Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry.
BACKGROUND: Limited data are available on the management and outcomes of postoperative Crohn's disease (CD) in older patients. We aimed to describe the management of CD in the postoperative setting and assess surgical postoperative recurrence (POR) in this population. METHODS: This was a case-c...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Recursos: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositorio: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:fisabio.fundanetsuite.com:p19931 |
| Acesso em linha: | https://fisabio.portalinvestigacion.com/publicaciones/19931 |
| Access Level: | acceso abierto |
| Palavra-chave: | Crohn's disease older postoperative recurrence surgery |
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oai:fisabio.fundanetsuite.com:p19931 |
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Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry.Mañosa MCalafat MRicart ENos PIglesias ERiestra SMesonero FCalvo MGuardiola JHernández VRivero MCarpio DMínguez MAlba CMartín-Arranz MDVela MGomollón FGarcía-López SCasbas AGCalvet XGonzález-Muñoza CBarrio JGisbert JPSicilia BPérez-Calle JLBujanda LEsteve MRamos LVarela PSierra MMerino OBermejo FAcosta MBPerez ARMárquez-Mosquera LGarcía-Bosch ORodríguez-Lago ILorente Poyatos RHGarcía Sepulcre MFMaroto NVega PMonfort DSan Martín LZBusquets DMartinez-Montiel PRiera JAlcain GLlaó JMarin NMarin-Jimenez ISesé EVan Domselaar MHuguet JMGinard DBas-Cutrina FBer YRoncero OLucendo AJLópez-García AMenacho MAlmela PPonferrada ÁCoronel AFMaestro Sde Jesús Martínez-Pérez TVilafranca CMArgüelles FLegido JGilabert PCharro MTrapero AMFernández HFrago SVillalba LHMuñoz EDomènech ECrohn's diseaseolderpostoperative recurrencesurgeryBACKGROUND: Limited data are available on the management and outcomes of postoperative Crohn's disease (CD) in older patients. We aimed to describe the management of CD in the postoperative setting and assess surgical postoperative recurrence (POR) in this population. METHODS: This was a case-control study including all adult patients with CD from the ENEIDA registry who had undergone a first intestinal resection with ileo-colonic anastomosis. Patients were grouped according to their age at the time of the first surgery in older (over 60 years) subjects and controls (between 18 and 60 years of age). RESULTS: A total of 3982 (535 older subjects and 3454 controls) underwent a first intestinal resection for CD with an ileo-colonic anastomosis. Time from CD diagnosis to surgery was significantly longer in older patients (114 ± 128 vs. 93 ± 97 months; p < 0.001). Older patients also had a lower proportion of penetrating CD (25% vs. 39%; p < 0.0001) and perianal disease (14% vs. 25%; p < 0.0001). A significantly lower proportion of older patients started preventive therapies for POR (32% vs. 51%; p < 0.0001). The cumulative risk of surgical POR was 3.2%, 5.3% and 10.1% in the older group and 3.6%, 6.6% and 14.2% in the control group at three, five and 10 years, respectively (p = 0.093). In the multivariate logistic regression analysis, only prevention with thiopurines was associated with a lower risk of surgical POR. CONCLUSIONS: Although postoperative preventive therapy with immunomodulators or biologicals is prescribed less often in older patients after a first intestinal resection, they develop surgical POR as often as younger adult patients.JOHN WILEY & SONS LTD2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/19931United European Gastroenterology JournalISSN: 20506406ISSNe: 20506414reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p199312026-06-11T12:45:17Z |
| dc.title.none.fl_str_mv |
Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry. |
| title |
Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry. |
| spellingShingle |
Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry. Mañosa M Crohn's disease older postoperative recurrence surgery |
| title_short |
Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry. |
| title_full |
Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry. |
| title_fullStr |
Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry. |
| title_full_unstemmed |
Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry. |
| title_sort |
Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry. |
| dc.creator.none.fl_str_mv |
Mañosa M Calafat M Ricart E Nos P Iglesias E Riestra S Mesonero F Calvo M Guardiola J Hernández V Rivero M Carpio D Mínguez M Alba C Martín-Arranz MD Vela M Gomollón F García-López S Casbas AG Calvet X González-Muñoza C Barrio J Gisbert JP Sicilia B Pérez-Calle JL Bujanda L Esteve M Ramos L Varela P Sierra M Merino O Bermejo F Acosta MB Perez AR Márquez-Mosquera L García-Bosch O Rodríguez-Lago I Lorente Poyatos RH García Sepulcre MF Maroto N Vega P Monfort D San Martín LZ Busquets D Martinez-Montiel P Riera J Alcain G Llaó J Marin N Marin-Jimenez I Sesé E Van Domselaar M Huguet JM Ginard D Bas-Cutrina F Ber Y Roncero O Lucendo AJ López-García A Menacho M Almela P Ponferrada Á Coronel AF Maestro S de Jesús Martínez-Pérez T Vilafranca CM Argüelles F Legido J Gilabert P Charro M Trapero AM Fernández H Frago S Villalba LH Muñoz E Domènech E |
