METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. Here, we show that the transfer RNA N7-methylguanosine (m7G)...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/347759 |
| Acceso en línea: | http://hdl.handle.net/10261/347759 https://api.elsevier.com/content/abstract/scopus_id/85165971512 |
| Access Level: | acceso abierto |
| Palabra clave: | Epitranscriptome RNA modifications Prostate cancer 7-methylguanosine tRNA fragments Tumour microenvironment (TME) Interferon Immune checkpoint blockade |
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ES_5551ec84b9cd48fe7ef7df08969293bf |
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oai:digital.csic.es:10261/347759 |
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ES |
| network_name_str |
España |
| repository_id_str |
|
| dc.title.none.fl_str_mv |
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer |
| title |
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer |
| spellingShingle |
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer García-Vílchez, Raquel Epitranscriptome RNA modifications Prostate cancer 7-methylguanosine tRNA fragments Tumour microenvironment (TME) Interferon Immune checkpoint blockade |
| title_short |
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer |
| title_full |
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer |
| title_fullStr |
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer |
| title_full_unstemmed |
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer |
| title_sort |
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer |
| dc.creator.none.fl_str_mv |
García-Vílchez, Raquel Añazco-Guenkova, Ana M. Dietmann, Sabine López, Judith Morón-Calvente, Virginia D'Ambrosi, Silvia Nombela, Paz Zamacola, Kepa Mendizábal, Isabel García-Longarte, Saioa Zabala-Letona, Amaia Astobiza, Ianire Fernández, Sonia Paniagua, Alejandro Miguel-López, Borja Marchand, Virginie Alonso-López, Diego Merkel, Angelika García-Tuñón, Ignacio Ugalde-Olano, Aitziber Loizaga-Iriarte, Ana Lacasa-Viscasillas, Isabel Unda, Miguel Azkargorta, Mikel Elortza, Félix Bárcena, Laura Gonzalez-Lopez, Monika Aransay, Ana M. Di Domenico, Tomás Sánchez-Martín, Manuel A. De Las Rivas, Javier Guil, Sònia Motorin, Yuri Helm, Mark Pandolfi, Pier Paolo Carracedo, Arkaitz Blanco, Sandra |
| author |
García-Vílchez, Raquel |
| author_facet |
García-Vílchez, Raquel Añazco-Guenkova, Ana M. Dietmann, Sabine López, Judith Morón-Calvente, Virginia D'Ambrosi, Silvia Nombela, Paz Zamacola, Kepa Mendizábal, Isabel García-Longarte, Saioa Zabala-Letona, Amaia Astobiza, Ianire Fernández, Sonia Paniagua, Alejandro Miguel-López, Borja Marchand, Virginie Alonso-López, Diego Merkel, Angelika García-Tuñón, Ignacio Ugalde-Olano, Aitziber Loizaga-Iriarte, Ana Lacasa-Viscasillas, Isabel Unda, Miguel Azkargorta, Mikel Elortza, Félix Bárcena, Laura Gonzalez-Lopez, Monika Aransay, Ana M. Di Domenico, Tomás Sánchez-Martín, Manuel A. De Las Rivas, Javier Guil, Sònia Motorin, Yuri Helm, Mark Pandolfi, Pier Paolo Carracedo, Arkaitz Blanco, Sandra |
| author_role |
author |
| author2 |
Añazco-Guenkova, Ana M. Dietmann, Sabine López, Judith Morón-Calvente, Virginia D'Ambrosi, Silvia Nombela, Paz Zamacola, Kepa Mendizábal, Isabel García-Longarte, Saioa Zabala-Letona, Amaia Astobiza, Ianire Fernández, Sonia Paniagua, Alejandro Miguel-López, Borja Marchand, Virginie Alonso-López, Diego Merkel, Angelika García-Tuñón, Ignacio Ugalde-Olano, Aitziber Loizaga-Iriarte, Ana Lacasa-Viscasillas, Isabel Unda, Miguel Azkargorta, Mikel Elortza, Félix Bárcena, Laura Gonzalez-Lopez, Monika Aransay, Ana M. Di Domenico, Tomás Sánchez-Martín, Manuel A. De Las Rivas, Javier Guil, Sònia Motorin, Yuri Helm, Mark Pandolfi, Pier Paolo Carracedo, Arkaitz Blanco, Sandra |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Ministerio de Economía y Competitividad (España) Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) Instituto de Salud Carlos III Junta de Castilla y León Universidad de Salamanca Banco Santander Asociación Española Contra el Cáncer Fundación CRIS contra el Cáncer Fundación la Caixa European Research Council European Commission Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Epitranscriptome RNA modifications Prostate cancer 7-methylguanosine tRNA fragments Tumour microenvironment (TME) Interferon Immune checkpoint blockade |
| topic |
Epitranscriptome RNA modifications Prostate cancer 7-methylguanosine tRNA fragments Tumour microenvironment (TME) Interferon Immune checkpoint blockade |
| description |
