Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium
DNA methylation; Epigenetics; Sleep
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/13164 |
| Acceso en línea: | http://hdl.handle.net/11351/13164 |
| Access Level: | acceso abierto |
| Palabra clave: | Embaràs Infants Genòmica ADN - Metilació Infants - Desenvolupament PSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Human Development::Child Development DISCIPLINES AND OCCUPATIONS::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Genomics::Epigenomics PHENOMENA AND PROCESSES::Chemical Phenomena::Biochemical Phenomena::Alkylation::Methylation::DNA Methylation PHENOMENA AND PROCESSES::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproduction::Pregnancy PSIQUIATRÍA Y PSICOLOGÍA::conducta y mecanismos de la conducta::desarrollo humano::desarrollo del niño DISCIPLINAS Y OCUPACIONES::disciplinas de las ciencias naturales::disciplinas de las ciencias biológicas::biología::biología computacional::genómica::epigenómica FENÓMENOS Y PROCESOS::fenómenos químicos::fenómenos bioquímicos::alquilación::metilación::metilación del ADN FENÓMENOS Y PROCESOS::fenómenos fisiológicos reproductivos y urinarios::fenómenos fisiológicos de la reproducción::reproducción::embarazo |
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Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium |
| title |
Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium |
| spellingShingle |
Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium Neumann, Alexander Embaràs Infants Genòmica ADN - Metilació Infants - Desenvolupament PSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Human Development::Child Development DISCIPLINES AND OCCUPATIONS::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Genomics::Epigenomics PHENOMENA AND PROCESSES::Chemical Phenomena::Biochemical Phenomena::Alkylation::Methylation::DNA Methylation PHENOMENA AND PROCESSES::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproduction::Pregnancy PSIQUIATRÍA Y PSICOLOGÍA::conducta y mecanismos de la conducta::desarrollo humano::desarrollo del niño DISCIPLINAS Y OCUPACIONES::disciplinas de las ciencias naturales::disciplinas de las ciencias biológicas::biología::biología computacional::genómica::epigenómica FENÓMENOS Y PROCESOS::fenómenos químicos::fenómenos bioquímicos::alquilación::metilación::metilación del ADN FENÓMENOS Y PROCESOS::fenómenos fisiológicos reproductivos y urinarios::fenómenos fisiológicos de la reproducción::reproducción::embarazo |
| title_short |
Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium |
| title_full |
Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium |
| title_fullStr |
Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium |
| title_full_unstemmed |
Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium |
| title_sort |
Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium |
| dc.creator.none.fl_str_mv |
Neumann, Alexander Sammallahti, Sara Cosín-Tomàs, Marta Reese, Sarah Suderman, Matthew Alemany, Silvia |
| author |
Neumann, Alexander |
| author_facet |
Neumann, Alexander Sammallahti, Sara Cosín-Tomàs, Marta Reese, Sarah Suderman, Matthew Alemany, Silvia |
| author_role |
author |
| author2 |
Sammallahti, Sara Cosín-Tomàs, Marta Reese, Sarah Suderman, Matthew Alemany, Silvia |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Neumann A] Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands. [Sammallahti S] Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland. Helsinki University Hospital, Helsinki, Finland. [Cosin Tomas M] ISGlobal, Barcelona, Spain. Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública, Madrid, Spain. [Reese SE] Clinical Research Practice, Westat, Rockville, MD, USA. [Suderman M] Bristol Medical School, Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK. [Alemany S] Grup de Recerca de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Biomedical Network Research Centre on Mental Health (CIBERSAM), Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Embaràs Infants Genòmica ADN - Metilació Infants - Desenvolupament PSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Human Development::Child Development DISCIPLINES AND OCCUPATIONS::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Genomics::Epigenomics PHENOMENA AND PROCESSES::Chemical Phenomena::Biochemical Phenomena::Alkylation::Methylation::DNA Methylation PHENOMENA AND PROCESSES::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproduction::Pregnancy PSIQUIATRÍA Y PSICOLOGÍA::conducta y mecanismos de la conducta::desarrollo humano::desarrollo del niño DISCIPLINAS Y OCUPACIONES::disciplinas de las ciencias naturales::disciplinas de las ciencias biológicas::biología::biología computacional::genómica::epigenómica FENÓMENOS Y PROCESOS::fenómenos químicos::fenómenos bioquímicos::alquilación::metilación::metilación del ADN FENÓMENOS Y PROCESOS::fenómenos fisiológicos reproductivos y urinarios::fenómenos fisiológicos de la reproducción::reproducción::embarazo |
| topic |
Embaràs Infants Genòmica ADN - Metilació Infants - Desenvolupament PSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Human Development::Child Development DISCIPLINES AND OCCUPATIONS::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Genomics::Epigenomics PHENOMENA AND PROCESSES::Chemical Phenomena::Biochemical Phenomena::Alkylation::Methylation::DNA Methylation PHENOMENA AND PROCESSES::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproduction::Pregnancy PSIQUIATRÍA Y PSICOLOGÍA::conducta y mecanismos de la conducta::desarrollo humano::desarrollo del niño DISCIPLINAS Y OCUPACIONES::disciplinas de las ciencias naturales::disciplinas de las ciencias biológicas::biología::biología computacional::genómica::epigenómica FENÓMENOS Y PROCESOS::fenómenos químicos::fenómenos bioquímicos::alquilación::metilación::metilación del ADN FENÓMENOS Y PROCESOS::fenómenos fisiológicos reproductivos y urinarios::fenómenos fisiológicos de la reproducción::reproducción::embarazo |
| description |
DNA methylation; Epigenetics; Sleep |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2025 2025 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11351/13164 |
| url |
http://hdl.handle.net/11351/13164 |
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Inglés |
| language_invalid_str_mv |
Inglés |
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Genome Medicine;17 https://doi.org/10.1186/s13073-025-01451-7 info:eu-repo/grantAgreement/EC/H2020/848158 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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BMC |
