Cardiovascular risk and white matter lesions after endocrine control of Cushing's syndrome

Objective: Cushing's syndrome (CS) is associated with high cardiovascular risk. White matter lesions (WML) are common on brain magnetic resonance imaging (MRI) in patients with increased cardiovascular risk. AIM: To investigate the relationship between cardiovascular risk, WML, neuropsychologic...

Descripción completa

Detalles Bibliográficos
Autores: Santos Vives, Alicia, Resmini, Eugenia, Gómez-Ansón, Beatriz, Crespo, Iris, Granell, Esther, Valassi, Elena, Pires, Patricia, Vives-Gilabert, Yolanda, Martínez Momblán, Ma. Antonia, Juan, Manuel de, Mataró Serrat, Maria, Webb, S. M. (Susan M.), 1952-
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/119115
Acceso en línea:https://hdl.handle.net/2445/119115
Access Level:acceso abierto
Palabra clave:Síndrome de Cushing
Malalties cardiovasculars
Endocrinologia
Cushing's syndrome
Cardiovascular diseases
Endocrinology
id ES_56ac6d945d5e7d79d88c69ea3c09ca21
oai_identifier_str oai:recercat.cat:2445/119115
network_acronym_str ES
network_name_str España
repository_id_str
spelling Cardiovascular risk and white matter lesions after endocrine control of Cushing's syndromeSantos Vives, AliciaResmini, EugeniaGómez-Ansón, BeatrizCrespo, IrisGranell, EstherValassi, ElenaPires, PatriciaVives-Gilabert, YolandaMartínez Momblán, Ma. AntoniaJuan, Manuel deMataró Serrat, MariaWebb, S. M. (Susan M.), 1952-Síndrome de CushingMalalties cardiovascularsEndocrinologiaCushing's syndromeCardiovascular diseasesEndocrinologyObjective: Cushing's syndrome (CS) is associated with high cardiovascular risk. White matter lesions (WML) are common on brain magnetic resonance imaging (MRI) in patients with increased cardiovascular risk. AIM: To investigate the relationship between cardiovascular risk, WML, neuropsychological performance and brain volume in CS. Design/methods: Thirty-eight patients with CS (23 in remission, 15 active) and 38 controls sex-, age- and education-level matched underwent a neuropsychological and clinical evaluation, blood and urine tests and 3Tesla brain MRI. WML were analysed with the Scheltens scale. Ten-year cardiovascular risk (10CVR) and vascular age (VA) were calculated according to an algorithm based on the Framingham heart study. Results: Patients in remission had a higher degree of WML than controls and active patients (P<0.001 and P=0.008 respectively), which did not correlate with cognitive performance in any group. WML severity positively correlated with diastolic blood pressure (r=0.659, P=0.001) and duration of hypertension (r=0.478, P=0.021) in patients in remission. Both patient groups (active and in remission) had higher 10CVR (P=0.030, P=0.041) and VA than controls (P=0.013, P=0.039). Neither the 10CVR nor the VA correlated with WML, although both negatively correlated with cognitive function and brain volume in patients in remission (P<0.05). Total brain volume and grey matter volume in both CS patient groups were reduced compared to controls (total volume: active P=0.006, in remission P=0.012; grey matter: active P=0.001, in remission P=0.003), with no differences in white matter volume between groups. Conclusions: Patients in remission of Cushing's syndrome (but not active patients) have more severe white matter lesions than controls, positively correlated with diastolic pressure and duration of hypertension. Ten-year cardiovascular risk and vascular age appear to be negatively correlated with the cognitive function and brain volume in patients in remission of Cushing's syndrome.Bioscientifica2018201820152018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion11 p.application/pdfhttps://hdl.handle.net/2445/119115Articles publicats en revistes (Infermeria Fonamental i Clínica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)EspañolVersió postprint del document publicat a: http://www.eje-online.org/content/173/6/765.longEuropean Journal of Endocrinology, 2015, vol. 173, num. 6, p. 765-775(c) European Society of Endocrinology, 2015info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1191152026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cardiovascular risk and white matter lesions after endocrine control of Cushing's syndrome
title Cardiovascular risk and white matter lesions after endocrine control of Cushing's syndrome
spellingShingle Cardiovascular risk and white matter lesions after endocrine control of Cushing's syndrome
Santos Vives, Alicia
Síndrome de Cushing
Malalties cardiovasculars
Endocrinologia