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. Here, we show that the transfer RNA N7-methylguanosine (m7G) transferase METTL1 is highly expressed in primary and advanced prostate tumours. Mechanistically, we find that METTL1 depletion causes the loss of m7G tRNA methylation and promotes the biogenesis of a novel class of small non-coding RNAs derived from 5'tRNA fragments. 5'tRNA-derived small RNAs steer translation control to favour the synthesis of key regulators of tumour growth suppression, interferon pathway, and immune effectors. Knockdown of Mettl1 in prostate cancer preclinical models increases intratumoural infiltration of pro-inflammatory immune cells and enhances responses to immunotherapy. Collectively, our findings reveal a therapeutically actionable role of METTL1-directed m7G tRNA methylation in cancer cell translation control and tumour biology. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/347759 https://api.elsevier.com/content/abstract/scopus_id/85165971512 |
| url |
http://hdl.handle.net/10261/347759 https://api.elsevier.com/content/abstract/scopus_id/85165971512 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
#PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI//SAF2016-78667-R info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111692RB-I00 info:eu-repo/grantAgreement/MINECO//RYC-2014-16550 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108787RB-I00 info:eu-repo/grantAgreement/AEI//RED2018-102769-T Molecular cancer García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 1 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540593.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 3 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540602.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 2 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540596.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 4 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540605.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 5 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540608.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 6 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540611.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 7 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer]; Figshare; https://doi.org/10.6084/m9.figshare.24540614.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 8 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540617.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 9 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540620.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 10 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540629.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023 Additional file 11 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540632.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 12 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540635.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 13 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer]; Figshare; https://doi.org/10.6084/m9.figshare.24540638.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 14 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540641.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 15 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540644.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 16 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540647.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 17 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540650.v1 García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 18 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540653.v1 https://doi.org/10.1186/s12943-023-01809-8 Sí |
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METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancerGarcía-Vílchez, RaquelAñazco-Guenkova, Ana M.Dietmann, SabineLópez, JudithMorón-Calvente, VirginiaD'Ambrosi, SilviaNombela, PazZamacola, KepaMendizábal, IsabelGarcía-Longarte, SaioaZabala-Letona, AmaiaAstobiza, IanireFernández, SoniaPaniagua, AlejandroMiguel-López, BorjaMarchand, VirginieAlonso-López, DiegoMerkel, AngelikaGarcía-Tuñón, IgnacioUgalde-Olano, AitziberLoizaga-Iriarte, AnaLacasa-Viscasillas, IsabelUnda, MiguelAzkargorta, MikelElortza, FélixBárcena, LauraGonzalez-Lopez, MonikaAransay, Ana M.Di Domenico, TomásSánchez-Martín, Manuel A.De Las Rivas, JavierGuil, SòniaMotorin, YuriHelm, MarkPandolfi, Pier PaoloCarracedo, ArkaitzBlanco, SandraEpitranscriptomeRNA modificationsProstate cancer7-methylguanosinetRNA fragmentsTumour microenvironment (TME)InterferonImmune checkpoint blockadeNewly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. Here, we show that the transfer RNA N7-methylguanosine (m7G) transferase METTL1 is highly expressed in primary and advanced prostate tumours. Mechanistically, we find that METTL1 depletion causes the loss of m7G tRNA methylation and promotes the biogenesis of a novel class of small non-coding RNAs derived from 5'tRNA fragments. 