Virgin olive oil phenolic compounds modulate the HDL lipidome in hypercholesterolaemic subjects: a lipidomic analysis of the VOHF study

Scope: The lipidomic analysis of high-density lipoprotein (HDL) could be useful to identify new biomarkers of HDL function. Methods and results: A randomized, controlled, double-blind, crossover trial (33 hypercholesterolaemic subjects) is performed with a control virgin olive oil (VOO), VOO enriche...

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Autores: Fernández-Castillejo, Sara, Pedret, Anna, Catalán, Úrsula, Valls, Rosa M., Farràs Mañé, Marta, Rubió, Laura, Castañer, Olga, Macià, Alba, Fitó Colomer, Montserrat, Motilva, Maria-José, Covas Planells, Maria Isabel, Giera, Martin, Remaley, Alan T., Solà, Rosa
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/48754
Acesso em linha:http://hdl.handle.net/10230/48754
http://dx.doi.org/10.1002/mnfr.202001192
Access Level:acceso abierto
Palavra-chave:HDL functionality
Cholesterol efflux
Lipidomics
Polyphenols
Resistance to oxidation
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spelling Virgin olive oil phenolic compounds modulate the HDL lipidome in hypercholesterolaemic subjects: a lipidomic analysis of the VOHF studyFernández-Castillejo, SaraPedret, AnnaCatalán, ÚrsulaValls, Rosa M.Farràs Mañé, MartaRubió, LauraCastañer, OlgaMacià, AlbaFitó Colomer, MontserratMotilva, Maria-JoséCovas Planells, Maria IsabelGiera, MartinRemaley, Alan T.Solà, RosaHDL functionalityCholesterol effluxLipidomicsPolyphenolsResistance to oxidationScope: The lipidomic analysis of high-density lipoprotein (HDL) could be useful to identify new biomarkers of HDL function. Methods and results: A randomized, controlled, double-blind, crossover trial (33 hypercholesterolaemic subjects) is performed with a control virgin olive oil (VOO), VOO enriched with its own phenolic compounds (FVOO), or VOO enriched with additional phenolic compounds from thyme (FVOOT) for 3 weeks. HDL lipidomic analyses are performed using the Lipidyzer platform. VOO and FVOO intake increase monounsaturated-fatty acids (FAs) and decrease saturated and polyunsaturated FAs in triacylglyceride (TAG) species, among others species. In contrast, FVOOT intake does not induce these FAs changes. The decrease in TAG52:3(FA16:0) after VOO intake and the decrease in TAG52:5(FA18:2) after FVOO intake are inversely associated with changes in HDL resistance to oxidation. After FVOO intake, the decrease in TAG54:6(FA18:2) in HDL is inversely associated with changes in HDL cholesterol efflux capacity. Conclusion: VOO and FVOO consumption has an impact on the HDL lipidome, in particular TAG species. Although TAGs are minor components of HDL mass, the observed changes in TAG modulated HDL functionality towards a cardioprotective mode. The assessment of the HDL lipidome is a valuable approach to identify and characterize new biomarkers of HDL function.Wiley202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/48754http://dx.doi.org/10.1002/mnfr.202001192reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésMol Nutr Food Res. 2021;65(9):e2001192© 2021 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/487542026-05-29T05:05:01Z
dc.title.none.fl_str_mv Virgin olive oil phenolic compounds modulate the HDL lipidome in hypercholesterolaemic subjects: a lipidomic analysis of the VOHF study
title Virgin olive oil phenolic compounds modulate the HDL lipidome in hypercholesterolaemic subjects: a lipidomic analysis of the VOHF study
spellingShingle Virgin olive oil phenolic compounds modulate the HDL lipidome in hypercholesterolaemic subjects: a lipidomic analysis of the VOHF study
Fernández-Castillejo, Sara
HDL functionality
Cholesterol efflux
Lipidomics
Polyphenols
Resistance to oxidation
title_short Virgin olive oil phenolic compounds modulate the HDL lipidome in hypercholesterolaemic subjects: a lipidomic analysis of the VOHF study
title_full Virgin olive oil phenolic compounds modulate the HDL lipidome in hypercholesterolaemic subjects: a lipidomic analysis of the VOHF study
title_fullStr Virgin olive oil phenolic compounds modulate the HDL lipidome in hypercholesterolaemic subjects: a lipidomic analysis of the VOHF study
title_full_unstemmed Virgin olive oil phenolic compounds modulate the HDL lipidome in hypercholesterolaemic subjects: a lipidomic analysis of the VOHF study
title_sort Virgin olive oil phenolic compounds modulate the HDL lipidome in hypercholesterolaemic subjects: a lipidomic analysis of the VOHF study
dc.creator.none.fl_str_mv Fernández-Castillejo, Sara
Pedret, Anna
Catalán, Úrsula
Valls, Rosa M.
Farràs Mañé, Marta
Rubió, Laura
Castañer, Olga
Macià, Alba
Fitó Colomer, Montserrat
Motilva, Maria-José
Covas Planells, Maria Isabel
Giera, Martin
Remaley, Alan T.
Solà, Rosa
author Fernández-Castillejo, Sara
author_facet Fernández-Castillejo, Sara
Pedret, Anna
Catalán, Úrsula
Valls, Rosa M.
Farràs Mañé, Marta
Rubió, Laura
Castañer, Olga
Macià, Alba
Fitó Colomer, Montserrat
Motilva, Maria-José
Covas Planells, Maria Isabel
Giera, Martin
Remaley, Alan T.
Solà, Rosa
author_role author
author2 Pedret, Anna
Catalán, Úrsula
Valls, Rosa M.
Farràs Mañé, Marta
Rubió, Laura
Castañer, Olga
Macià, Alba
Fitó Colomer, Montserrat
Motilva, Maria-José
Covas Planells, Maria Isabel
Giera, Martin
Remaley, Alan T.
Solà, Rosa
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HDL functionality
Cholesterol efflux
Lipidomics
Polyphenols
Resistance to oxidation
topic HDL functionality
Cholesterol efflux
Lipidomics
Polyphenols
Resistance to oxidation
description Scope: The lipidomic analysis of high-density lipoprotein (HDL) could be useful to identify new biomarkers of HDL function. Methods and results: A randomized, controlled, double-blind, crossover trial (33 hypercholesterolaemic subjects) is performed with a control virgin olive oil (VOO), VOO enriched with its own phenolic compounds (FVOO), or VOO enriched with additional phenolic compounds from thyme (FVOOT) for 3 weeks. HDL lipidomic analyses are performed using the Lipidyzer platform. VOO and FVOO intake increase monounsaturated-fatty acids (FAs) and decrease saturated and polyunsaturated FAs in triacylglyceride (TAG) species, among others species. In contrast, FVOOT intake does not induce these FAs changes. The decrease in TAG52:3(FA16:0) after VOO intake and the decrease in TAG52:5(FA18:2) after FVOO intake are inversely associated with changes in HDL resistance to oxidation. After FVOO intake, the decrease in TAG54:6(FA18:2) in HDL is inversely associated with changes in HDL cholesterol efflux capacity. Conclusion: VOO and FVOO consumption has an impact on the HDL lipidome, in particular TAG species. Although TAGs are minor components of HDL mass, the observed changes in TAG modulated HDL functionality towards a cardioprotective mode. The assessment of the HDL lipidome is a valuable approach to identify and characterize new biomarkers of HDL function.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/48754
http://dx.doi.org/10.1002/mnfr.202001192
url http://hdl.handle.net/10230/48754
http://dx.doi.org/10.1002/mnfr.202001192
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Mol Nutr Food Res. 2021;65(9):e2001192
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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