| author |
Mañosa M |
| author_facet |
Mañosa M Calafat M Ricart E Nos P Iglesias E Riestra S Mesonero F Calvo M Guardiola J Hernández V Rivero M Carpio D Mínguez M Alba C Martín-Arranz MD Vela M Gomollón F García-López S Casbas AG Calvet X González-Muñoza C Barrio J Gisbert JP Sicilia B Pérez-Calle JL Bujanda L Esteve M Ramos L Varela P Sierra M Merino O Bermejo F Acosta MB Perez AR Márquez-Mosquera L García-Bosch O Rodríguez-Lago I Lorente Poyatos RH García Sepulcre MF Maroto N Vega P Monfort D San Martín LZ Busquets D Martinez-Montiel P Riera J Alcain G Llaó J Marin N Marin-Jimenez I Sesé E Van Domselaar M Huguet JM Ginard D Bas-Cutrina F Ber Y Roncero O Lucendo AJ López-García A Menacho M Almela P Ponferrada Á Coronel AF Maestro S de Jesús Martínez-Pérez T Vilafranca CM Argüelles F Legido J Gilabert P Charro M Trapero AM Fernández H Frago S Villalba LH Muñoz E Domènech E |
| author_role |
author |
| author2 |
Calafat M Ricart E Nos P Iglesias E Riestra S Mesonero F Calvo M Guardiola J Hernández V Rivero M Carpio D Mínguez M Alba C Martín-Arranz MD Vela M Gomollón F García-López S Casbas AG Calvet X González-Muñoza C Barrio J Gisbert JP Sicilia B Pérez-Calle JL Bujanda L Esteve M Ramos L Varela P Sierra M Merino O Bermejo F Acosta MB Perez AR Márquez-Mosquera L García-Bosch O Rodríguez-Lago I Lorente Poyatos RH García Sepulcre MF Maroto N Vega P Monfort D San Martín LZ Busquets D Martinez-Montiel P Riera J Alcain G Llaó J Marin N Marin-Jimenez I Sesé E Van Domselaar M Huguet JM Ginard D Bas-Cutrina F Ber Y Roncero O Lucendo AJ López-García A Menacho M Almela P Ponferrada Á Coronel AF Maestro S de Jesús Martínez-Pérez T Vilafranca CM Argüelles F Legido J Gilabert P Charro M Trapero AM Fernández H Frago S Villalba LH Muñoz E Domènech E |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Crohn's disease older postoperative recurrence surgery |
| topic |
Crohn's disease older postoperative recurrence surgery |
| description |
BACKGROUND: Limited data are available on the management and outcomes of postoperative Crohn's disease (CD) in older patients. We aimed to describe the management of CD in the postoperative setting and assess surgical postoperative recurrence (POR) in this population. METHODS: This was a case-control study including all adult patients with CD from the ENEIDA registry who had undergone a first intestinal resection with ileo-colonic anastomosis. Patients were grouped according to their age at the time of the first surgery in older (over 60 years) subjects and controls (between 18 and 60 years of age). RESULTS: A total of 3982 (535 older subjects and 3454 controls) underwent a first intestinal resection for CD with an ileo-colonic anastomosis. Time from CD diagnosis to surgery was significantly longer in older patients (114 ± 128 vs. 93 ± 97 months; p < 0.001). Older patients also had a lower proportion of penetrating CD (25% vs. 39%; p < 0.0001) and perianal disease (14% vs. 25%; p < 0.0001). A significantly lower proportion of older patients started preventive therapies for POR (32% vs. 51%; p < 0.0001). The cumulative risk of surgical POR was 3.2%, 5.3% and 10.1% in the older group and 3.6%, 6.6% and 14.2% in the control group at three, five and 10 years, respectively (p = 0.093). In the multivariate logistic regression analysis, only prevention with thiopurines was associated with a lower risk of surgical POR. CONCLUSIONS: Although postoperative preventive therapy with immunomodulators or biologicals is prescribed less often in older patients after a first intestinal resection, they develop surgical POR as often as younger adult patients. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://fisabio.portalinvestigacion.com/publicaciones/19931 |
| url |
https://fisabio.portalinvestigacion.com/publicaciones/19931 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
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info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
JOHN WILEY & SONS LTD |
| publisher.none.fl_str_mv |
JOHN WILEY & SONS LTD |
| dc.source.none.fl_str_mv |
United European Gastroenterology Journal ISSN: 20506406 ISSNe: 20506414 reponame:r-FISABIO. Repositorio Institucional de Producción Científica instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
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Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| reponame_str |
r-FISABIO. Repositorio Institucional de Producción Científica |
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r-FISABIO. Repositorio Institucional de Producción Científica |
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|
| repository.mail.fl_str_mv |
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1869408396470386688 |
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15,811543 |