Cross-species transcriptomics uncovers genes underlying genetic accommodation of developmental plasticity in spadefoot toads

14 p.

Detalhes bibliográficos
Autores: Liedtke, H. Christoph, Harney, Ewan, Gómez-Mestre, Iván
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/267096
Acesso em linha:http://hdl.handle.net/10261/267096
https://api.elsevier.com/content/abstract/scopus_id/85103987804
Access Level:acceso abierto
Palavra-chave:Pelobates cultripes
Scaphiopus couchii
RNA-Seq
WGCNA
network analysis
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spelling Cross-species transcriptomics uncovers genes underlying genetic accommodation of developmental plasticity in spadefoot toadsLiedtke, H. ChristophHarney, EwanGómez-Mestre, IvánPelobates cultripesScaphiopus couchiiRNA-SeqWGCNAnetwork analysis14 p.That hardcoded genomes can manifest as plastic phenotypes responding to environmental perturbations is a fascinating feature of living organisms. How such developmental plasticity is regulated at the molecular level is beginning to be uncovered aided by the development of -omic techniques. Here, we compare the transcriptome-wide responses of two species of spadefoot toads with differing capacity for developmental acceleration of their larvae in the face of a shared environmental risk: pond drying. By comparing gene expression profiles over time and performing cross-species network analyses, we identified orthologues and functional gene pathways whose environmental sensitivity in expression have diverged between species. Genes related to lipid, cholesterol and steroid biosynthesis and metabolism make up most of a module of genes environmentally responsive in one species, but canalized in the other. The evolutionary changes in the regulation of the genes identified through these analyses may have been key in the genetic accommodation of developmental plasticity in this system.Ministerio de Economía, Industria y Competitividad (MINECO), Grant/Award Number: CGL2017-83407-PPeer reviewedJohn Wiley & SonsMinisterio de Economía, Industria y Competitividad (España)Gómez-Mestre, Iván [0000-0003-0094-8195]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/267096https://api.elsevier.com/content/abstract/scopus_id/85103987804reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CGL2017-83407-Phttps://doi.org/10.1111/mec.15883Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2670962026-05-22T06:33:51Z
dc.title.none.fl_str_mv Cross-species transcriptomics uncovers genes underlying genetic accommodation of developmental plasticity in spadefoot toads
title Cross-species transcriptomics uncovers genes underlying genetic accommodation of developmental plasticity in spadefoot toads
spellingShingle Cross-species transcriptomics uncovers genes underlying genetic accommodation of developmental plasticity in spadefoot toads
Liedtke, H. Christoph
Pelobates cultripes
Scaphiopus couchii
RNA-Seq
WGCNA
network analysis
title_short Cross-species transcriptomics uncovers genes underlying genetic accommodation of developmental plasticity in spadefoot toads
title_full Cross-species transcriptomics uncovers genes underlying genetic accommodation of developmental plasticity in spadefoot toads
title_fullStr Cross-species transcriptomics uncovers genes underlying genetic accommodation of developmental plasticity in spadefoot toads
title_full_unstemmed Cross-species transcriptomics uncovers genes underlying genetic accommodation of developmental plasticity in spadefoot toads
title_sort Cross-species transcriptomics uncovers genes underlying genetic accommodation of developmental plasticity in spadefoot toads
dc.creator.none.fl_str_mv Liedtke, H. Christoph
Harney, Ewan
Gómez-Mestre, Iván
author Liedtke, H. Christoph
author_facet Liedtke, H. Christoph
Harney, Ewan
Gómez-Mestre, Iván
author_role author
author2 Harney, Ewan
Gómez-Mestre, Iván
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Economía, Industria y Competitividad (España)
Gómez-Mestre, Iván [0000-0003-0094-8195]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Pelobates cultripes
Scaphiopus couchii
RNA-Seq
WGCNA
network analysis
topic Pelobates cultripes
Scaphiopus couchii
RNA-Seq
WGCNA
network analysis
description 14 p.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/267096
https://api.elsevier.com/content/abstract/scopus_id/85103987804
url http://hdl.handle.net/10261/267096
https://api.elsevier.com/content/abstract/scopus_id/85103987804
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CGL2017-83407-P
https://doi.org/10.1111/mec.15883
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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