Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease.

Increasing evidence shows that conventional cardiovascular risk factors are incompletely predictive of cardiovascular disease, particularly in elderly individuals, suggesting that there may still be unidentified causal risk factors. Although the accumulation of somatic DNA mutations is a hallmark of...

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Detalles Bibliográficos
Autores: Fuster, José J, Walsh, Kenneth
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17501
Acceso en línea:http://hdl.handle.net/20.500.12105/17501
Access Level:acceso abierto
Palabra clave:Mutation
Aged
Aging
Animals
Atherosclerosis
Bone Marrow Transplantation
Cardiovascular Diseases
Causality
Clone Cells
DNA (Cytosine-5-)-Methyltransferases
DNA Methyltransferase 3A
DNA-Binding Proteins
Dioxygenases
Genes, Neoplasm
Genetic Association Studies
Hematologic Neoplasms
Hematopoiesis
Hematopoietic Stem Cells
Humans
Janus Kinase 2
Mice
Population Dynamics
Precision Medicine
Proto-Oncogene Proteins
Risk Factors
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spelling Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease.Fuster, José JWalsh, KennethMutationAgedAgingAnimalsAtherosclerosisBone Marrow TransplantationCardiovascular DiseasesCausalityClone CellsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA-Binding ProteinsDioxygenasesGenes, NeoplasmGenetic Association StudiesHematologic NeoplasmsHematopoiesisHematopoietic Stem CellsHumansJanus Kinase 2MicePopulation DynamicsPrecision MedicineProto-Oncogene ProteinsRisk FactorsIncreasing evidence shows that conventional cardiovascular risk factors are incompletely predictive of cardiovascular disease, particularly in elderly individuals, suggesting that there may still be unidentified causal risk factors. Although the accumulation of somatic DNA mutations is a hallmark of aging, its relevance in cardiovascular disease or other age-related conditions has been, with the exception of cancer, largely unexplored. Here, we review recent clinical and preclinical studies that have identified acquired mutations in hematopoietic stem cells and subsequent clonal hematopoiesis as a new cardiovascular risk factor and a potential major driver of atherosclerosis. Understanding the mechanisms underlying the connection between somatic mutation-driven clonal hematopoiesis and cardiovascular disease will be highly relevant in the context of personalized medicine, as it may provide key information for the design of diagnostic, preventive, or therapeutic strategies tailored to the effects of specific somatic mutations.Lippincott Williams & Wilkins (LWW)20242024-02-0620182018-02-0220182018-02-02journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/17501reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/175012026-06-12T12:43:37Z
dc.title.none.fl_str_mv Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease.
title Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease.
spellingShingle Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease.
Fuster, José J
Mutation
Aged
Aging
Animals
Atherosclerosis
Bone Marrow Transplantation
Cardiovascular Diseases
Causality
Clone Cells
DNA (Cytosine-5-)-Methyltransferases
DNA Methyltransferase 3A
DNA-Binding Proteins
Dioxygenases
Genes, Neoplasm
Genetic Association Studies
Hematologic Neoplasms
Hematopoiesis
Hematopoietic Stem Cells
Humans
Janus Kinase 2
Mice
Population Dynamics
Precision Medicine
Proto-Oncogene Proteins
Risk Factors
title_short Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease.
title_full Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease.
title_fullStr Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease.
title_full_unstemmed Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease.
title_sort Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease.
dc.creator.none.fl_str_mv Fuster, José J
Walsh, Kenneth
author Fuster, José J
author_facet Fuster, José J
Walsh, Kenneth
author_role author
author2 Walsh, Kenneth
author2_role author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Mutation
Aged
Aging
Animals
Atherosclerosis
Bone Marrow Transplantation
Cardiovascular Diseases
Causality
Clone Cells
DNA (Cytosine-5-)-Methyltransferases
DNA Methyltransferase 3A
DNA-Binding Proteins
Dioxygenases
Genes, Neoplasm
Genetic Association Studies
Hematologic Neoplasms
Hematopoiesis
Hematopoietic Stem Cells
Humans
Janus Kinase 2
Mice
Population Dynamics
Precision Medicine
Proto-Oncogene Proteins
Risk Factors
topic Mutation
Aged
Aging
Animals
Atherosclerosis
Bone Marrow Transplantation
Cardiovascular Diseases
Causality
Clone Cells
DNA (Cytosine-5-)-Methyltransferases
DNA Methyltransferase 3A
DNA-Binding Proteins
Dioxygenases
Genes, Neoplasm
Genetic Association Studies
Hematologic Neoplasms
Hematopoiesis
Hematopoietic Stem Cells
Humans
Janus Kinase 2
Mice
Population Dynamics
Precision Medicine
Proto-Oncogene Proteins
Risk Factors
description Increasing evidence shows that conventional cardiovascular risk factors are incompletely predictive of cardiovascular disease, particularly in elderly individuals, suggesting that there may still be unidentified causal risk factors. Although the accumulation of somatic DNA mutations is a hallmark of aging, its relevance in cardiovascular disease or other age-related conditions has been, with the exception of cancer, largely unexplored. Here, we review recent clinical and preclinical studies that have identified acquired mutations in hematopoietic stem cells and subsequent clonal hematopoiesis as a new cardiovascular risk factor and a potential major driver of atherosclerosis. Understanding the mechanisms underlying the connection between somatic mutation-driven clonal hematopoiesis and cardiovascular disease will be highly relevant in the context of personalized medicine, as it may provide key information for the design of diagnostic, preventive, or therapeutic strategies tailored to the effects of specific somatic mutations.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-02-02
2018
2018-02-02
2024
2024-02-06
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/17501
url http://hdl.handle.net/20.500.12105/17501
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins (LWW)
publisher.none.fl_str_mv Lippincott Williams & Wilkins (LWW)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408400099508224
score 15.812455

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