In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies

The implantation of oligodendrocyte precursor cells may be a useful therapeutic strategy for targeting remyelination. However, it is yet to be established how these cells behave after implantation and whether they retain the capacity to proliferate or differentiate into myelin-forming oligodendrocyt...

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Autores: Gómez Pinedo, Ulises, Matias-Guiu Antem, Jordi, Ojeda Hernández, Doddy Denise, Fuente Martín, Sarah De La, Mohammed-Fathy Kamal, Ola, Benito Martín, María Soledad, Selma Calvo, Belén, Montero Escribano, Paloma, Matías-Guiu Guía, Jorge
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/104914
Acceso en línea:https://hdl.handle.net/20.500.14352/104914
Access Level:acceso abierto
Palabra clave:61
Multiple sclerosis
HOG cells
oligodendrocyte precursor cells
oligodendrocytes
corticosteroids
demyelination
remyelination
Ciencias Biomédicas
32 Ciencias Médicas
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spelling In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell TherapiesGómez Pinedo, UlisesMatias-Guiu Antem, JordiOjeda Hernández, Doddy DeniseFuente Martín, Sarah De LaMohammed-Fathy Kamal, OlaBenito Martín, María SoledadSelma Calvo, BelénMontero Escribano, PalomaMatías-Guiu Guía, Jorge61Multiple sclerosisHOG cellsoligodendrocyte precursor cellsoligodendrocytescorticosteroidsdemyelinationremyelinationCiencias Biomédicas32 Ciencias MédicasThe implantation of oligodendrocyte precursor cells may be a useful therapeutic strategy for targeting remyelination. However, it is yet to be established how these cells behave after implantation and whether they retain the capacity to proliferate or differentiate into myelin-forming oligodendrocytes. One essential issue is the creation of administration protocols and determining which factors need to be well established. There is controversy around whether these cells may be implanted simultaneously with corticosteroid treatment, which is widely used in many clinical situations. This study assesses the influence of corticosteroids on the capacity for proliferation and differentiation and the survival of human oligodendroglioma cells. Our findings show that corticosteroids reduce the capacity of these cells to proliferate and to differentiate into oligodendrocytes and decrease cell survival. Thus, their effect does not favour remyelination; this is consistent with the results of studies with rodent cells. In conclusion, protocols for the administration of oligodendrocyte lineage cells with the aim of repopulating oligodendroglial niches or repairing demyelinated axons should not include corticosteroids, given the evidence that the effects of these drugs may undermine the objectives of cell transplantation.MDPIUniversidad Complutense de Madrid20232023-01-0120232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/104914reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengAES ISCIII PI21open accesshttp://purl.org/coar/access_right/c_abf2ATTRIBUTION 4.0 INTERNATIONALhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1049142026-06-02T12:44:21Z
dc.title.none.fl_str_mv In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies
title In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies
spellingShingle In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies
Gómez Pinedo, Ulises
61
Multiple sclerosis
HOG cells
oligodendrocyte precursor cells
oligodendrocytes
corticosteroids
demyelination
remyelination
Ciencias Biomédicas
32 Ciencias Médicas
title_short In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies
title_full In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies
title_fullStr In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies
title_full_unstemmed In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies
title_sort In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies
dc.creator.none.fl_str_mv Gómez Pinedo, Ulises
Matias-Guiu Antem, Jordi
Ojeda Hernández, Doddy Denise
Fuente Martín, Sarah De La
Mohammed-Fathy Kamal, Ola
Benito Martín, María Soledad
Selma Calvo, Belén
Montero Escribano, Paloma
Matías-Guiu Guía, Jorge
author Gómez Pinedo, Ulises
author_facet Gómez Pinedo, Ulises
Matias-Guiu Antem, Jordi
Ojeda Hernández, Doddy Denise
Fuente Martín, Sarah De La
Mohammed-Fathy Kamal, Ola
Benito Martín, María Soledad
Selma Calvo, Belén
Montero Escribano, Paloma
Matías-Guiu Guía, Jorge
author_role author
author2 Matias-Guiu Antem, Jordi
Ojeda Hernández, Doddy Denise
Fuente Martín, Sarah De La
Mohammed-Fathy Kamal, Ola
Benito Martín, María Soledad
Selma Calvo, Belén
Montero Escribano, Paloma
Matías-Guiu Guía, Jorge
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 61
Multiple sclerosis
HOG cells
oligodendrocyte precursor cells
oligodendrocytes
corticosteroids
demyelination
remyelination
Ciencias Biomédicas
32 Ciencias Médicas
topic 61
Multiple sclerosis
HOG cells
oligodendrocyte precursor cells
oligodendrocytes
corticosteroids
demyelination
remyelination
Ciencias Biomédicas
32 Ciencias Médicas
description The implantation of oligodendrocyte precursor cells may be a useful therapeutic strategy for targeting remyelination. However, it is yet to be established how these cells behave after implantation and whether they retain the capacity to proliferate or differentiate into myelin-forming oligodendrocytes. One essential issue is the creation of administration protocols and determining which factors need to be well established. There is controversy around whether these cells may be implanted simultaneously with corticosteroid treatment, which is widely used in many clinical situations. This study assesses the influence of corticosteroids on the capacity for proliferation and differentiation and the survival of human oligodendroglioma cells. Our findings show that corticosteroids reduce the capacity of these cells to proliferate and to differentiate into oligodendrocytes and decrease cell survival. Thus, their effect does not favour remyelination; this is consistent with the results of studies with rodent cells. In conclusion, protocols for the administration of oligodendrocyte lineage cells with the aim of repopulating oligodendroglial niches or repairing demyelinated axons should not include corticosteroids, given the evidence that the effects of these drugs may undermine the objectives of cell transplantation.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/104914
url https://hdl.handle.net/20.500.14352/104914
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv AES ISCIII PI21
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
ATTRIBUTION 4.0 INTERNATIONAL
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
ATTRIBUTION 4.0 INTERNATIONAL
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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