CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease

In Huntington's disease (HD), striatal medium spiny neurons (MSNs) are particularly sensitive to the presence of a CAG repeat in the huntingtin (HTT) gene. However, there are many evidences that cells from the peripheral immune system and central nervous system (CNS) immune cells, namely microg...

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Autores: Comella Bolla, Andrea, Valente, Tony, Miguez, Andrés, Brito, Verónica, Ginés Padrós, Silvia, Solà i Subirana, Carme, Straccia, Marco, Canals i Coll, Josep M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/180660
Acceso en línea:https://hdl.handle.net/2445/180660
Access Level:acceso abierto
Palabra clave:Corea de Huntington
Huntington's chorea
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spelling CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's diseaseComella Bolla, AndreaValente, TonyMiguez, AndrésBrito, VerónicaGinés Padrós, SilviaSolà i Subirana, CarmeStraccia, MarcoCanals i Coll, Josep M.Corea de HuntingtonHuntington's choreaIn Huntington's disease (HD), striatal medium spiny neurons (MSNs) are particularly sensitive to the presence of a CAG repeat in the huntingtin (HTT) gene. However, there are many evidences that cells from the peripheral immune system and central nervous system (CNS) immune cells, namely microglia, play an important role in the etiology and the progression of HD. However, it remains unclear whether MSNs neurodegeneration is mediated by a non-cell autonomous mechanism. The homeostasis in the healthy CNS is maintained by several mechanisms of interaction between all brain cells. Neurons can control microglia activation through several inhibitory mechanisms, such as the CD200-CD200R1 interaction. Due to the complete lack of knowledge about the CD200-CD200R1 system in HD, we determined the temporal patterns of CD200 and CD200R1 expression in the neocortex, hippocampus and striatum in the HD mouse models R6/1 and HdhQ111/7 from pre-symptomatic to manifest stages. In order to explore any alteration in the peripheral immune system, we also studied the levels of expression of CD200 and CD200R1 in whole blood. Although CD200R1 expression was not altered, we observed and increase in CD200 gene expression and protein levels in the brain parenchyma of all the regions we examined, along with HD pathogenesis in R6/1 mice. Interestingly, the expression of CD200 mRNA was also up-regulated in blood following a similar temporal pattern. These results suggest that canonical neuronal-microglial communication through CD200-CD200R1 interaction is not compromised, and CD200 up-regulation in R6/1 brain parenchyma could represent a neurotrophic signal to sustain or extend neuronal function in the latest stages of HD as pro-survival mechanism.Public Library of Science (PLoS)2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/180660Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0224901PLoS One, 2019, vol. 14, num. 12https://doi.org/10.1371/journal.pone.0224901cc-by (c) Comella Bolla, Andrea et al., 2019https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1806602026-05-27T06:46:51Z
dc.title.none.fl_str_mv CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease
title CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease
spellingShingle CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease
Comella Bolla, Andrea
Corea de Huntington
Huntington's chorea
title_short CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease
title_full CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease
title_fullStr CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease
title_full_unstemmed CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease
title_sort CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease
dc.creator.none.fl_str_mv Comella Bolla, Andrea
Valente, Tony
Miguez, Andrés
Brito, Verónica
Ginés Padrós, Silvia
Solà i Subirana, Carme
Straccia, Marco
Canals i Coll, Josep M.
author Comella Bolla, Andrea
author_facet Comella Bolla, Andrea
Valente, Tony
Miguez, Andrés
Brito, Verónica
Ginés Padrós, Silvia
Solà i Subirana, Carme
Straccia, Marco
Canals i Coll, Josep M.
author_role author
author2 Valente, Tony
Miguez, Andrés
Brito, Verónica
Ginés Padrós, Silvia
Solà i Subirana, Carme
Straccia, Marco
Canals i Coll, Josep M.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Corea de Huntington
Huntington's chorea
topic Corea de Huntington
Huntington's chorea
description In Huntington's disease (HD), striatal medium spiny neurons (MSNs) are particularly sensitive to the presence of a CAG repeat in the huntingtin (HTT) gene. However, there are many evidences that cells from the peripheral immune system and central nervous system (CNS) immune cells, namely microglia, play an important role in the etiology and the progression of HD. However, it remains unclear whether MSNs neurodegeneration is mediated by a non-cell autonomous mechanism. The homeostasis in the healthy CNS is maintained by several mechanisms of interaction between all brain cells. Neurons can control microglia activation through several inhibitory mechanisms, such as the CD200-CD200R1 interaction. Due to the complete lack of knowledge about the CD200-CD200R1 system in HD, we determined the temporal patterns of CD200 and CD200R1 expression in the neocortex, hippocampus and striatum in the HD mouse models R6/1 and HdhQ111/7 from pre-symptomatic to manifest stages. In order to explore any alteration in the peripheral immune system, we also studied the levels of expression of CD200 and CD200R1 in whole blood. Although CD200R1 expression was not altered, we observed and increase in CD200 gene expression and protein levels in the brain parenchyma of all the regions we examined, along with HD pathogenesis in R6/1 mice. Interestingly, the expression of CD200 mRNA was also up-regulated in blood following a similar temporal pattern. These results suggest that canonical neuronal-microglial communication through CD200-CD200R1 interaction is not compromised, and CD200 up-regulation in R6/1 brain parenchyma could represent a neurotrophic signal to sustain or extend neuronal function in the latest stages of HD as pro-survival mechanism.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/180660
url https://hdl.handle.net/2445/180660
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0224901
PLoS One, 2019, vol. 14, num. 12
https://doi.org/10.1371/journal.pone.0224901
dc.rights.none.fl_str_mv cc-by (c) Comella Bolla, Andrea et al., 2019
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Comella Bolla, Andrea et al., 2019
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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