Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria

[EN] The Coronavirus Disease (COVID-19) pandemic is demanding the rapid action of the authorities and scientific community in order to find new antimicrobial solutions that could inactivate the pathogen SARS-CoV-2 that causes this disease. Gram-positive bacteria contribute to severe pneumonia associ...

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Autores: Takayama, Kazuo, Tuñón-Molina, Alberto, Cano-Vicent, Alba, Muramoto, Yukiko, Noda, Takeshi, Martí, Miguel, Serrano-Aroca, Ángel, Aparicio-Collado, José Luís|||0000-0003-0874-9131, Sabater i Serra, Roser|||0000-0002-5550-7066
Tipo de documento: artigo
Data de publicação:2021
País:España
Recursos:Universitat Politècnica de València (UPV)
Repositório:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglês
OAI Identifier:oai:riunet.upv.es:10251/186634
Acesso em linha:https://riunet.upv.es/handle/10251/186634
Access Level:Acceso aberto
Palavra-chave:SARS-CoV-2
Enveloped viruses
Bacteriophage phi 6
Multidrug-resistant
Bacteria
Staphylococcus aureus
Staphylococcus epidermidis
Non-woven fabric
Cranberry extract
Antimicrobial activity
Infection prevention clothing
INGENIERIA ELECTRICA
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oai_identifier_str oai:riunet.upv.es:10251/186634
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria
title Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria
spellingShingle Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria
Takayama, Kazuo
SARS-CoV-2
Enveloped viruses
Bacteriophage phi 6
Multidrug-resistant
Bacteria
Staphylococcus aureus
Staphylococcus epidermidis
Non-woven fabric
Cranberry extract
Antimicrobial activity
Infection prevention clothing
INGENIERIA ELECTRICA
title_short Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria
title_full Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria
title_fullStr Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria
title_full_unstemmed Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria
title_sort Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria
dc.creator.none.fl_str_mv Takayama, Kazuo
Tuñón-Molina, Alberto
Cano-Vicent, Alba
Muramoto, Yukiko
Noda, Takeshi
Martí, Miguel
Serrano-Aroca, Ángel
Aparicio-Collado, José Luís|||0000-0003-0874-9131
Sabater i Serra, Roser|||0000-0002-5550-7066
author Takayama, Kazuo
author_facet Takayama, Kazuo
Tuñón-Molina, Alberto
Cano-Vicent, Alba
Muramoto, Yukiko
Noda, Takeshi
Martí, Miguel
Serrano-Aroca, Ángel
Aparicio-Collado, José Luís|||0000-0003-0874-9131
Sabater i Serra, Roser|||0000-0002-5550-7066
author_role author
author2 Tuñón-Molina, Alberto
Cano-Vicent, Alba
Muramoto, Yukiko
Noda, Takeshi
Martí, Miguel
Serrano-Aroca, Ángel
Aparicio-Collado, José Luís|||0000-0003-0874-9131
Sabater i Serra, Roser|||0000-0002-5550-7066
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial
Departamento de Ingeniería Eléctrica
Centro de Biomateriales e Ingeniería Tisular
Instituto de Salud Carlos III
Agencia Estatal de Investigación
European Regional Development Fund
Japan Science and Technology Agency
Ministerio de Ciencia e Innovación
Japan Agency for Medical Research and Development
Universidad Católica de Valencia San Vicente Mártir
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv SARS-CoV-2
Enveloped viruses
Bacteriophage phi 6
Multidrug-resistant
Bacteria
Staphylococcus aureus
Staphylococcus epidermidis
Non-woven fabric
Cranberry extract
Antimicrobial activity
Infection prevention clothing
INGENIERIA ELECTRICA
topic SARS-CoV-2
Enveloped viruses
Bacteriophage phi 6
Multidrug-resistant
Bacteria
Staphylococcus aureus
Staphylococcus epidermidis
Non-woven fabric
Cranberry extract
Antimicrobial activity
Infection prevention clothing
INGENIERIA ELECTRICA
description [EN] The Coronavirus Disease (COVID-19) pandemic is demanding the rapid action of the authorities and scientific community in order to find new antimicrobial solutions that could inactivate the pathogen SARS-CoV-2 that causes this disease. Gram-positive bacteria contribute to severe pneumonia associated with COVID-19, and their resistance to antibiotics is exponentially increasing. In this regard, non-woven fabrics are currently used for the fabrication of infection prevention clothing such as face masks, caps, scrubs, shirts, trousers, disposable gowns, overalls, hoods, aprons and shoe covers as protective tools against viral and bacterial infections. However, these non-woven fabrics are made of materials that do not exhibit intrinsic antimicrobial activity. Thus, we have here developed non-woven fabrics with antimicrobial coatings of cranberry extracts capable of inactivating enveloped viruses such as SARS-CoV-2 and the bacteriophage phi 6 (about 99% of viral inactivation in 1 min of viral contact), and two multidrug-resistant bacteria: the methicillin-resistant Staphylococcus aureus and the methicillin-resistant Staphylococcus epidermidis. The morphology, thermal and mechanical properties of the produced filters were characterized by optical and electron microscopy, differential scanning calorimetry, thermogravimetry and dynamic mechanical thermal analysis. The non-toxicity of these advanced technologies was ensured using a Caenorhabditis elegans in vivo model. These results open up a new prevention path using natural and biodegradable compounds for the fabrication of infection prevention clothing in the current COVID-19 pandemic and microbial resistant era.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-12-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/186634
