Exosomes genetic cargo in lung cancer: a truly Pandora s box

[EN] Lung cancer is a highly lethal disease. Targeted therapies have been developed in last years, however survival rates are not improving due to the delay in the diagnosis, making biomarkers one of the most interesting fields of study in cancer. Liquid biopsy has raised as an alternative to tissue...

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Autores: Reclusa P, Araujo, A, Giallombardo, M, Valentino, A, Sober, L, Gil Bazo, I, Pauwels, P, Rolfo, C, Sirera Pérez, Rafael|||0000-0001-9162-8490
Formato: artículo
Fecha de publicación:2016
País:España
Recursos:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/92942
Acesso em linha:https://riunet.upv.es/handle/10251/92942
Access Level:acceso abierto
Palavra-chave:Non-small cell lung cancer (NSCLC)
Exosomes
NcRNAs
Liquid biopsy
MICROBIOLOGIA
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spelling Exosomes genetic cargo in lung cancer: a truly Pandora s boxReclusa PAraujo, AGiallombardo, MValentino, ASober, LGil Bazo, IPauwels, PRolfo, CSirera Pérez, Rafael|||0000-0001-9162-8490Non-small cell lung cancer (NSCLC)ExosomesNcRNAsLiquid biopsyMICROBIOLOGIA[EN] Lung cancer is a highly lethal disease. Targeted therapies have been developed in last years, however survival rates are not improving due to the delay in the diagnosis, making biomarkers one of the most interesting fields of study in cancer. Liquid biopsy has raised as an alternative to tissue biopsy due to improvements in analytical techniques for circulating tumor cells (CTCs), cell free DNA and exosomes. Among all, exosomes have raised as one of the most promising tools to understand the tumor due to their stability in the blood and their similarity to the cells of origin. In the last years, different alterations have been described inside the exosomes derived from non-small cell lung cancer (NSCLC) cells mirroring the processes inside these tumoral cells, such as EGFR mutation, translocations or microRNA (miRNA) deregulation. All these studies have opened the window to a new world of possibilities in the study of tumor biomarkers.AME Publishing CompanyDepartamento de BiotecnologíaCentro Avanzado de Microbiología AplicadaEscuela Técnica Superior de Ingeniería Agronómica y del Medio NaturalRepositorio Institucional de la Universitat Politècnica de València Riunet20162016-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/92942reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/929422026-06-13T07:49:27Z
dc.title.none.fl_str_mv Exosomes genetic cargo in lung cancer: a truly Pandora s box
title Exosomes genetic cargo in lung cancer: a truly Pandora s box
spellingShingle Exosomes genetic cargo in lung cancer: a truly Pandora s box
Reclusa P
Non-small cell lung cancer (NSCLC)
Exosomes
NcRNAs
Liquid biopsy
MICROBIOLOGIA
title_short Exosomes genetic cargo in lung cancer: a truly Pandora s box
title_full Exosomes genetic cargo in lung cancer: a truly Pandora s box
title_fullStr Exosomes genetic cargo in lung cancer: a truly Pandora s box
title_full_unstemmed Exosomes genetic cargo in lung cancer: a truly Pandora s box
title_sort Exosomes genetic cargo in lung cancer: a truly Pandora s box
dc.creator.none.fl_str_mv Reclusa P
Araujo, A
Giallombardo, M
Valentino, A
Sober, L
Gil Bazo, I
Pauwels, P
Rolfo, C
Sirera Pérez, Rafael|||0000-0001-9162-8490
author Reclusa P
author_facet Reclusa P
Araujo, A
Giallombardo, M
Valentino, A
Sober, L
Gil Bazo, I
Pauwels, P
Rolfo, C
Sirera Pérez, Rafael|||0000-0001-9162-8490
author_role author
author2 Araujo, A
Giallombardo, M
Valentino, A
Sober, L
Gil Bazo, I
Pauwels, P
Rolfo, C
Sirera Pérez, Rafael|||0000-0001-9162-8490
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Biotecnología
Centro Avanzado de Microbiología Aplicada
Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Non-small cell lung cancer (NSCLC)
Exosomes
NcRNAs
Liquid biopsy
MICROBIOLOGIA
topic Non-small cell lung cancer (NSCLC)
Exosomes
NcRNAs
Liquid biopsy
MICROBIOLOGIA
description [EN] Lung cancer is a highly lethal disease. Targeted therapies have been developed in last years, however survival rates are not improving due to the delay in the diagnosis, making biomarkers one of the most interesting fields of study in cancer. Liquid biopsy has raised as an alternative to tissue biopsy due to improvements in analytical techniques for circulating tumor cells (CTCs), cell free DNA and exosomes. Among all, exosomes have raised as one of the most promising tools to understand the tumor due to their stability in the blood and their similarity to the cells of origin. In the last years, different alterations have been described inside the exosomes derived from non-small cell lung cancer (NSCLC) cells mirroring the processes inside these tumoral cells, such as EGFR mutation, translocations or microRNA (miRNA) deregulation. All these studies have opened the window to a new world of possibilities in the study of tumor biomarkers.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/92942
url https://riunet.upv.es/handle/10251/92942
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv AME Publishing Company
publisher.none.fl_str_mv AME Publishing Company
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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