Cushing's syndrome
Cardiovascular diseases
Endocrinology
title_short Cardiovascular risk and white matter lesions after endocrine control of Cushing's syndrome
title_full Cardiovascular risk and white matter lesions after endocrine control of Cushing's syndrome
title_fullStr Cardiovascular risk and white matter lesions after endocrine control of Cushing's syndrome
title_full_unstemmed Cardiovascular risk and white matter lesions after endocrine control of Cushing's syndrome
title_sort Cardiovascular risk and white matter lesions after endocrine control of Cushing's syndrome
dc.creator.none.fl_str_mv Santos Vives, Alicia
Resmini, Eugenia
Gómez-Ansón, Beatriz
Crespo, Iris
Granell, Esther
Valassi, Elena
Pires, Patricia
Vives-Gilabert, Yolanda
Martínez Momblán, Ma. Antonia
Juan, Manuel de
Mataró Serrat, Maria
Webb, S. M. (Susan M.), 1952-
author Santos Vives, Alicia
author_facet Santos Vives, Alicia
Resmini, Eugenia
Gómez-Ansón, Beatriz
Crespo, Iris
Granell, Esther
Valassi, Elena
Pires, Patricia
Vives-Gilabert, Yolanda
Martínez Momblán, Ma. Antonia
Juan, Manuel de
Mataró Serrat, Maria
Webb, S. M. (Susan M.), 1952-
author_role author
author2 Resmini, Eugenia
Gómez-Ansón, Beatriz
Crespo, Iris
Granell, Esther
Valassi, Elena
Pires, Patricia
Vives-Gilabert, Yolanda
Martínez Momblán, Ma. Antonia
Juan, Manuel de
Mataró Serrat, Maria
Webb, S. M. (Susan M.), 1952-
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Síndrome de Cushing
Malalties cardiovasculars
Endocrinologia
Cushing's syndrome
Cardiovascular diseases
Endocrinology
topic Síndrome de Cushing
Malalties cardiovasculars
Endocrinologia
Cushing's syndrome
Cardiovascular diseases
Endocrinology
description Objective: Cushing's syndrome (CS) is associated with high cardiovascular risk. White matter lesions (WML) are common on brain magnetic resonance imaging (MRI) in patients with increased cardiovascular risk. AIM: To investigate the relationship between cardiovascular risk, WML, neuropsychological performance and brain volume in CS. Design/methods: Thirty-eight patients with CS (23 in remission, 15 active) and 38 controls sex-, age- and education-level matched underwent a neuropsychological and clinical evaluation, blood and urine tests and 3Tesla brain MRI. WML were analysed with the Scheltens scale. Ten-year cardiovascular risk (10CVR) and vascular age (VA) were calculated according to an algorithm based on the Framingham heart study. Results: Patients in remission had a higher degree of WML than controls and active patients (P<0.001 and P=0.008 respectively), which did not correlate with cognitive performance in any group. WML severity positively correlated with diastolic blood pressure (r=0.659, P=0.001) and duration of hypertension (r=0.478, P=0.021) in patients in remission. Both patient groups (active and in remission) had higher 10CVR (P=0.030, P=0.041) and VA than controls (P=0.013, P=0.039). Neither the 10CVR nor the VA correlated with WML, although both negatively correlated with cognitive function and brain volume in patients in remission (P<0.05). Total brain volume and grey matter volume in both CS patient groups were reduced compared to controls (total volume: active P=0.006, in remission P=0.012; grey matter: active P=0.001, in remission P=0.003), with no differences in white matter volume between groups. Conclusions: Patients in remission of Cushing's syndrome (but not active patients) have more severe white matter lesions than controls, positively correlated with diastolic pressure and duration of hypertension. Ten-year cardiovascular risk and vascular age appear to be negatively correlated with the cognitive function and brain volume in patients in remission of Cushing's syndrome.
publishDate 2015
dc.date.none.fl_str_mv 2015
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/119115
url https://hdl.handle.net/2445/119115
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.relation.none.fl_str_mv Versió postprint del document publicat a: http://www.eje-online.org/content/173/6/765.long
European Journal of Endocrinology, 2015, vol. 173, num. 6, p. 765-775
dc.rights.none.fl_str_mv (c) European Society of Endocrinology, 2015
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) European Society of Endocrinology, 2015
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Bioscientifica
publisher.none.fl_str_mv Bioscientifica
dc.source.none.fl_str_mv Articles publicats en revistes (Infermeria Fonamental i Clínica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408396928614400
score 15,811543

Similares en LA Referencia