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BMC |
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Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
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Departament de Salut de la Generalitat de Catalunya (DS) |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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| _version_ |
1869408346178584576 |
| spelling |
Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics ConsortiumNeumann, AlexanderSammallahti, SaraCosín-Tomàs, MartaReese, SarahSuderman, MatthewAlemany, SilviaEmbaràsInfantsGenòmicaADN - MetilacióInfants - DesenvolupamentPSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Human Development::Child DevelopmentDISCIPLINES AND OCCUPATIONS::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Genomics::EpigenomicsPHENOMENA AND PROCESSES::Chemical Phenomena::Biochemical Phenomena::Alkylation::Methylation::DNA MethylationPHENOMENA AND PROCESSES::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproduction::PregnancyPSIQUIATRÍA Y PSICOLOGÍA::conducta y mecanismos de la conducta::desarrollo humano::desarrollo del niñoDISCIPLINAS Y OCUPACIONES::disciplinas de las ciencias naturales::disciplinas de las ciencias biológicas::biología::biología computacional::genómica::epigenómicaFENÓMENOS Y PROCESOS::fenómenos químicos::fenómenos bioquímicos::alquilación::metilación::metilación del ADNFENÓMENOS Y PROCESOS::fenómenos fisiológicos reproductivos y urinarios::fenómenos fisiológicos de la reproducción::reproducción::embarazoDNA methylation; Epigenetics; SleepEpigenètica; Pediatria; SonEpigenética; Pediatría; SueñoBackground DNA methylation (DNAm) is a developmentally dynamic epigenetic process; yet, most epigenome-wide association studies (EWAS) have examined DNAm at only one timepoint or without systematic comparisons between timepoints. Thus, it is unclear whether DNAm alterations during certain developmental periods are more informative than others for health outcomes, how persistent epigenetic signals are across time, and whether epigenetic timing effects differ by outcome. Methods We applied longitudinal meta-regression models to published meta-analyses from the PACE consortium that examined DNAm at two timepoints—prospectively at birth and cross-sectionally in childhood—in relation to the same child outcome (ADHD symptoms, general psychopathology, sleep duration, BMI, asthma). These models allowed systematic comparisons of effect sizes and statistical significance between timepoints. Furthermore, we tested correlations between DNAm regression coefficients to assess the consistency of epigenetic signals across time and outcomes. Finally, we performed robustness checks, estimated between-study heterogeneity, and tested pathway enrichment. Results Our findings reveal three new insights: (i) across outcomes, DNAm effect sizes are consistently larger in childhood cross-sectional analyses compared to prospective analyses at birth; (ii) higher effect sizes do not necessarily translate into more significant findings, as associations also become noisier in childhood for most outcomes (showing larger standard errors in cross-sectional vs prospective analyses); and (iii) DNAm signals are highly time-specific, while also showing evidence of shared associations across health outcomes (ADHD symptoms, general psychopathology, and asthma). Notably, these observations could not be explained by sample size differences and only partly to differential study-heterogeneity. DNAm sites changing associations were enriched for neural pathways. Conclusions Our results highlight developmentally-specific associations between DNAm and child health outcomes, when assessing DNAm at birth vs childhood. This implies that EWAS results from one timepoint are unlikely to generalize to another. Longitudinal studies with repeated epigenetic assessments are direly needed to shed light on the dynamic relationship between DNAm, development and health, as well as to enable the creation of more reliable and generalizable epigenetic biomarkers. More broadly, this study underscores the importance of considering the time-varying nature of DNAm in epigenetic research and supports the potential existence of epigenetic “timing effects” on child health.The work of AN and CAMC was supported by the European Research Council (TEMPO; grant agreement No 101039672) and the European Union’s HorizonEurope Research and Innovation Programme (FAMILY, grant agreement No 101057529). The work of CAMC is further supported by the European Union’s Horizon 2020 Research and Innovation Programme (EarlyCause, grant agreement No 848158; HappyMums, grant agreement No 101057390). CAMC and JFF are supported by the European Union’s Horizon Europe Programme (STAGE project, grant agreement no.101137146). This research was conducted while CAMC was a Hevolution/AFAR New Investigator Awardee in Aging Biology and Geroscience Research. LST was supported by the CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) project, the European Union’s Horizon 2020 research and innovation program, Marie Sklodowska Curie Actions – MSCA-ITN-2016 – Innovative Training Networks under grant agreement number 721567. SJL was supported in part by the Intramural Research Program of the NIH (NIEHS Z01 ES49019). SEH and CMP were partly supported by The Norwegian Research Council no 262700 and the Norwegian Cancer Society project no 244291. See additional file 3 for cohort-specific funding.BMCInstitut Català de la Salut[Neumann A] Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands. [Sammallahti S] Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland. Helsinki University Hospital, Helsinki, Finland. [Cosin Tomas M] ISGlobal, Barcelona, Spain. Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública, Madrid, Spain. [Reese SE] Clinical Research Practice, Westat, Rockville, MD, USA. [Suderman M] Bristol Medical School, Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK. [Alemany S] Grup de Recerca de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Biomedical Network Research Centre on Mental Health (CIBERSAM), Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, SpainVall d'Hebron Barcelona Hospital Campus202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/11351/13164Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésGenome Medicine;17https://doi.org/10.1186/s13073-025-01451-7info:eu-repo/grantAgreement/EC/H2020/848158Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/131642026-06-12T09:38:37Z |
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15,81155 |