Augmented renal clearance. An unnoticed relevant event
Augmented renal clearance (ARC) is a phenomenon that can lead to a therapeutic failure of those drugs of renal clearance. The purpose of the study was to ascertain the prevalence of ARC in the critically ill patient, to study the glomerular filtration rate (GFR) throughout the follow-up and analyze...
| Autores: | , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:272013 |
| Acceso en línea: | https://ddd.uab.cat/record/272013 https://dx.doi.org/urn:doi:10.1177/00368504211018580 |
| Access Level: | acceso abierto |
| Palabra clave: | Augmented renal clearance ARC Glomerular filtrate rate GFR Chronic Kidney Disease Epidemiology Collaboration formula CKD-EPI Critically ill patient Prevalence |
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Augmented renal clearance. An unnoticed relevant eventTomasa-Irriguible, Teresa Maria|||0000-0001-8033-8527Sabater-Riera, Joan|||0000-0003-1246-5537Pérez-Carrasco, Marcos|||0000-0001-7086-083XOrtiz-Ballujera, PatriciaDíaz Buendia, Yolanda|||0000-0001-8221-7876Navas Pérez, Ana Maria|||0000-0002-2860-4864Betbesé Roig, Antoni Jordi|||0000-0002-9059-4046Rodríguez-López, MiguelIbarz, Mercedes|||0000-0003-2908-0748Olmo-Isasmendi, AitorOliva-Zelaya, IbanRovira-Anglès, ConxitaCano Hernández, Silvia|||0000-0002-9487-6673Vendrell-Torra, Ester|||0000-0002-3967-8105Catalan-Ibars, Rosa-María|||0000-0002-9455-1772Miralbés-Torner, MarGonzález de Molina, Francisco Javier|||0000-0002-2059-3400Xirgú, JudithMarcos Neira, PilarAugmented renal clearanceARCGlomerular filtrate rateGFRChronic Kidney Disease Epidemiology Collaboration formulaCKD-EPICritically ill patientPrevalenceAugmented renal clearance (ARC) is a phenomenon that can lead to a therapeutic failure of those drugs of renal clearance. The purpose of the study was to ascertain the prevalence of ARC in the critically ill patient, to study the glomerular filtration rate (GFR) throughout the follow-up and analyze the concordance between the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimation formula and measured GFR. Observational, prospective, multicenter study. ARC was defined as a creatinine clearance greater than 130 ml/min/1.73 m. Eighteen hospitals were recruited. GFR measurements carried out twice weekly during a 2-month follow-up period. A total of 561 patients were included. ARC was found to have a non-negligible prevalence of 30%. More even, up to 10.7% already had ARC at intensive care unit (ICU) admission. No specific pattern of GFR was found during the follow-up. Patients in the ARC group were younger 56.5 (53.5-58.5) versus 66 (63.5-68.5) years than in the non-ARC group, p < 0.001. ICU mortality was lower in the ARC group, 6.9% versus 14.5%, p = 0.003. There was no concordance between the estimation of GFR by the CKD-EPI formula and GFR calculated from the 4-h urine. ARC is found in up to 30% of ICU patients, so renal removal drugs could be under dosed by up to 30%. And ARC is already detected on admission in 10%. It is a dynamic phenomenon without an established pattern that usually occurs in younger patients that can last for several weeks. And the CKD-EPI formula does not work to estimate the real creatinine clearance of these patients. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/272013https://dx.doi.org/urn:doi:10.1177/00368504211018580reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2720132026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Augmented renal clearance. An unnoticed relevant event |
| title |
Augmented renal clearance. An unnoticed relevant event |
| spellingShingle |
Augmented renal clearance. An unnoticed relevant event Tomasa-Irriguible, Teresa Maria|||0000-0001-8033-8527 Augmented renal clearance ARC Glomerular filtrate rate GFR Chronic Kidney Disease Epidemiology Collaboration formula CKD-EPI Critically ill patient Prevalence |
| title_short |
Augmented renal clearance. An unnoticed relevant event |
| title_full |
Augmented renal clearance. An unnoticed relevant event |
| title_fullStr |
Augmented renal clearance. An unnoticed relevant event |
| title_full_unstemmed |
Augmented renal clearance. An unnoticed relevant event |
| title_sort |
Augmented renal clearance. An unnoticed relevant event |
| dc.creator.none.fl_str_mv |
