Nicotinamide protects against diet-induced body weight gain, increases energy expenditure, and induces white adipose tissue beiging
Scope: Interventions that boost NAD+ availability are of potential therapeutic interest for obesity treatment. The potential of nicotinamide (NAM), the amide form of vitamin B3 and a physiological precursor of nicotinamide adenine dinucleotide (NAD)+, in preventing weight gain has not previously bee...
| Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | article |
| Publication Date: | 2021 |
| Country: | España |
| Institution: | Universitat Autònoma de Barcelona |
| Repository: | Dipòsit Digital de Documents de la UAB |
| Language: | English |
| OAI Identifier: | oai:ddd.uab.cat:271568 |
| Online Access: | https://ddd.uab.cat/record/271568 https://dx.doi.org/urn:doi:10.1002/mnfr.202100111 |
| Access Level: | Open access |
| Keyword: | Adiposity Beiging Fatty liver Inflammation SDG 3 - Good Health and Well-being |
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Nicotinamide protects against diet-induced body weight gain, increases energy expenditure, and induces white adipose tissue beigingMéndez Lara, Karen Alejandra|||0000-0002-8372-2310Rodríguez-Millán, ElisabethSebastián, David|||0000-0002-7260-3869Blanco-Soto, RosiCamacho, Mercedes|||0000-0001-5970-3294Nan, Madalina Nicoleta|||0009-0001-2794-447XDiarte-Añazco, E. M. G.|||0000-0003-3876-9918Mato, Eugènia|||0000-0001-8121-9335Lope-Piedrafita, Silvia|||0000-0002-8127-6425Roglans, NúriaLaguna, Joan Carles|||0000-0002-2357-1186Alonso Pedrol, Núria|||0000-0001-9687-8050Mauricio, Didac|||0000-0002-2868-0250Zorzano Olarte, Antonio|||0000-0002-1638-0306Villarroya, Francesc|||0000-0003-1266-9142Villena, Josep A.|||0000-0002-2200-2985Blanco Vaca, Francisco|||0000-0001-7380-5385Julve i Gil, Josep|||0000-0002-6531-2246AdiposityBeigingFatty liverInflammationSDG 3 - Good Health and Well-beingScope: Interventions that boost NAD+ availability are of potential therapeutic interest for obesity treatment. The potential of nicotinamide (NAM), the amide form of vitamin B3 and a physiological precursor of nicotinamide adenine dinucleotide (NAD)+, in preventing weight gain has not previously been studied in vivo. Other NAD+ precursors have been shown to decrease weight gain; however, their impact on adipose tissue is not addressed. Methods and results: Two doses of NAM (high dose: 1% and low dose: 0.25%) are given by drinking water to C57BL/6J male mice, starting at the same time as the high-fat diet feeding. NAM supplementation protects against diet-induced obesity by augmenting global body energy expenditure in C57BL/6J male mice. The manipulation markedly alters adipose morphology and metabolism, particularly in inguinal (i) white adipose tissue (iWAT). An increased number of brown and beige adipocyte clusters, protein abundance of uncoupling protein 1 (UCP1), mitochondrial activity, adipose NAD+, and phosphorylated AMP-activated protein kinase (P-AMPK) levels are observed in the iWAT of treated mice. Notably, a significant improvement in hepatic steatosis, inflammation, and glucose tolerance is also observed in NAM high-dose treated mice. Conclusion: NAM influences whole-body energy expenditure by driving changes in the adipose phenotype. Thus, NAM is an attractive potential treatment for preventing obesity and associated complications. