Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response

Background After sustained virological response (SVR), liver stiffness (LS) usually decreases. However, information related to the impact of HIV co-infection in patients with advanced fibrosis is scarce. The aim was to analyze the impact of HIV co-infection on the LS dynamics after HCV cure. Methods...

Descripción completa

Detalles Bibliográficos
Autores: Martín Carmona, Jésica, Corma Gómez, Anaïs, Moyano Murillo, José María, Téllez Pérez, Francisco de Paula, Arenga Barrios, Dolores, Serrano Fuentes, Miriam, Morano Vázquez, Aitana Carla, Corona Mata, Diana, Navarrete Lorite, Miguel Nicolás, Vera Méndez, Francisco, Barroso, Isabel, Palacios, Rosario, Santos, Ignacio de los, Belinchón, Olga, Galera, Carlos, Imaz, Arkaitz, Merino, Dolores, Reus Bañuls, Sergio, Galindo, María José, López Zuñiga, Miguel Ángel, Pineda, Juan Antonio, Macías, Juan, GEHEP-011 Study Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/222075
Acceso en línea:https://hdl.handle.net/2445/222075
Access Level:acceso abierto
Palabra clave:Virus de l'hepatitis C
Infeccions per VIH
Hepatitis C virus
HIV infections
id ES_56cd8093e6bd81bb7fa00a1a9f62b575
oai_identifier_str oai:recercat.cat:2445/222075
network_acronym_str ES
network_name_str España
repository_id_str
spelling Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological responseMartín Carmona, JésicaCorma Gómez, AnaïsMoyano Murillo, José MaríaTéllez Pérez, Francisco de PaulaArenga Barrios, DoloresSerrano Fuentes, MiriamMorano Vázquez, Aitana CarlaCorona Mata, DianaNavarrete Lorite, Miguel NicolásVera Méndez, FranciscoBarroso, IsabelPalacios, RosarioSantos, Ignacio de losBelinchón, OlgaGalera, CarlosImaz, ArkaitzMerino, DoloresReus Bañuls, SergioGalindo, María JoséLópez Zuñiga, Miguel ÁngelPineda, Juan AntonioMacías, JuanGEHEP-011 Study GroupVirus de l'hepatitis CInfeccions per VIHHepatitis C virusHIV infectionsBackground After sustained virological response (SVR), liver stiffness (LS) usually decreases. However, information related to the impact of HIV co-infection in patients with advanced fibrosis is scarce. The aim was to analyze the impact of HIV co-infection on the LS dynamics after HCV cure. Methods Prospective study conducted in the GEHEP-011 multicenter cohort (initiated in October 2011-November 2023, ID NCT04460157), including patients with chronic HCV infection, with or without HIV co-infection, fulfilling: 1) SVR with direct-acting antivirals; 2) pre-treatment LS >= 9.5 kPa; 3) available measurement of LS at SVR. Pre-treatment, SVR and annual post-treatment LS were assessed. The primary outcome was time to LS normalization achievement (<= 7.2 kPa) in two consecutive examinations. Findings 1138 patients were included, 678 (60%) of whom were living with HIV (PLWH). The median time between the first to the last measure was 35 (17-69) months. In total, 390 [34% (95% confidence interval, 31%-37%)] patients achieved LS normalization, 169 [37% (CI 95%, 34%-43%)] individuals with HCV mono-infection vs. 221 [32% (CI 95%, 29%-36%)] PLWH achieved LS normalization (p = 0.003). The propensity score (PS) for HIV infection was calculated. In a multivariate model for competing risks (death was the competing event) adjusted for HIV, PS and diabetes, HIV infection was associated with a lower probability of achieving normalization [sHR = 0.82 (95% CI, 0.67-1.00), p = 0.045]. Matching by closer PS was performed. In the resultant subset, the probability of achieving LS normalization was again lower in PLWH [sHR = 0.76 (0.56-0.97), p < 0.001]. Interpretation After SVR, the probability of reaching LS normalization is significantly lower in PLWH. This could have implications on the development of long-term clinical events. Copyright (c) 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).Elsevier BV2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/222075Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.eclinm.2025.103227EClinicalMedicine, 2025, vol. 83, 103227https://doi.org/10.1016/j.eclinm.2025.103227cc-by-nc (c) Martín Carmona et al., 2025http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2220752026-05-29T05:05:01Z
dc.title.none.fl_str_mv Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
title Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
spellingShingle Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
Martín Carmona, Jésica
Virus de l'hepatitis C
Infeccions per VIH
Hepatitis C virus