Tomasa-Irriguible, Teresa Maria|||0000-0001-8033-8527 Sabater-Riera, Joan|||0000-0003-1246-5537 Pérez-Carrasco, Marcos|||0000-0001-7086-083X Ortiz-Ballujera, Patricia Díaz Buendia, Yolanda|||0000-0001-8221-7876 Navas Pérez, Ana Maria|||0000-0002-2860-4864 Betbesé Roig, Antoni Jordi|||0000-0002-9059-4046 Rodríguez-López, Miguel Ibarz, Mercedes|||0000-0003-2908-0748 Olmo-Isasmendi, Aitor Oliva-Zelaya, Iban Rovira-Anglès, Conxita Cano Hernández, Silvia|||0000-0002-9487-6673 Vendrell-Torra, Ester|||0000-0002-3967-8105 Catalan-Ibars, Rosa-María|||0000-0002-9455-1772 Miralbés-Torner, Mar González de Molina, Francisco Javier|||0000-0002-2059-3400 Xirgú, Judith Marcos Neira, Pilar |
| author |
Tomasa-Irriguible, Teresa Maria|||0000-0001-8033-8527 |
| author_facet |
Tomasa-Irriguible, Teresa Maria|||0000-0001-8033-8527 Sabater-Riera, Joan|||0000-0003-1246-5537 Pérez-Carrasco, Marcos|||0000-0001-7086-083X Ortiz-Ballujera, Patricia Díaz Buendia, Yolanda|||0000-0001-8221-7876 Navas Pérez, Ana Maria|||0000-0002-2860-4864 Betbesé Roig, Antoni Jordi|||0000-0002-9059-4046 Rodríguez-López, Miguel Ibarz, Mercedes|||0000-0003-2908-0748 Olmo-Isasmendi, Aitor Oliva-Zelaya, Iban Rovira-Anglès, Conxita Cano Hernández, Silvia|||0000-0002-9487-6673 Vendrell-Torra, Ester|||0000-0002-3967-8105 Catalan-Ibars, Rosa-María|||0000-0002-9455-1772 Miralbés-Torner, Mar González de Molina, Francisco Javier|||0000-0002-2059-3400 Xirgú, Judith Marcos Neira, Pilar |
| author_role |
author |
| author2 |
Sabater-Riera, Joan|||0000-0003-1246-5537 Pérez-Carrasco, Marcos|||0000-0001-7086-083X Ortiz-Ballujera, Patricia Díaz Buendia, Yolanda|||0000-0001-8221-7876 Navas Pérez, Ana Maria|||0000-0002-2860-4864 Betbesé Roig, Antoni Jordi|||0000-0002-9059-4046 Rodríguez-López, Miguel Ibarz, Mercedes|||0000-0003-2908-0748 Olmo-Isasmendi, Aitor Oliva-Zelaya, Iban Rovira-Anglès, Conxita Cano Hernández, Silvia|||0000-0002-9487-6673 Vendrell-Torra, Ester|||0000-0002-3967-8105 Catalan-Ibars, Rosa-María|||0000-0002-9455-1772 Miralbés-Torner, Mar González de Molina, Francisco Javier|||0000-0002-2059-3400 Xirgú, Judith Marcos Neira, Pilar |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Augmented renal clearance ARC Glomerular filtrate rate GFR Chronic Kidney Disease Epidemiology Collaboration formula CKD-EPI Critically ill patient Prevalence |
| topic |
Augmented renal clearance ARC Glomerular filtrate rate GFR Chronic Kidney Disease Epidemiology Collaboration formula CKD-EPI Critically ill patient Prevalence |
| description |
Augmented renal clearance (ARC) is a phenomenon that can lead to a therapeutic failure of those drugs of renal clearance. The purpose of the study was to ascertain the prevalence of ARC in the critically ill patient, to study the glomerular filtration rate (GFR) throughout the follow-up and analyze the concordance between the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimation formula and measured GFR. Observational, prospective, multicenter study. ARC was defined as a creatinine clearance greater than 130 ml/min/1.73 m. Eighteen hospitals were recruited. GFR measurements carried out twice weekly during a 2-month follow-up period. A total of 561 patients were included. ARC was found to have a non-negligible prevalence of 30%. More even, up to 10.7% already had ARC at intensive care unit (ICU) admission. No specific pattern of GFR was found during the follow-up. Patients in the ARC group were younger 56.5 (53.5-58.5) versus 66 (63.5-68.5) years than in the non-ARC group, p < 0.001. ICU mortality was lower in the ARC group, 6.9% versus 14.5%, p = 0.003. There was no concordance between the estimation of GFR by the CKD-EPI formula and GFR calculated from the 4-h urine. ARC is found in up to 30% of ICU patients, so renal removal drugs could be under dosed by up to 30%. And ARC is already detected on admission in 10%. It is a dynamic phenomenon without an established pattern that usually occurs in younger patients that can last for several weeks. And the CKD-EPI formula does not work to estimate the real creatinine clearance of these patients. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/272013 https://dx.doi.org/urn:doi:10.1177/00368504211018580 |
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https://ddd.uab.cat/record/272013 https://dx.doi.org/urn:doi:10.1177/00368504211018580 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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