The making of leukemia
© 2018 by the authors.
| Autores: | , , , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2018 |
| País: | España |
| Recursos: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositório: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/245401 |
| Acesso em linha: | http://hdl.handle.net/10261/245401 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Leukemia Oncogenes Reprogramming Stem cells Cancer therapy Leukemia stem cell Mouse model |
| id |
ES_56704f4bdabe3aa03d1fd0d8525dd83d |
|---|---|
| oai_identifier_str |
oai:digital.csic.es:10261/245401 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
The making of leukemiaGonzález-Herrero, InésRodríguez-Hernández, GuillermoLuengas-Martínez, AndreaIsidro‑Hernández, MartaJiménez, RafaelGarcía-Cenador, BegoñaGarcía-Criado, Francisco JavierSánchez García, IsidroVicente-Dueñas, CarolinaLeukemiaOncogenesReprogrammingStem cellsCancer therapyLeukemia stem cellMouse model© 2018 by the authors.Due to the clonal nature of human leukemia evolution, all leukemic cells carry the same leukemia-initiating genetic lesions, independently of the intrinsic tumoral cellular heterogeneity. However, the latest findings have shown that the mode of action of oncogenes is not homogeneous throughout the developmental history of leukemia. Studies on different types of hematopoietic tumors have shown that the contribution of oncogenes to leukemia is mainly mediated through the epigenetic reprogramming of the leukemia-initiating target cell. This driving of cancer by a malignant epigenetic stem cell rewiring is, however, not exclusive of the hematopoietic system, but rather represents a common tumoral mechanism that is also at work in epithelial tumors. Tumoral epigenetic reprogramming is therefore a new type of interaction between genes and their target cells, in which the action of the oncogene modifies the epigenome to prime leukemia development by establishing a new pathological tumoral cellular identity. This reprogramming may remain latent until it is triggered by either endogenous or environmental stimuli. This new view on the making of leukemia not only reveals a novel function for oncogenes, but also provides evidence for a previously unconsidered model of leukemogenesis, in which the programming of the leukemia cellular identity has already occurred at the level of stem cells, therefore showing a role for oncogenes in the timing of leukemia initiationWe are indebted to all members of our groups for useful discussions and for their critical reading of the manuscript. Research in C.V.-D. group is partially supported by FEDER, “Miguel Servet” Grant (CP14/00082-AES 2013–2016) from the Instituto de Salud Carlos III (Ministerio de Economía y Competitividad), “Fondo de Investigaciones Sanitarias/Instituto de Salud Carlos III” (PI17/00167) and by the Lady Tata International Award for Research in Leukaemia 2016–2017. Research in I.S.G. group is partially supported by FEDER and by MINECO (SAF2012-32810, SAF2015-64420-R and Red de Excelencia Consolider OncoBIO SAF2014-57791-REDC), and by Junta de Castilla y León (UIC-017, and CSI001U16). I.S.G. lab is a member of the EuroSyStem and the DECIDE Network funded by the European Union under the FP7 program. I.S.G. has been supported by the German Carreras Foundation (DJCLS R13/26).Multidisciplinary Digital Publishing InstituteEuropean CommissionInstituto de Salud Carlos IIIMinisterio de Economía y Competitividad (España)Lady Tata Memorial TrustJunta de Castilla y LeónJosep Carreras Leukemia FoundationConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120182021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/245401reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-64420-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-57791-REDChttp://dx.doi.org/10.3390/ijms19051494Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2454012026-05-22T06:33:51Z |
| dc.title.none.fl_str_mv |
The making of leukemia |
| title |
The making of leukemia |
| spellingShingle |
The making of leukemia González-Herrero, Inés Leukemia Oncogenes Reprogramming Stem cells Cancer therapy Leukemia stem cell Mouse model |
| title_short |
The making of leukemia |
| title_full |
The making of leukemia |
| title_fullStr |
The making of leukemia |
| title_full_unstemmed |
The making of leukemia |
| title_sort |
The making of leukemia |
| dc.creator.none.fl_str_mv |
González-Herrero, Inés Rodríguez-Hernández, Guillermo Luengas-Martínez, Andrea Isidro‑Hernández, Marta Jiménez, Rafael García-Cenador, Begoña García-Criado, Francisco Javier Sánchez García, Isidro Vicente-Dueñas, Carolina |
| author |
González-Herrero, Inés |
| author_facet |
González-Herrero, Inés Rodríguez-Hernández, Guillermo Luengas-Martínez, Andrea Isidro‑Hernández, Marta Jiménez, Rafael García-Cenador, Begoña García-Criado, Francisco Javier Sánchez García, Isidro Vicente-Dueñas, Carolina |
| author_role |
author |
| author2 |
Rodríguez-Hernández, Guillermo Luengas-Martínez, Andrea Isidro‑Hernández, Marta Jiménez, Rafael García-Cenador, Begoña García-Criado, Francisco Javier Sánchez García, Isidro Vicente-Dueñas, Carolina |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
European Commission Instituto de Salud Carlos III Ministerio de Economía y Competitividad (España) Lady Tata Memorial Trust Junta de Castilla y León Josep Carreras Leukemia Foundation Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Leukemia Oncogenes Reprogramming Stem cells Cancer therapy Leukemia stem cell Mouse model |
| topic |
Leukemia Oncogenes Reprogramming Stem cells Cancer therapy Leukemia stem cell Mouse model |
| description |
© 2018 by the authors. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2021 2021 2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_dcae04bc Publisher's version info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/245401 |
| url |
http://hdl.handle.net/10261/245401 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
#PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-64420-R info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-57791-REDC http://dx.doi.org/10.3390/ijms19051494 Sí |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
| publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
| dc.source.none.fl_str_mv |
reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
| instname_str |
Consejo Superior de Investigaciones Científicas (CSIC) |
| reponame_str |
DIGITAL.CSIC. Repositorio Institucional del CSIC |
| collection |
DIGITAL.CSIC. Repositorio Institucional del CSIC |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869408379792785408 |
| score |
15,812429 |