url https://riunet.upv.es/handle/10251/186634
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-119333RB-I00 SOPORTES BIOFUNCIONALES CON CAPACIDAD OSTEOINDUCTORA Y ANTIMICROBIANA PARA INGENIERIA TISULAR OSEA
Universidad Católica de Valencia San Vicente Mártir https://doi.org/10.13039/501100015082 2020-231-006UCV
AMED AMED 20fk0108533h0001
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-097862-B-C21 MICROENTORNOS BIOACTIVOS, ELECTROCONDUCTIVOS Y ANTIMICROBIANOS CON CAPACIDAD DE ESTIMULAR LA REGENERACION OSEA Y PREVENIR INFECCIONES MULTIRRESISTENTES
Japan Science and Technology Agency https://doi.org/10.13039/501100002241 JPMJCR20HA
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant BacteriaTakayama, KazuoTuñón-Molina, AlbertoCano-Vicent, AlbaMuramoto, YukikoNoda, TakeshiMartí, MiguelSerrano-Aroca, ÁngelAparicio-Collado, José Luís|||0000-0003-0874-9131Sabater i Serra, Roser|||0000-0002-5550-7066SARS-CoV-2Enveloped virusesBacteriophage phi 6Multidrug-resistantBacteriaStaphylococcus aureusStaphylococcus epidermidisNon-woven fabricCranberry extractAntimicrobial activityInfection prevention clothingINGENIERIA ELECTRICA[EN] The Coronavirus Disease (COVID-19) pandemic is demanding the rapid action of the authorities and scientific community in order to find new antimicrobial solutions that could inactivate the pathogen SARS-CoV-2 that causes this disease. Gram-positive bacteria contribute to severe pneumonia associated with COVID-19, and their resistance to antibiotics is exponentially increasing. In this regard, non-woven fabrics are currently used for the fabrication of infection prevention clothing such as face masks, caps, scrubs, shirts, trousers, disposable gowns, overalls, hoods, aprons and shoe covers as protective tools against viral and bacterial infections. However, these non-woven fabrics are made of materials that do not exhibit intrinsic antimicrobial activity. Thus, we have here developed non-woven fabrics with antimicrobial coatings of cranberry extracts capable of inactivating enveloped viruses such as SARS-CoV-2 and the bacteriophage phi 6 (about 99% of viral inactivation in 1 min of viral contact), and two multidrug-resistant bacteria: the methicillin-resistant Staphylococcus aureus and the methicillin-resistant Staphylococcus epidermidis. The morphology, thermal and mechanical properties of the produced filters were characterized by optical and electron microscopy, differential scanning calorimetry, thermogravimetry and dynamic mechanical thermal analysis. The non-toxicity of these advanced technologies was ensured using a Caenorhabditis elegans in vivo model. These results open up a new prevention path using natural and biodegradable compounds for the fabrication of infection prevention clothing in the current COVID-19 pandemic and microbial resistant era.This research was supported by the Fundacion Universidad Catolica de Valencia San VicenteMartir, Grant 2020-231-006UCV and by the Ministerio de Ciencia e Innovacion: project PID2020-119333RB-I00/AEI/10.13039/501100011033 (awarded to A.S.-A.) and project RTI2018-097862-B-C21 (awarded to R.S.i.S. including FEDER funding). CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program. CIBER Actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. This research was also supported by grants from the Japan Agency for Medical Research and Development (AMED) (20fk0108533h0001), and the JST Core Research for Evolutional Science and Technology (JPMJCR20HA). This work was supported by the Joint Usage/Research Center program of Institute for Frontier Life and Medical Sciences Kyoto University.MDPI AGEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialDepartamento de Ingeniería EléctricaCentro de Biomateriales e Ingeniería TisularInstituto de Salud Carlos IIIAgencia Estatal de InvestigaciónEuropean Regional Development FundJapan Science and Technology AgencyMinisterio de Ciencia e InnovaciónJapan Agency for Medical Research and DevelopmentUniversidad Católica de Valencia San Vicente MártirRepositorio Institucional de la Universitat Politècnica de València Riunet20212021-12-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/186634reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-119333RB-I00 SOPORTES BIOFUNCIONALES CON CAPACIDAD OSTEOINDUCTORA Y ANTIMICROBIANA PARA INGENIERIA TISULAR OSEAUniversidad Católica de Valencia San Vicente Mártir https://doi.org/10.13039/501100015082 2020-231-006UCVAMED AMED 20fk0108533h0001Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-097862-B-C21 MICROENTORNOS BIOACTIVOS, ELECTROCONDUCTIVOS Y ANTIMICROBIANOS CON CAPACIDAD DE ESTIMULAR LA REGENERACION OSEA Y PREVENIR INFECCIONES MULTIRRESISTENTESJapan Science and Technology Agency https://doi.org/10.13039/501100002241 JPMJCR20HAopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1866342026-06-13T07:49:27Z
score 15,300719

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