Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinoma

Carcinoma of the urinary bladder is the most common malignancy in many tropical and subtropical countries due to endemic infection by Schistosoma hematobium (bilharzia). In the current study, we performed a high-resolution analysis of gene copy number amplifications using array comparative genomic h...

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Autores: Armengol, Gemma|||0000-0003-2345-1106, Eissa, Saad, Lozano, Juan José, Shoman, Soheir, Sumoy, Lauro|||0000-0003-0005-4618, Caballín, María Rosa|||0000-0002-0091-5484, Knuutila, Sakari
Tipo de documento: artigo
Data de publicação:2007
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:321135
Acesso em linha:https://ddd.uab.cat/record/321135
https://dx.doi.org/urn:doi:10.1016/j.cancergencyto.2007.04.010
Access Level:Acceso aberto
Palavra-chave:SDG 3 - Good Health and Well-being
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spelling Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinomaan array comparative genomic hybridization analysisArmengol, Gemma|||0000-0003-2345-1106Eissa, SaadLozano, Juan JoséShoman, SoheirSumoy, Lauro|||0000-0003-0005-4618Caballín, María Rosa|||0000-0002-0091-5484Knuutila, SakariSDG 3 - Good Health and Well-beingCarcinoma of the urinary bladder is the most common malignancy in many tropical and subtropical countries due to endemic infection by Schistosoma hematobium (bilharzia). In the current study, we performed a high-resolution analysis of gene copy number amplifications using array comparative genomic hybridization to compare DNA copy number changes in pools of Schistosoma-associated (SA) and non-Schistosoma-associated (NSA) bladder cancer (BC). Many DNA copy number changes were detected in all studies, with multiple gains and losses of genetic material. The most frequent alterations were gains on 5p15.2∼p15.33, 8q13.1, and 11q13, and losses on 8p21.3∼p22 and 22q13. Even when SA pools showed no Schistosoma-specific gene copy number profiling as compared to NSA pools, some genes seemed to be gained (ELN on 7q11.23) and some lost (PRKAG3 on 2q35 and PRDM6 on 5q23.2) in SA-SCC. The following genes were gained in all histopathologic categories: SRC (20q11.23), CEBPB (20q13.13), and GPR9 (Xq13.1). Our study did not provide clear evidence of differences in carcinogenesis of SA-BC and NSA-BC. 22007-01-0120072007-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/321135https://dx.doi.org/urn:doi:10.1016/j.cancergencyto.2007.04.010reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3211352026-06-06T12:50:31Z
dc.title.none.fl_str_mv Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinoma
an array comparative genomic hybridization analysis
title Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinoma
spellingShingle Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinoma
Armengol, Gemma|||0000-0003-2345-1106
SDG 3 - Good Health and Well-being
title_short Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinoma
title_full Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinoma
title_fullStr Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinoma
title_full_unstemmed Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinoma
title_sort Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinoma
dc.creator.none.fl_str_mv Armengol, Gemma|||0000-0003-2345-1106
Eissa, Saad
Lozano, Juan José
Shoman, Soheir
Sumoy, Lauro|||0000-0003-0005-4618
Caballín, María Rosa|||0000-0002-0091-5484
Knuutila, Sakari
author Armengol, Gemma|||0000-0003-2345-1106
author_facet Armengol, Gemma|||0000-0003-2345-1106
Eissa, Saad
Lozano, Juan José
Shoman, Soheir
Sumoy, Lauro|||0000-0003-0005-4618
Caballín, María Rosa|||0000-0002-0091-5484
Knuutila, Sakari
author_role author
author2 Eissa, Saad
Lozano, Juan José
Shoman, Soheir
Sumoy, Lauro|||0000-0003-0005-4618
Caballín, María Rosa|||0000-0002-0091-5484
Knuutila, Sakari
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv SDG 3 - Good Health and Well-being
topic SDG 3 - Good Health and Well-being
description Carcinoma of the urinary bladder is the most common malignancy in many tropical and subtropical countries due to endemic infection by Schistosoma hematobium (bilharzia). In the current study, we performed a high-resolution analysis of gene copy number amplifications using array comparative genomic hybridization to compare DNA copy number changes in pools of Schistosoma-associated (SA) and non-Schistosoma-associated (NSA) bladder cancer (BC). Many DNA copy number changes were detected in all studies, with multiple gains and losses of genetic material. The most frequent alterations were gains on 5p15.2∼p15.33, 8q13.1, and 11q13, and losses on 8p21.3∼p22 and 22q13. Even when SA pools showed no Schistosoma-specific gene copy number profiling as compared to NSA pools, some genes seemed to be gained (ELN on 7q11.23) and some lost (PRKAG3 on 2q35 and PRDM6 on 5q23.2) in SA-SCC. The following genes were gained in all histopathologic categories: SRC (20q11.23), CEBPB (20q13.13), and GPR9 (Xq13.1). Our study did not provide clear evidence of differences in carcinogenesis of SA-BC and NSA-BC.
publishDate 2007
dc.date.none.fl_str_mv 2
2007-01-01
2007
2007-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/321135
https://dx.doi.org/urn:doi:10.1016/j.cancergencyto.2007.04.010
url https://ddd.uab.cat/record/321135
https://dx.doi.org/urn:doi:10.1016/j.cancergencyto.2007.04.010
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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