Immune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium

Monitoring; Myelodysplastic neoplasms; Recommendations

Detalles Bibliográficos
Autores: Tentori, Cristina A., Zhao, Lin P., Tinterri, Benedetta, Strange, Kathryn, Zoldan, Katharina, Dimopoulos, Konstantinos, Gallur, Laura, VALCARCEL, DAVID
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/11512
Acceso en línea:https://hdl.handle.net/11351/11512
Access Level:acceso abierto
Palabra clave:Síndromes mielodisplàsiques
Immunologia
Monitoratge de pacients
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Immunologic Tests::Monitoring, Immunologic
DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases::Bone Marrow Diseases::Myelodysplastic Syndromes
Other subheadings::Other subheadings::Other subheadings::/immunology
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::pruebas inmunológicas::monitorización inmunitaria
ENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades hematológicas::enfermedades de la médula ósea::síndromes mielodisplásicos
Otros calificadores::Otros calificadores::Otros calificadores::/inmunología
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repository_id_str
dc.title.none.fl_str_mv Immune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium
title Immune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium
spellingShingle Immune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium
Tentori, Cristina A.
Síndromes mielodisplàsiques
Immunologia
Monitoratge de pacients
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Immunologic Tests::Monitoring, Immunologic
DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases::Bone Marrow Diseases::Myelodysplastic Syndromes
Other subheadings::Other subheadings::Other subheadings::/immunology
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::pruebas inmunológicas::monitorización inmunitaria
ENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades hematológicas::enfermedades de la médula ósea::síndromes mielodisplásicos
Otros calificadores::Otros calificadores::Otros calificadores::/inmunología
title_short Immune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium
title_full Immune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium
title_fullStr Immune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium
title_full_unstemmed Immune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium
title_sort Immune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium
dc.creator.none.fl_str_mv Tentori, Cristina A.
Zhao, Lin P.
Tinterri, Benedetta
Strange, Kathryn
Zoldan, Katharina
Dimopoulos, Konstantinos
Gallur, Laura
VALCARCEL, DAVID
author Tentori, Cristina A.
author_facet Tentori, Cristina A.
Zhao, Lin P.
Tinterri, Benedetta
Strange, Kathryn
Zoldan, Katharina
Dimopoulos, Konstantinos
Gallur, Laura
VALCARCEL, DAVID
author_role author
author2 Zhao, Lin P.
Tinterri, Benedetta
Strange, Kathryn
Zoldan, Katharina
Dimopoulos, Konstantinos
Gallur, Laura
VALCARCEL, DAVID
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Tentori CA] Humanitas Clinical and Research Center–IRCCS & Department of Biomedical Sciences, Humanitas University, Milan, Italy. Comprehensive Cancer Centre, King's College, London, UK. [Zhao LP] Hématologie seniors, Hôpital Saint‐Louis, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France. INSERM UMR_S1160, Institut de Recherche Saint Louis, Université Paris Cité, Paris, France. [Tinterri B] Humanitas Clinical and Research Center–IRCCS & Department of Biomedical Sciences, Humanitas University, Milan, Italy. [Strange KE] Comprehensive Cancer Centre, King's College, London, UK. Research Group of Molecular Immunology, Francis Crick Institute, London, UK. [Zoldan K] Department of Medicine 1, Haematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Medical Center Leipzig, Leipzig, Germany. [Dimopoulos K] Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. [Gallur L, Valcarcel D] Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut of Oncology (VHIO), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Síndromes mielodisplàsiques
Immunologia
Monitoratge de pacients
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Immunologic Tests::Monitoring, Immunologic
DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases::Bone Marrow Diseases::Myelodysplastic Syndromes
Other subheadings::Other subheadings::Other subheadings::/immunology
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::pruebas inmunológicas::monitorización inmunitaria
ENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades hematológicas::enfermedades de la médula ósea::síndromes mielodisplásicos
Otros calificadores::Otros calificadores::Otros calificadores::/inmunología
topic Síndromes mielodisplàsiques
Immunologia
Monitoratge de pacients
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Immunologic Tests::Monitoring, Immunologic
DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases::Bone Marrow Diseases::Myelodysplastic Syndromes
Other subheadings::Other subheadings::Other subheadings::/immunology
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::pruebas inmunológicas::monitorización inmunitaria
ENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades hematológicas::enfermedades de la médula ósea::síndromes mielodisplásicos
