Genetic Predisposition to Alzheimer’s Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region

ALFA Study.-- This article belongs to the Special Issue Genetic Research of Neurodegenerative and Psychiatric Disorders.

Detalles Bibliográficos
Autores: Ciampa, Iacopo, Operto, Grégory, Falcon, Carles, Minguillón, Carolina, Castro de Moura, Manuel, Piñeyro, David, Esteller, Manel, Molinuevo, José Luis, Guigó, Roderic, Navarro, Arcadi, Gispert, Juan Domingo, Vilor-Tejedor, Natalia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/247824
Acceso en línea:http://hdl.handle.net/10261/247824
Access Level:acceso abierto
Palabra clave:APOE-ε4
BIN1-rs744373
Enlargement of perivascular spaces
Neurogenetics
Virchow robin spaces
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spelling Genetic Predisposition to Alzheimer’s Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale RegionCiampa, IacopoOperto, GrégoryFalcon, CarlesMinguillón, CarolinaCastro de Moura, ManuelPiñeyro, DavidEsteller, ManelMolinuevo, José LuisGuigó, RodericNavarro, ArcadiGispert, Juan DomingoVilor-Tejedor, NataliaAPOE-ε4BIN1-rs744373Enlargement of perivascular spacesNeurogeneticsVirchow robin spacesALFA Study.-- This article belongs to the Special Issue Genetic Research of Neurodegenerative and Psychiatric Disorders.This study investigated whether genetic factors involved in Alzheimer’s disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and genetic information were acquired from the ALFA study. ePVS in the basal ganglia (BG) and the centrum semiovale (CS) were assessed based on a validated visual rating scale. We used univariate and multivariate logistic regression models to investigate associations between ePVS in BG and CS with BIN1-rs744373, as well as APOE genotypes. We found a significant association of the BIN1-rs744373 polymorphism in the CS subscale (p value = 0.019; OR = 2.564), suggesting that G allele carriers have an increased risk of ePVS in comparison with A allele carriers. In stratified analysis by APOE-ε4 status (carriers vs. non-carriers), these results remained significant only for ε4 carriers (p value = 0.011; OR = 1.429). To our knowledge, the present study is the first suggesting that genetic predisposition for AD is associated with ePVS in CS. These findings provide evidence that underlying biological processes affecting AD may influence CS-ePVS.The project leading to these results has received funding from “la Caixa” Foundation (ID 100010434), under agreement LCF/PR/GN17/50300004, the Alzheimer’s Association and an international anonymous charity foundation through the TriBEKa Imaging Platform project (TriBEKa-17-519007) and the Health Department of the Catalan Government (Health Research and Innovation Strategic Plan (PERIS) 2016-2020 grant# SLT002/16/00201). Additional support has been received from the Universities and Research Secretariat, Ministry of Business and Knowledge of the Catalan Government under the grant no. 2017-SGR-892. All CRG authors acknowledge the support of the Spanish Ministry of Science, Innovation and Universities to the EMBL partnership, the Centro de Excelencia Severo Ochoa and the CERCA Programme / Generalitat de Catalunya. JDG is supported by the Spanish Ministry of Science and Innovation (RYC-2013-13054). NV-T is funded by a postdoctoral grant, Juan de la Cierva Programme (FJC2018-038085-I), Ministry of Science and Innovation—Spanish State Research Agency.Peer reviewedMultidisciplinary Digital Publishing InstituteFundación la CaixaAlzheimer's AssociationGeneralitat de CatalunyaMinisterio de Ciencia, Innovación y Universidades (España)Ministerio de Economía y Competitividad (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/247824reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC-2013-13054info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/FJC2018-038085-Ihttps://doi.org/10.3390/genes12060825Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2478242026-05-22T06:33:51Z
dc.title.none.fl_str_mv Genetic Predisposition to Alzheimer’s Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region
title Genetic Predisposition to Alzheimer’s Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region
spellingShingle Genetic Predisposition to Alzheimer’s Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region
Ciampa, Iacopo
APOE-ε4
BIN1-rs744373
Enlargement of perivascular spaces
Neurogenetics
Virchow robin spaces
title_short Genetic Predisposition to Alzheimer’s Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region
title_full Genetic Predisposition to Alzheimer’s Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region
title_fullStr Genetic Predisposition to Alzheimer’s Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region
title_full_unstemmed Genetic Predisposition to Alzheimer’s Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region
title_sort Genetic Predisposition to Alzheimer’s Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region
dc.creator.none.fl_str_mv Ciampa, Iacopo
Operto, Grégory
Falcon, Carles
Minguillón, Carolina
Castro de Moura, Manuel
Piñeyro, David
Esteller, Manel
Molinuevo, José Luis
Guigó, Roderic
Navarro, Arcadi
Gispert, Juan Domingo
Vilor-Tejedor, Natalia
author Ciampa, Iacopo
author_facet Ciampa, Iacopo
Operto, Grégory
Falcon, Carles
Minguillón, Carolina
Castro de Moura, Manuel
Piñeyro, David
Esteller, Manel
Molinuevo, José Luis
Guigó, Roderic
Navarro, Arcadi
Gispert, Juan Domingo
Vilor-Tejedor, Natalia
author_role author
author2 Operto, Grégory
Falcon, Carles
Minguillón, Carolina
Castro de Moura, Manuel
Piñeyro, David
Esteller, Manel
Molinuevo, José Luis
Guigó, Roderic
Navarro, Arcadi
Gispert, Juan Domingo
Vilor-Tejedor, Natalia
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fundación la Caixa
Alzheimer's Association
Generalitat de Catalunya
Ministerio de Ciencia, Innovación y Universidades (España)
Ministerio de Economía y Competitividad (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv APOE-ε4
BIN1-rs744373
Enlargement of perivascular spaces
Neurogenetics
Virchow robin spaces
topic APOE-ε4
BIN1-rs744373
Enlargement of perivascular spaces
Neurogenetics
Virchow robin spaces
description ALFA Study.-- This article belongs to the Special Issue Genetic Research of Neurodegenerative and Psychiatric Disorders.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/247824
url http://hdl.handle.net/10261/247824
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC-2013-13054
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/FJC2018-038085-I
https://doi.org/10.3390/genes12060825
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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