The Zebrafish Embryo as a Model to Test Protective Effects of Food Antioxidant Compounds

t: The antioxidant activity of food compounds is one of the properties generating the most interest, due to its health benefits and correlation with the prevention of chronic disease. This activity is usually measured using in vitro assays, which cannot predict in vivo effects or mechanisms of actio...

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Autores: Arteaga, Cristina, Boix Sabrià, Núria, Teixidó Condomines, Elisabet, Marizande, Fernanda, Cadena, Santiago, Bustillos Ortiz, Alcides Alberto
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/183152
Acesso em linha:https://hdl.handle.net/2445/183152
Access Level:acceso abierto
Palavra-chave:Peix zebra
Polifenols
Antioxidants
Zebra danio
Polyphenols
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spelling The Zebrafish Embryo as a Model to Test Protective Effects of Food Antioxidant CompoundsArteaga, CristinaBoix Sabrià, NúriaTeixidó Condomines, ElisabetMarizande, FernandaCadena, SantiagoBustillos Ortiz, Alcides AlbertoPeix zebraPolifenolsAntioxidantsZebra danioPolyphenolsAntioxidantst: The antioxidant activity of food compounds is one of the properties generating the most interest, due to its health benefits and correlation with the prevention of chronic disease. This activity is usually measured using in vitro assays, which cannot predict in vivo effects or mechanisms of action. The objective of this study was to evaluate the in vivo protective effects of six phenolic compounds (naringenin, apigenin, rutin, oleuropein, chlorogenic acid, and curcumin) and three carotenoids (lycopene B, β-carotene, and astaxanthin) naturally present in foods using a zebrafish embryo model. The zebrafish embryo was pretreated with each of the nine antioxidant compounds and then exposed to tert-butyl hydroperoxide (tBOOH), a known inducer of oxidative stress in zebrafish. Significant differences were determined by comparing the concentration-response of the tBOOH induced lethality and dysmorphogenesis against the pretreated embryos with the antioxidant compounds. A protective effect of each compound, except β-carotene, against oxidative-stressinduced lethality was found. Furthermore, apigenin, rutin, and curcumin also showed protective effects against dysmorphogenesis. On the other hand, β-carotene exhibited increased lethality and dysmorphogenesis compared to the tBOOH treatment alone.MDPI2022202220212022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/183152Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/molecules26195786Molecules, 2021, vol. 26, num. 19, p. 1-11https://doi.org/10.3390/molecules26195786cc-by (c) Arteaga, Cristina et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1831522026-05-29T05:05:01Z
dc.title.none.fl_str_mv The Zebrafish Embryo as a Model to Test Protective Effects of Food Antioxidant Compounds
title The Zebrafish Embryo as a Model to Test Protective Effects of Food Antioxidant Compounds
spellingShingle The Zebrafish Embryo as a Model to Test Protective Effects of Food Antioxidant Compounds
Arteaga, Cristina
Peix zebra
Polifenols
Antioxidants
Zebra danio
Polyphenols
Antioxidants
title_short The Zebrafish Embryo as a Model to Test Protective Effects of Food Antioxidant Compounds
title_full The Zebrafish Embryo as a Model to Test Protective Effects of Food Antioxidant Compounds
title_fullStr The Zebrafish Embryo as a Model to Test Protective Effects of Food Antioxidant Compounds
title_full_unstemmed The Zebrafish Embryo as a Model to Test Protective Effects of Food Antioxidant Compounds
title_sort The Zebrafish Embryo as a Model to Test Protective Effects of Food Antioxidant Compounds
dc.creator.none.fl_str_mv Arteaga, Cristina
Boix Sabrià, Núria
Teixidó Condomines, Elisabet
Marizande, Fernanda
Cadena, Santiago
Bustillos Ortiz, Alcides Alberto
author Arteaga, Cristina
author_facet Arteaga, Cristina
Boix Sabrià, Núria
Teixidó Condomines, Elisabet
Marizande, Fernanda
Cadena, Santiago
Bustillos Ortiz, Alcides Alberto
author_role author
author2 Boix Sabrià, Núria
Teixidó Condomines, Elisabet
Marizande, Fernanda
Cadena, Santiago
Bustillos Ortiz, Alcides Alberto
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Peix zebra
Polifenols
Antioxidants
Zebra danio
Polyphenols
Antioxidants
topic Peix zebra
Polifenols
Antioxidants
Zebra danio
Polyphenols
Antioxidants
description t: The antioxidant activity of food compounds is one of the properties generating the most interest, due to its health benefits and correlation with the prevention of chronic disease. This activity is usually measured using in vitro assays, which cannot predict in vivo effects or mechanisms of action. The objective of this study was to evaluate the in vivo protective effects of six phenolic compounds (naringenin, apigenin, rutin, oleuropein, chlorogenic acid, and curcumin) and three carotenoids (lycopene B, β-carotene, and astaxanthin) naturally present in foods using a zebrafish embryo model. The zebrafish embryo was pretreated with each of the nine antioxidant compounds and then exposed to tert-butyl hydroperoxide (tBOOH), a known inducer of oxidative stress in zebrafish. Significant differences were determined by comparing the concentration-response of the tBOOH induced lethality and dysmorphogenesis against the pretreated embryos with the antioxidant compounds. A protective effect of each compound, except β-carotene, against oxidative-stressinduced lethality was found. Furthermore, apigenin, rutin, and curcumin also showed protective effects against dysmorphogenesis. On the other hand, β-carotene exhibited increased lethality and dysmorphogenesis compared to the tBOOH treatment alone.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183152
url https://hdl.handle.net/2445/183152
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/molecules26195786
Molecules, 2021, vol. 26, num. 19, p. 1-11
https://doi.org/10.3390/molecules26195786
dc.rights.none.fl_str_mv cc-by (c) Arteaga, Cristina et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Arteaga, Cristina et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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