Otros calificadores::Otros calificadores::Otros calificadores::/inmunología
description Monitoring; Myelodysplastic neoplasms; Recommendations
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/11512
url https://hdl.handle.net/11351/11512
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv HemaSphere;8(5)
https://doi.org/10.1002/hem3.64
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408345716162560
spelling Immune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortiumTentori, Cristina A.Zhao, Lin P.Tinterri, BenedettaStrange, KathrynZoldan, KatharinaDimopoulos, KonstantinosGallur, LauraVALCARCEL, DAVIDSíndromes mielodisplàsiquesImmunologiaMonitoratge de pacientsANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Immunologic Tests::Monitoring, ImmunologicDISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases::Bone Marrow Diseases::Myelodysplastic SyndromesOther subheadings::Other subheadings::Other subheadings::/immunologyTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::pruebas inmunológicas::monitorización inmunitariaENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades hematológicas::enfermedades de la médula ósea::síndromes mielodisplásicosOtros calificadores::Otros calificadores::Otros calificadores::/inmunologíaMonitoring; Myelodysplastic neoplasms; RecommendationsMonitorización; Neoplasias mielodisplásicas; RecomendacionesMonitorització; Neoplàsies mielodisplàstiques; RecomanacionsAdvancements in comprehending myelodysplastic neoplasms (MDS) have unfolded significantly in recent years, elucidating a myriad of cellular and molecular underpinnings integral to disease progression. While molecular inclusions into prognostic models have substantively advanced risk stratification, recent revelations have emphasized the pivotal role of immune dysregulation within the bone marrow milieu during MDS evolution. Nonetheless, immunotherapy for MDS has not experienced breakthroughs seen in other malignancies, partly attributable to the absence of an immune classification that could stratify patients toward optimally targeted immunotherapeutic approaches. A pivotal obstacle to establishing “immune classes” among MDS patients is the absence of validated accepted immune panels suitable for routine application in clinical laboratories. In response, we formed International Integrative Innovative Immunology for MDS (i4MDS), a consortium of multidisciplinary experts, and created the following recommendations for standardized methodologies to monitor immune responses in MDS. A central goal of i4MDS is the development of an immune score that could be incorporated into current clinical risk stratification models. This position paper first consolidates current knowledge on MDS immunology. Subsequently, in collaboration with clinical and laboratory specialists, we introduce flow cytometry panels and cytokine assays, meticulously devised for clinical laboratories, aiming to monitor the immune status of MDS patients, evaluating both immune fitness and identifying potential immune “risk factors.” By amalgamating this immunological characterization data and molecular data, we aim to enhance patient stratification, identify predictive markers for treatment responsiveness, and accelerate the development of systems immunology tools and innovative immunotherapies.This work was supported by the CRUK City of London Centre Award [CTRQQR-2021/100004] at KCL. C. A. T. is supported by SIE—Società Italiana di Ematologia and the Association “Amici di Beat Leukemia Dr. Alessandro Cevenini ONLUS” (www.beat-leukemia.org). M. G. D. P. is supported by European Union-Next Generation EU-NRRP M6C2 (Investment 2.1 Enhancement and strengthening of biomedical research in the NHS—Project PNRR-MAD-2022-12376695); AIRC Foundation (Associazione Italiana per la Ricerca contro il Cancro, Milan Italy—Project #22053); 5 × 1000 MYNERVA (Myeloid Neoplasms Research Venture AIRC-project #21267). V. S. is supported by AIRC project IG 26537-2021.WileyInstitut Català de la Salut[Tentori CA] Humanitas Clinical and Research Center–IRCCS & Department of Biomedical Sciences, Humanitas University, Milan, Italy. Comprehensive Cancer Centre, King's College, London, UK. [Zhao LP] Hématologie seniors, Hôpital Saint‐Louis, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France. INSERM UMR_S1160, Institut de Recherche Saint Louis, Université Paris Cité, Paris, France. [Tinterri B] Humanitas Clinical and Research Center–IRCCS & Department of Biomedical Sciences, Humanitas University, Milan, Italy. [Strange KE] Comprehensive Cancer Centre, King's College, London, UK. Research Group of Molecular Immunology, Francis Crick Institute, London, UK. [Zoldan K] Department of Medicine 1, Haematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Medical Center Leipzig, Leipzig, Germany. [Dimopoulos K] Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. [Gallur L, Valcarcel D] Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut of Oncology (VHIO), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/11512Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésHemaSphere;8(5)https://doi.org/10.1002/hem3.64Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/115122026-06-12T09:38:37Z
score 15,812429

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