Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania

OBJECTIVES: The epidemiological and clinical determinants of hepatitis delta virus (HDV) infection in Sub-Saharan Africa are ill-defined. The prevalence of HDV infection was determined in HIV/hepatitis B virus (HBV) co-infected individuals in rural Tanzania. METHODS: All hepatitis B virus (HBV)-infe...

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Autores: Winter, Annja, Letang, Emilio, Kalinjuma, Aneth Vedastus, Kimera, Namvua, Ntamatungiro, Alex J., Glass, Tracy R., Moradpour, Darius, Sahli, Roland, Le Gal, Frédéric, Furrer, Hansjakob, Wandeler, Gilles, KIULARCO Study Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/98687
Acceso en línea:https://hdl.handle.net/2445/98687
Access Level:acceso abierto
Palabra clave:VIH (Virus)
Virus de l'hepatitis delta
HIV (Viruses)
Hepatitis D (hepatitis delta)
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spelling Absence of hepatitis delta infection in a large rural HIV cohort in TanzaniaWinter, AnnjaLetang, EmilioKalinjuma, Aneth VedastusKimera, NamvuaNtamatungiro, Alex J.Glass, Tracy R.Moradpour, DariusSahli, RolandLe Gal, FrédéricFurrer, HansjakobWandeler, GillesKIULARCO Study GroupVIH (Virus)Virus de l'hepatitis deltaHIV (Viruses)Hepatitis D (hepatitis delta)OBJECTIVES: The epidemiological and clinical determinants of hepatitis delta virus (HDV) infection in Sub-Saharan Africa are ill-defined. The prevalence of HDV infection was determined in HIV/hepatitis B virus (HBV) co-infected individuals in rural Tanzania. METHODS: All hepatitis B virus (HBV)-infected adults under active follow-up in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) were screened for anti-HDV antibodies. For positive samples, a second serological test and nucleic acid amplification were performed. Demographic and clinical characteristics at initiation of antiretroviral therapy (ART) were compared between anti-HDV-negative and positive patients. RESULTS: Among 222 HIV/HBV co-infected patients on ART, 219 (98.6%) had a stored serum sample available and were included in the study. Median age was 37 years, 55% were female, 46% had World Health Organization stage III/IV HIV disease, and the median CD4 count was 179 cells/mul. The prevalence of anti-HDV positivity was 5.0% (95% confidence interval 2.8-8.9%). There was no significant predictor of anti-HDV positivity. HDV could not be amplified in any of the anti-HDV-positive patients and the second serological test was negative in all of them. CONCLUSIONS: No confirmed case of HDV infection was found among over 200 HIV/HBV co-infected patients in Tanzania. As false-positive serology results are common, screening results should be confirmed with a second test.Elsevier Inc.2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/98687Articles publicats en revistes (ISGlobal)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1016/j.ijid.2016.03.011International Journal of Infectious Diseases, 2016, vol. 46, p. 8-10http://dx.doi.org/10.1016/j.ijid.2016.03.011cc by-nc-nd (c) Winter et al., 2016http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/986872026-05-27T06:46:51Z
dc.title.none.fl_str_mv Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania
title Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania
spellingShingle Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania
Winter, Annja
VIH (Virus)
Virus de l'hepatitis delta
HIV (Viruses)
Hepatitis D (hepatitis delta)
title_short Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania
title_full Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania
title_fullStr Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania
title_full_unstemmed Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania
title_sort Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania
dc.creator.none.fl_str_mv Winter, Annja
Letang, Emilio
Kalinjuma, Aneth Vedastus
Kimera, Namvua
Ntamatungiro, Alex J.
Glass, Tracy R.
Moradpour, Darius
Sahli, Roland
Le Gal, Frédéric
Furrer, Hansjakob
Wandeler, Gilles
KIULARCO Study Group
author Winter, Annja
author_facet Winter, Annja
Letang, Emilio
Kalinjuma, Aneth Vedastus
Kimera, Namvua
Ntamatungiro, Alex J.
Glass, Tracy R.
Moradpour, Darius
Sahli, Roland
Le Gal, Frédéric
Furrer, Hansjakob
Wandeler, Gilles
KIULARCO Study Group
author_role author
author2 Letang, Emilio
Kalinjuma, Aneth Vedastus
Kimera, Namvua
Ntamatungiro, Alex J.
Glass, Tracy R.
Moradpour, Darius
Sahli, Roland
Le Gal, Frédéric
Furrer, Hansjakob
Wandeler, Gilles
KIULARCO Study Group
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv VIH (Virus)
Virus de l'hepatitis delta
HIV (Viruses)
Hepatitis D (hepatitis delta)
topic VIH (Virus)
Virus de l'hepatitis delta
HIV (Viruses)
Hepatitis D (hepatitis delta)
description OBJECTIVES: The epidemiological and clinical determinants of hepatitis delta virus (HDV) infection in Sub-Saharan Africa are ill-defined. The prevalence of HDV infection was determined in HIV/hepatitis B virus (HBV) co-infected individuals in rural Tanzania. METHODS: All hepatitis B virus (HBV)-infected adults under active follow-up in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) were screened for anti-HDV antibodies. For positive samples, a second serological test and nucleic acid amplification were performed. Demographic and clinical characteristics at initiation of antiretroviral therapy (ART) were compared between anti-HDV-negative and positive patients. RESULTS: Among 222 HIV/HBV co-infected patients on ART, 219 (98.6%) had a stored serum sample available and were included in the study. Median age was 37 years, 55% were female, 46% had World Health Organization stage III/IV HIV disease, and the median CD4 count was 179 cells/mul. The prevalence of anti-HDV positivity was 5.0% (95% confidence interval 2.8-8.9%). There was no significant predictor of anti-HDV positivity. HDV could not be amplified in any of the anti-HDV-positive patients and the second serological test was negative in all of them. CONCLUSIONS: No confirmed case of HDV infection was found among over 200 HIV/HBV co-infected patients in Tanzania. As false-positive serology results are common, screening results should be confirmed with a second test.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/98687
url https://hdl.handle.net/2445/98687
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1016/j.ijid.2016.03.011
International Journal of Infectious Diseases, 2016, vol. 46, p. 8-10
http://dx.doi.org/10.1016/j.ijid.2016.03.011
dc.rights.none.fl_str_mv cc by-nc-nd (c) Winter et al., 2016
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Winter et al., 2016
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc.
publisher.none.fl_str_mv Elsevier Inc.
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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