Nerve growth factor precursor alterations in neuron-derived extracellular vesicles from individuals with Down syndrome along the Alzheimer's disease continuum

[Background] In Down syndrome (DS) and Alzheimer's disease (AD), nerve growth factor precursor protein (proNGF) accumulates in the brain. However, its non-invasive detection using neuron-derived extracellular vesicles (NDEVs) from plasma remains unexplored

Detalles Bibliográficos
Autores: Valle Tamayo, Natalia, Aranha, Mateus, Pérez-González, Rocío, Serrano-Requena, Sara, Videla, Laura, Barroeta, Isabel, Benejam, Bessy, Chiva-Blanch, Gemma, Jiménez, Amanda, Busciglio, Jorge, Wisniewski, Thomas, Do Carmo, Sonia, Álvarez-Sánchez, Esther, Muñoz, Laia, Bejanin, Alexandre, Belbin, Olivia, Alcolea, Daniel, Carmona-Iragui, María, Lleó, Alberto, Cuello, A. Claudio, Fortea, Juan, Dols-Icardo, Oriol, Iulita, M. Florencia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/392515
Acceso en línea:http://hdl.handle.net/10261/392515
https://api.elsevier.com/content/abstract/scopus_id/105003795006
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Down syndrome
Nerve growth factor precursor protein
Neuronal injury
Neuron‐derived extracellular vesicle
Tau pathology
Descripción
Sumario:[Background] In Down syndrome (DS) and Alzheimer's disease (AD), nerve growth factor precursor protein (proNGF) accumulates in the brain. However, its non-invasive detection using neuron-derived extracellular vesicles (NDEVs) from plasma remains unexplored

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