Tick and host derived compounds detected in the cement complex substance

Villar, Margarita; Pacheco, Iván; Merino, Octavio; Contreras, Marinela; Mateos-Hernández, Lourdes; Prado, Eduardo; Barros-Picanço, Dina Karen; Lima-Barbero, José Francisco; Artigas-Jerónimo, Sara; Alberdi, Pilar; Fernández de Mera, Isabel G.; Estrada-Peña, Agustín; Cabezas-Cruz, Alejandro; Fuente, José de la

Tick and host derived compounds detected in the cement complex substance

This article belongs to the Special Issue Ectoparasite Biogenic Components in the Modulation of Vector-host-pathogen Interactions.

Detalles Bibliográficos
Autores:	Villar, Margarita, Pacheco, Iván, Merino, Octavio, Contreras, Marinela, Mateos-Hernández, Lourdes, Prado, Eduardo, Barros-Picanço, Dina Karen, Lima-Barbero, José Francisco, Artigas-Jerónimo, Sara, Alberdi, Pilar, Fernández de Mera, Isabel G., Estrada-Peña, Agustín, Cabezas-Cruz, Alejandro, Fuente, José de la
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2020
País:	España
Institución:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:	oai:digital.csic.es:10261/221665
Acceso en línea:	http://hdl.handle.net/10261/221665
Access Level:	acceso abierto
Palabra clave:	Tick Cement Dispersive energy X-ray spectroscopy Sialome

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spelling	Tick and host derived compounds detected in the cement complex substanceVillar, MargaritaPacheco, IvánMerino, OctavioContreras, MarinelaMateos-Hernández, LourdesPrado, EduardoBarros-Picanço, Dina KarenLima-Barbero, José FranciscoArtigas-Jerónimo, SaraAlberdi, PilarFernández de Mera, Isabel G.Estrada-Peña, AgustínCabezas-Cruz, AlejandroFuente, José de laTickCementDispersive energy X-ray spectroscopySialomeThis article belongs to the Special Issue Ectoparasite Biogenic Components in the Modulation of Vector-host-pathogen Interactions.Ticks are obligate hematophagous arthropods and vectors of pathogens affecting human and animal health worldwide. Cement is a complex protein polymerization substance secreted by ticks with antimicrobial properties and a possible role in host attachment, sealing the feeding lesion, facilitating feeding and pathogen transmission, and protection from host immune and inflammatory responses. The biochemical properties of tick cement during feeding have not been fully characterized. In this study, we characterized the proteome of Rhipicephalus microplus salivary glands (sialome) and cement (cementome) together with their physicochemical properties at different adult female parasitic stages. The results showed the combination of tick and host derived proteins and other biomolecules such as α-Gal in cement composition, which varied during the feeding process. We propose that these compounds may synergize in cement formation, solidification and maintenance to facilitate attachment, feeding, interference with host immune response and detachment. These results advanced our knowledge of the complex tick cement composition and suggested that tick and host derived compounds modulate cement properties throughout tick feeding.This research was funded by the Consejería de Educación, Cultura y Deportes, JCCM, Spain, project CCM17-PIC-036 (SBPLY/17/180501/000185). M.V. was supported by the University of Castilla La Mancha, UCLM, Spain, and the Fondo Europeo de Desarrollo Regional, FEDER, EU. I.G.F.M. was supported by the University of Castilla La Mancha, UCLM, Spain.Peer reviewedMultidisciplinary Digital Publishing InstituteJunta de Comunidades de Castilla-La ManchaUniversidad de Castilla La ManchaEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/221665reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/biom10040555Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2216652026-05-22T06:33:51Z
dc.title.none.fl_str_mv	Tick and host derived compounds detected in the cement complex substance
title	Tick and host derived compounds detected in the cement complex substance
spellingShingle	Tick and host derived compounds detected in the cement complex substance Villar, Margarita Tick Cement Dispersive energy X-ray spectroscopy Sialome
title_short	Tick and host derived compounds detected in the cement complex substance
title_full	Tick and host derived compounds detected in the cement complex substance
title_fullStr	Tick and host derived compounds detected in the cement complex substance
title_full_unstemmed	Tick and host derived compounds detected in the cement complex substance
title_sort	Tick and host derived compounds detected in the cement complex substance
dc.creator.none.fl_str_mv	Villar, Margarita Pacheco, Iván Merino, Octavio Contreras, Marinela Mateos-Hernández, Lourdes Prado, Eduardo Barros-Picanço, Dina Karen Lima-Barbero, José Francisco Artigas-Jerónimo, Sara Alberdi, Pilar Fernández de Mera, Isabel G. Estrada-Peña, Agustín Cabezas-Cruz, Alejandro Fuente, José de la
author	Villar, Margarita
author_facet	Villar, Margarita Pacheco, Iván Merino, Octavio Contreras, Marinela Mateos-Hernández, Lourdes Prado, Eduardo Barros-Picanço, Dina Karen Lima-Barbero, José Francisco Artigas-Jerónimo, Sara Alberdi, Pilar Fernández de Mera, Isabel G. Estrada-Peña, Agustín Cabezas-Cruz, Alejandro Fuente, José de la
author_role	author
author2	Pacheco, Iván Merino, Octavio Contreras, Marinela Mateos-Hernández, Lourdes Prado, Eduardo Barros-Picanço, Dina Karen Lima-Barbero, José Francisco Artigas-Jerónimo, Sara Alberdi, Pilar Fernández de Mera, Isabel G. Estrada-Peña, Agustín Cabezas-Cruz, Alejandro Fuente, José de la
author2_role	author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Junta de Comunidades de Castilla-La Mancha Universidad de Castilla La Mancha European Commission Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv	Tick Cement Dispersive energy X-ray spectroscopy Sialome
topic	Tick Cement Dispersive energy X-ray spectroscopy Sialome
description	This article belongs to the Special Issue Ectoparasite Biogenic Components in the Modulation of Vector-host-pathogen Interactions.
publishDate	2020
dc.date.none.fl_str_mv	2020 2020 2020
dc.type.none.fl_str_mv	info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10261/221665
url	http://hdl.handle.net/10261/221665
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	https://doi.org/10.3390/biom10040555 Sí
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv	Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv	reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str	Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str	DIGITAL.CSIC. Repositorio Institucional del CSIC
collection	DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.81155

Tick and host derived compounds detected in the cement complex substance

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