Sarcopenia and Mild Cognitive Impairment in Older Adults from Six Low- and Middle-Income Countries.

BACKGROUND: Little is known about the relationship between sarcopenia and mild cognitive impairment (MCI) in low- and middle-income countries (LMICs). OBJECTIVE: This study aimed to investigate this association among community-dwelling adults aged=65 years from six LMICs. METHODS: Cross-sectional, n...

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Autores: Jacob L, Kostev K, Smith L, Oh H, López-Sánchez GF, Shin JI, Abduljabbar AS, Haro JM, Koyanagi A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p19825
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19825
Access Level:acceso abierto
Palabra clave:*Community-dwelling adults
*low- and middle-income countries
*mild cognitive impairment
*multicountry study
*sarcopenia
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spelling Sarcopenia and Mild Cognitive Impairment in Older Adults from Six Low- and Middle-Income Countries.Jacob LKostev KSmith LOh HLópez-Sánchez GFShin JIAbduljabbar ASHaro JMKoyanagi A*Community-dwelling adults*low- and middle-income countries*mild cognitive impairment*multicountry study*sarcopeniaBACKGROUND: Little is known about the relationship between sarcopenia and mild cognitive impairment (MCI) in low- and middle-income countries (LMICs). OBJECTIVE: This study aimed to investigate this association among community-dwelling adults aged=65 years from six LMICs. METHODS: Cross-sectional, nationally representative data from the Study on Global Ageing and Adult Health (SAGE) were analyzed. These data were obtained in China, Ghana, India, Mexico, Russia, and South Africa in 2007-2010. Participants were considered to have sarcopenia if they had low skeletal muscle mass (i.e., lower skeletal mass index) and a weak handgrip strength. MCI was defined using the National Institute on Aging-Alzheimer's Association criteria. Multivariable logistic regression analysis was conducted to assess associations. RESULTS: The final analytical sample consisted of 12,912 individuals aged=65 years with preservation in functional abilities without stroke (mean [standard deviation] age 72.2 [10.8] years; 45.2% males). The overall prevalence of sarcopenia and MCI were 11.3% and 18.1%, respectively. After adjusting for potential confounders, there was a positive association between sarcopenia and MCI in all countries (i.e., odds ratio [OR] > 1) with the exception of South Africa, and the overall estimate was OR = 1.60 (95% confidence interval [CI] = 1.32-1.93) with a low level of between-country heterogeneity (I2 = 0.0%). CONCLUSION: There was a positive association between sarcopenia and MCI in this sample of older adults living in LMICs. Causality should be assessed in future longitudinal research, while the utility of sarcopenia as a marker of MCI should also be investigated.SAGE PUBLICATIONS LTD2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19825JOURNAL OF ALZHEIMERS DISEASEISSN: 13872877ISSNe: 18758908reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p198252026-05-27T12:37:41Z
dc.title.none.fl_str_mv Sarcopenia and Mild Cognitive Impairment in Older Adults from Six Low- and Middle-Income Countries.
title Sarcopenia and Mild Cognitive Impairment in Older Adults from Six Low- and Middle-Income Countries.
spellingShingle Sarcopenia and Mild Cognitive Impairment in Older Adults from Six Low- and Middle-Income Countries.
Jacob L
*Community-dwelling adults
*low- and middle-income countries
*mild cognitive impairment
*multicountry study
*sarcopenia
title_short Sarcopenia and Mild Cognitive Impairment in Older Adults from Six Low- and Middle-Income Countries.
title_full Sarcopenia and Mild Cognitive Impairment in Older Adults from Six Low- and Middle-Income Countries.
title_fullStr Sarcopenia and Mild Cognitive Impairment in Older Adults from Six Low- and Middle-Income Countries.
title_full_unstemmed Sarcopenia and Mild Cognitive Impairment in Older Adults from Six Low- and Middle-Income Countries.
title_sort Sarcopenia and Mild Cognitive Impairment in Older Adults from Six Low- and Middle-Income Countries.
dc.creator.none.fl_str_mv Jacob L
Kostev K
Smith L
Oh H
López-Sánchez GF
Shin JI
Abduljabbar AS
Haro JM
Koyanagi A
author Jacob L
author_facet Jacob L
Kostev K
Smith L
Oh H
López-Sánchez GF
Shin JI
Abduljabbar AS
Haro JM
Koyanagi A
author_role author
author2 Kostev K
Smith L
Oh H
López-Sánchez GF
Shin JI
Abduljabbar AS
Haro JM
Koyanagi A
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv *Community-dwelling adults
*low- and middle-income countries
*mild cognitive impairment
*multicountry study
*sarcopenia
topic *Community-dwelling adults
*low- and middle-income countries
*mild cognitive impairment
*multicountry study
*sarcopenia
description BACKGROUND: Little is known about the relationship between sarcopenia and mild cognitive impairment (MCI) in low- and middle-income countries (LMICs). OBJECTIVE: This study aimed to investigate this association among community-dwelling adults aged=65 years from six LMICs. METHODS: Cross-sectional, nationally representative data from the Study on Global Ageing and Adult Health (SAGE) were analyzed. These data were obtained in China, Ghana, India, Mexico, Russia, and South Africa in 2007-2010. Participants were considered to have sarcopenia if they had low skeletal muscle mass (i.e., lower skeletal mass index) and a weak handgrip strength. MCI was defined using the National Institute on Aging-Alzheimer's Association criteria. Multivariable logistic regression analysis was conducted to assess associations. RESULTS: The final analytical sample consisted of 12,912 individuals aged=65 years with preservation in functional abilities without stroke (mean [standard deviation] age 72.2 [10.8] years; 45.2% males). The overall prevalence of sarcopenia and MCI were 11.3% and 18.1%, respectively. After adjusting for potential confounders, there was a positive association between sarcopenia and MCI in all countries (i.e., odds ratio [OR] > 1) with the exception of South Africa, and the overall estimate was OR = 1.60 (95% confidence interval [CI] = 1.32-1.93) with a low level of between-country heterogeneity (I2 = 0.0%). CONCLUSION: There was a positive association between sarcopenia and MCI in this sample of older adults living in LMICs. Causality should be assessed in future longitudinal research, while the utility of sarcopenia as a marker of MCI should also be investigated.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19825
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19825
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SAGE PUBLICATIONS LTD
publisher.none.fl_str_mv SAGE PUBLICATIONS LTD
dc.source.none.fl_str_mv JOURNAL OF ALZHEIMERS DISEASE
ISSN: 13872877
ISSNe: 18758908
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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