Epigenetic dysregulation of TET2 in human glioblastoma

Ten-eleven translocation (TET) enzymes are frequently deregulated in cancer, but the underlying molecular mechanisms are still poorly understood. Here we report that TET2 shows frequent epigenetic alterations in human glioblastoma including DNA hypermethylation and hypo-hydroxymethylation, as well a...

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Detalles Bibliográficos
Autores: García, María G., Carella, Antonella, Urdinguio, Rocío G., Bayón, Gustavo F., López, Virginia, Tejedor, Juan Ramón, Sierra, Marta I., García-Toraño, Estela, Santamarina-Ojeda, Pablo, Pérez, Raúl F., Mangas, Cristina, Astudillo, Aurora, Corte-Torres, M. Daniela, Sáenz-de-Santa-María, Inés, Chiara, María-Dolores, Fernández, Agustín F., Fraga, Mario F.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/173619
Acceso en línea:http://hdl.handle.net/10261/173619
Access Level:acceso abierto
Palabra clave:TET2
DNA methylation
Epigenetics
Glioblastoma
5-hydroxymehtylcytosine
Descripción
Sumario:Ten-eleven translocation (TET) enzymes are frequently deregulated in cancer, but the underlying molecular mechanisms are still poorly understood. Here we report that TET2 shows frequent epigenetic alterations in human glioblastoma including DNA hypermethylation and hypo-hydroxymethylation, as well as loss of histone acetylation. Ectopic overexpression of TET2 regulated neural differentiation in glioblastoma cell lines and impaired tumor growth. Our results suggest that epigenetic dysregulation of TET2 plays a role in human glioblastoma.

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