Novel mechanism for oscillations in catchbonded motor-filament complexes

Generation of mechanical oscillations is ubiquitous to a wide variety of intracellular processes, ranging from activity of muscle fibers to oscillations of the mitotic spindle. The activity of motors plays a vital role in maintaining the integrity of the mitotic spindle structure and generating spon...

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Detalhes bibliográficos
Autores: Guha, Sougata, Mitra, Mithun K., Pagonabarraga Mora, Ignacio, Muhuri, Sudipto
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/184772
Acesso em linha:https://hdl.handle.net/2445/184772
Access Level:acceso abierto
Palavra-chave:Oscil·lacions
Citosquelet
Microtúbuls
Oscillations
Cytoskeleton
Microtubules
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oai_identifier_str oai:diposit.ub.edu:2445/184772
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repository_id_str
spelling Novel mechanism for oscillations in catchbonded motor-filament complexesGuha, SougataMitra, Mithun K.Pagonabarraga Mora, IgnacioMuhuri, SudiptoOscil·lacionsCitosqueletMicrotúbulsOscillationsCytoskeletonMicrotubulesGeneration of mechanical oscillations is ubiquitous to a wide variety of intracellular processes, ranging from activity of muscle fibers to oscillations of the mitotic spindle. The activity of motors plays a vital role in maintaining the integrity of the mitotic spindle structure and generating spontaneous oscillations. Although the structural features and properties of the individual motors are well characterized, their implications on the functional behavior of motor-filament complexes are more involved. We show that force-induced allosteric deformations in dynein, which result in catchbonding behavior, provide a generic mechanism to generate spontaneous oscillations in motor-cytoskeletal filament complexes. The resultant phase diagram of such motor-filament systems¿characterized by force-induced allosteric deformations¿exhibits bistability and sustained limit-cycle oscillations in biologically relevant regimes, such as for catchbonded dynein. The results reported here elucidate the central role of this mechanism in fashioning a distinctive stability behavior and oscillations in motor-filament complexes such as mitotic spindles.Biophysical Society2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/184772Articles publicats en revistes (Física de la Matèria Condensada)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1016/j.bpj.2021.07.018Biophysical Journal, 2021, vol. 120, num. 18, p. 4129https://doi.org/10.1016/j.bpj.2021.07.018cc-by-nc-nd (c) Biophysical Society, 2021https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1847722026-05-27T06:46:51Z
dc.title.none.fl_str_mv Novel mechanism for oscillations in catchbonded motor-filament complexes
title Novel mechanism for oscillations in catchbonded motor-filament complexes
spellingShingle Novel mechanism for oscillations in catchbonded motor-filament complexes
Guha, Sougata
Oscil·lacions
Citosquelet
Microtúbuls
Oscillations
Cytoskeleton
Microtubules
title_short Novel mechanism for oscillations in catchbonded motor-filament complexes
title_full Novel mechanism for oscillations in catchbonded motor-filament complexes
title_fullStr Novel mechanism for oscillations in catchbonded motor-filament complexes
title_full_unstemmed Novel mechanism for oscillations in catchbonded motor-filament complexes
title_sort Novel mechanism for oscillations in catchbonded motor-filament complexes
dc.creator.none.fl_str_mv Guha, Sougata
Mitra, Mithun K.
Pagonabarraga Mora, Ignacio
Muhuri, Sudipto
author Guha, Sougata
author_facet Guha, Sougata
Mitra, Mithun K.
Pagonabarraga Mora, Ignacio
Muhuri, Sudipto
author_role author
author2 Mitra, Mithun K.
Pagonabarraga Mora, Ignacio
Muhuri, Sudipto
author2_role author
author
author
dc.subject.none.fl_str_mv Oscil·lacions
Citosquelet
Microtúbuls
Oscillations
Cytoskeleton
Microtubules
topic Oscil·lacions
Citosquelet
Microtúbuls
Oscillations
Cytoskeleton
Microtubules
description Generation of mechanical oscillations is ubiquitous to a wide variety of intracellular processes, ranging from activity of muscle fibers to oscillations of the mitotic spindle. The activity of motors plays a vital role in maintaining the integrity of the mitotic spindle structure and generating spontaneous oscillations. Although the structural features and properties of the individual motors are well characterized, their implications on the functional behavior of motor-filament complexes are more involved. We show that force-induced allosteric deformations in dynein, which result in catchbonding behavior, provide a generic mechanism to generate spontaneous oscillations in motor-cytoskeletal filament complexes. The resultant phase diagram of such motor-filament systems¿characterized by force-induced allosteric deformations¿exhibits bistability and sustained limit-cycle oscillations in biologically relevant regimes, such as for catchbonded dynein. The results reported here elucidate the central role of this mechanism in fashioning a distinctive stability behavior and oscillations in motor-filament complexes such as mitotic spindles.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/184772
url https://hdl.handle.net/2445/184772
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.bpj.2021.07.018
Biophysical Journal, 2021, vol. 120, num. 18, p. 4129
https://doi.org/10.1016/j.bpj.2021.07.018
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Biophysical Society, 2021
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Biophysical Society, 2021
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Biophysical Society
publisher.none.fl_str_mv Biophysical Society
dc.source.none.fl_str_mv Articles publicats en revistes (Física de la Matèria Condensada)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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