HIV infections
title_short Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
title_full Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
title_fullStr Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
title_full_unstemmed Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
title_sort Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
dc.creator.none.fl_str_mv Martín Carmona, Jésica
Corma Gómez, Anaïs
Moyano Murillo, José María
Téllez Pérez, Francisco de Paula
Arenga Barrios, Dolores
Serrano Fuentes, Miriam
Morano Vázquez, Aitana Carla
Corona Mata, Diana
Navarrete Lorite, Miguel Nicolás
Vera Méndez, Francisco
Barroso, Isabel
Palacios, Rosario
Santos, Ignacio de los
Belinchón, Olga
Galera, Carlos
Imaz, Arkaitz
Merino, Dolores
Reus Bañuls, Sergio
Galindo, María José
López Zuñiga, Miguel Ángel
Pineda, Juan Antonio
Macías, Juan
GEHEP-011 Study Group
author Martín Carmona, Jésica
author_facet Martín Carmona, Jésica
Corma Gómez, Anaïs
Moyano Murillo, José María
Téllez Pérez, Francisco de Paula
Arenga Barrios, Dolores
Serrano Fuentes, Miriam
Morano Vázquez, Aitana Carla
Corona Mata, Diana
Navarrete Lorite, Miguel Nicolás
Vera Méndez, Francisco
Barroso, Isabel
Palacios, Rosario
Santos, Ignacio de los
Belinchón, Olga
Galera, Carlos
Imaz, Arkaitz
Merino, Dolores
Reus Bañuls, Sergio
Galindo, María José
López Zuñiga, Miguel Ángel
Pineda, Juan Antonio
Macías, Juan
GEHEP-011 Study Group
author_role author
author2 Corma Gómez, Anaïs
Moyano Murillo, José María
Téllez Pérez, Francisco de Paula
Arenga Barrios, Dolores
Serrano Fuentes, Miriam
Morano Vázquez, Aitana Carla
Corona Mata, Diana
Navarrete Lorite, Miguel Nicolás
Vera Méndez, Francisco
Barroso, Isabel
Palacios, Rosario
Santos, Ignacio de los
Belinchón, Olga
Galera, Carlos
Imaz, Arkaitz
Merino, Dolores
Reus Bañuls, Sergio
Galindo, María José
López Zuñiga, Miguel Ángel
Pineda, Juan Antonio
Macías, Juan
GEHEP-011 Study Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Virus de l'hepatitis C
Infeccions per VIH
Hepatitis C virus
HIV infections
topic Virus de l'hepatitis C
Infeccions per VIH
Hepatitis C virus
HIV infections
description Background After sustained virological response (SVR), liver stiffness (LS) usually decreases. However, information related to the impact of HIV co-infection in patients with advanced fibrosis is scarce. The aim was to analyze the impact of HIV co-infection on the LS dynamics after HCV cure. Methods Prospective study conducted in the GEHEP-011 multicenter cohort (initiated in October 2011-November 2023, ID NCT04460157), including patients with chronic HCV infection, with or without HIV co-infection, fulfilling: 1) SVR with direct-acting antivirals; 2) pre-treatment LS >= 9.5 kPa; 3) available measurement of LS at SVR. Pre-treatment, SVR and annual post-treatment LS were assessed. The primary outcome was time to LS normalization achievement (<= 7.2 kPa) in two consecutive examinations. Findings 1138 patients were included, 678 (60%) of whom were living with HIV (PLWH). The median time between the first to the last measure was 35 (17-69) months. In total, 390 [34% (95% confidence interval, 31%-37%)] patients achieved LS normalization, 169 [37% (CI 95%, 34%-43%)] individuals with HCV mono-infection vs. 221 [32% (CI 95%, 29%-36%)] PLWH achieved LS normalization (p = 0.003). The propensity score (PS) for HIV infection was calculated. In a multivariate model for competing risks (death was the competing event) adjusted for HIV, PS and diabetes, HIV infection was associated with a lower probability of achieving normalization [sHR = 0.82 (95% CI, 0.67-1.00), p = 0.045]. Matching by closer PS was performed. In the resultant subset, the probability of achieving LS normalization was again lower in PLWH [sHR = 0.76 (0.56-0.97), p < 0.001]. Interpretation After SVR, the probability of reaching LS normalization is significantly lower in PLWH. This could have implications on the development of long-term clinical events. Copyright (c) 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/222075
url https://hdl.handle.net/2445/222075
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.eclinm.2025.103227
EClinicalMedicine, 2025, vol. 83, 103227
https://doi.org/10.1016/j.eclinm.2025.103227
dc.rights.none.fl_str_mv cc-by-nc (c) Martín Carmona et al., 2025
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Martín Carmona et al., 2025
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408406007185408
score 15.81155

Similares en LA Referencia