5'tRNA-derived small RNAs steer translation control to favour the synthesis of key regulators of tumour growth suppression, interferon pathway, and immune effectors. Knockdown of Mettl1 in prostate cancer preclinical models increases intratumoural infiltration of pro-inflammatory immune cells and enhances responses to immunotherapy. Collectively, our findings reveal a therapeutically actionable role of METTL1-directed m7G tRNA methylation in cancer cell translation control and tumour biology.This work was funded by the Spanish Ministry of Science and Innovation MICINN/AEI/1013039/501100011033 and by “ERDF A way of making Europe”, by the “European Union” (SAF2016-78667-R and PID2019-111692RB-I00), MINECO (RYC-2014-16550), AECC (LABAE19040BLAN), Proteored-ISCIII, and Consejería de Educación de la Junta de Castilla y León (CSI264P20). R.G-V. was supported by MICINN/AEI/1013039/501100011033 and by “ESF Investing in your future” (BES-2017-080530). A.M.A-G. was supported by the USAL-Santander PhD fellowship. J.L-L. was supported by the AECC (PRDSA19002LÓPE) and MIU(FPU19/01190). B.M.L. was supported by Junta de Castilla y León ‐ Fondo Social Europeo (ESF). I.M. was supported by the Cris contra el cáncer grant PR_TPD_2020-19. The work of A. Carracedo is supported by the MICINN (PID2019-108787RB-I00 (FEDER/EU); Excellence Networks RED2018-102769-T), the AECC (GCTRA18006CARR), La Caixa Foundation (ID 100010434), under the agreement LCF/PR/HR17/ and the European Research Council (Consolidator Grant 819242). CIBERONC was co-funded by FEDER funds and ISCIII. The Instituto de Biología Molecular y Celular del Cancer is supported by the Programa de Apoyo a Planes Estratégicos de Investigación de Estructuras de Investigación de Excelencia co-financed by the Castilla–León autonomous government and the European Regional Development Fund (CLC–2017–01).Peer reviewedBioMed CentralMinisterio de Economía y Competitividad (España)Ministerio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Instituto de Salud Carlos IIIJunta de Castilla y LeónUniversidad de SalamancaBanco SantanderAsociación Española Contra el CáncerFundación CRIS contra el CáncerFundación la CaixaEuropean Research CouncilEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/347759https://api.elsevier.com/content/abstract/scopus_id/85165971512reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//SAF2016-78667-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111692RB-I00info:eu-repo/grantAgreement/MINECO//RYC-2014-16550info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108787RB-I00info:eu-repo/grantAgreement/AEI//RED2018-102769-TMolecular cancerGarcía-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 1 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540593.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 3 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540602.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 2 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540596.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 4 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540605.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 5 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540608.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 6 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540611.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 7 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer]; Figshare; https://doi.org/10.6084/m9.figshare.24540614.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 8 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540617.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 9 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540620.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 10 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540629.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023 Additional file 11 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540632.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 12 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540635.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 13 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer]; Figshare; https://doi.org/10.6084/m9.figshare.24540638.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 14 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540641.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 15 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540644.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 16 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540647.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 17 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540650.v1García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D'Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizábal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Gonzalez-Lopez, Monika; Aransay, Ana M.; Di Domenico, Tomás; Sánchez-Martín, Manuel A.; De Las Rivas, Javier; Guil, Sònia; Motorin, Yuri; Helm, Mark; Pandolfi, Pier Paolo; Carracedo, Arkaitz; Blanco, Sandra; 2023; Additional file 18 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.24540653.v1https://doi.org/10.1186/s12943-023-01809-8Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3477592026-05-22T06:33:51Z |
| score |
15,812429 |