
Pujol, Jesús
Corripio, Raquel
Deus, Joan
Caixàs, Assumpta
author_role author
author2 Boixadera-Planas, Ester
Blanco-Hinojo, Laura
Esteba-Castillo, Susanna
Giménez-Palop, Olga
Torrents-Rodas, David
Pujol, Jesús
Corripio, Raquel
Deus, Joan
Caixàs, Assumpta
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Prader-Willi syndrome
obesity
hunger
satiety
Prader-Willi, Síndrome de
Obesitat
Fam
topic Prader-Willi syndrome
obesity
hunger
satiety
Prader-Willi, Síndrome de
Obesitat
Fam
description Hyperphagia is one of the main problems of patients with Prader-Willi syndrome (PWS) to cope with everyday life. The underlying mechanisms are not yet well understood. Gut-brain hormones are an interrelated network that may be at least partially involved. We aimed to study the hormonal profile of PWS patients in comparison with obese and healthy controls. Thirty adult PWS patients (15 men; age 27.5 ± 8.02 years; BMI 32.4 ± 8.14 kg/m2 ), 30 obese and 30 healthy controls were studied before and after eating a hypercaloric liquid diet. Plasma brain-derived neurotrophic factor (BDNF), leptin, total and active ghrelin, peptide YY (PYY), pancreatic polypeptide (PP), Glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and amylin were determined at times 00 , 300 , 600 and 1200 . Cluster analysis was used. When considering all peptides together, two clusters were established according to fasting hormonal standardized concentrations. Cluster 1 encompassed most of obese (25/30) and healthy controls (28/30). By contrast, the majority of patients with PWS were located in Cluster 2 (23/27) and presented a similar fasting profile with hyperghrelinemia, high levels of leptin, PYY, GIP and GLP-1, compared to Cluster 1; that may reflect a dysfunction of these hunger/satiety hormones. When peptide behavior over the time was considered, PP concentrations were not sustained postprandially from 60 min onwards in Cluster 2. BDNF and amylin did not help to differentiate the two clusters. Thus, cluster analysis could be a good tool to distinguish and characterize the differences in hormone responses between PWS and obese or healthy controls.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/jcm10215170
http://hdl.handle.net/10459.1/84095
http://hdl.handle.net/10459.1/84095
url https://doi.org/10.3390/jcm10215170
http://hdl.handle.net/10459.1/84095
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.3390/jcm10215170
Journal of Clinical Medicine, 2021, núm. 10, 5170
dc.rights.none.fl_str_mv cc-by (c) Marta Bueno et.al., 2021
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Marta Bueno et.al., 2021
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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