Cost-effective laser diode scanning 3D photoacoustic microscopy of melanocytic dermal tumors in situ

[EN] Management of melanoma skin cancer involves a wide excision followed by histopathological analysis to confirm the diagnosis, which is only guided by superficial dermoscopy. Dermatological oncology can thus benefit from high-resolution, 3D images provided by photoacoustic microscopy; however, it...

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Detalles Bibliográficos
Autores: Navarro-Calvo, Javier Ángel|||0000-0002-2589-873X, Cebrecos, Alejandro|||0000-0001-8790-8668, Arándiga-Martínez, Adrián Luis, Lorenzo-Rebenaque, Laura|||0000-0002-4759-258X, Marco-Jiménez, Francisco|||0000-0002-5226-4118, Benlloch Baviera, Jose María|||0000-0001-6073-1436, Camarena Femenia, Francisco|||0000-0002-6713-1414, García-Garrigos, Juan José
Tipo de recurso: artículo
Fecha de publicación:2026
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:dnet:riunet______::030b18a27893b07a01b4a5e941b348bd
Acceso en línea:https://riunet.upv.es/handle/10251/234414
Access Level:acceso abierto
Palabra clave:Laser diode scanning
Cost-effective 3D photoacoustic microscopy
Melanoma imaging
Point of care
Descripción
Sumario:[EN] Management of melanoma skin cancer involves a wide excision followed by histopathological analysis to confirm the diagnosis, which is only guided by superficial dermoscopy. Dermatological oncology can thus benefit from high-resolution, 3D images provided by photoacoustic microscopy; however, its clinical translation is hindered by its elevated cost. Opening a pathway to point-of-care 3D melanoma assessment, we present the first demonstration of a cost-effective photoacoustic microscope (CePAM) utilizing fast laser diode scanning with a focused transducer in reflection mode. A novel application of a direct model inversion (DiMI) algorithm allowed a 55-fold enlargement of the image field of view beyond the transducer acoustic focus, reaching a 1-square millimeter laser-scanned area with uniform sensitivity (>20 dB). Furthermore, DiMI improved the intrinsic axial resolution of the system via multiple selective-plane scanning. The feasibility of CePAM is demonstrated by quantitative tests on phantoms and in vivo imaging of murine melanocytic dermal tumors, yielding accurate 3D images and virtual cross-sections consistent with histology.

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