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501SMURhttp://purl.org/coar/version/c_71e4c1898caa6e32info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/271568https://dx.doi.org/urn:doi:10.1002/mnfr.202100111reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengFundació la Marató de TV3 https://doi.org/10.13039/100008666 201602.30.31Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00232Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/0164Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01362Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 FI-DGR2014Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CPII18/00004;open accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2715682026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Nicotinamide protects against diet-induced body weight gain, increases energy expenditure, and induces white adipose tissue beiging |
| title |
Nicotinamide protects against diet-induced body weight gain, increases energy expenditure, and induces white adipose tissue beiging |
| spellingShingle |
Nicotinamide protects against diet-induced body weight gain, increases energy expenditure, and induces white adipose tissue beiging Méndez Lara, Karen Alejandra|||0000-0002-8372-2310 Adiposity Beiging Fatty liver Inflammation SDG 3 - Good Health and Well-being |
| title_short |
Nicotinamide protects against diet-induced body weight gain, increases energy expenditure, and induces white adipose tissue beiging |
| title_full |
Nicotinamide protects against diet-induced body weight gain, increases energy expenditure, and induces white adipose tissue beiging |
| title_fullStr |
Nicotinamide protects against diet-induced body weight gain, increases energy expenditure, and induces white adipose tissue beiging |
| title_full_unstemmed |
Nicotinamide protects against diet-induced body weight gain, increases energy expenditure, and induces white adipose tissue beiging |
| title_sort |
Nicotinamide protects against diet-induced body weight gain, increases energy expenditure, and induces white adipose tissue beiging |
| dc.creator.none.fl_str_mv |
Méndez Lara, Karen Alejandra|||0000-0002-8372-2310 Rodríguez-Millán, Elisabeth Sebastián, David|||0000-0002-7260-3869 Blanco-Soto, Rosi Camacho, Mercedes|||0000-0001-5970-3294 Nan, Madalina Nicoleta|||0009-0001-2794-447X Diarte-Añazco, E. M. G.|||0000-0003-3876-9918 Mato, Eugènia|||0000-0001-8121-9335 Lope-Piedrafita, Silvia|||0000-0002-8127-6425 Roglans, Núria Laguna, Joan Carles|||0000-0002-2357-1186 Alonso Pedrol, Núria|||0000-0001-9687-8050 Mauricio, Didac|||0000-0002-2868-0250 Zorzano Olarte, Antonio|||0000-0002-1638-0306 Villarroya, Francesc|||0000-0003-1266-9142 Villena, Josep A.|||0000-0002-2200-2985 Blanco Vaca, Francisco|||0000-0001-7380-5385 Julve i Gil, Josep|||0000-0002-6531-2246 |
| author |
Méndez Lara, Karen Alejandra|||0000-0002-8372-2310 |
| author_facet |
Méndez Lara, Karen Alejandra|||0000-0002-8372-2310 Rodríguez-Millán, Elisabeth Sebastián, David|||0000-0002-7260-3869 Blanco-Soto, Rosi Camacho, Mercedes|||0000-0001-5970-3294 Nan, Madalina Nicoleta|||0009-0001-2794-447X Diarte-Añazco, E. M. G.|||0000-0003-3876-9918 Mato, Eugènia|||0000-0001-8121-9335 Lope-Piedrafita, Silvia|||0000-0002-8127-6425 Roglans, Núria Laguna, Joan Carles|||0000-0002-2357-1186 Alonso Pedrol, Núria|||0000-0001-9687-8050 Mauricio, Didac|||0000-0002-2868-0250 Zorzano Olarte, Antonio|||0000-0002-1638-0306 Villarroya, Francesc|||0000-0003-1266-9142 Villena, Josep A.|||0000-0002-2200-2985 Blanco Vaca, Francisco|||0000-0001-7380-5385 Julve i Gil, Josep|||0000-0002-6531-2246 |
| author_role |
author |
| author2 |
Rodríguez-Millán, Elisabeth Sebastián, David|||0000-0002-7260-3869 Blanco-Soto, Rosi Camacho, Mercedes|||0000-0001-5970-3294 Nan, Madalina Nicoleta|||0009-0001-2794-447X Diarte-Añazco, E. M. G.|||0000-0003-3876-9918 Mato, Eugènia|||0000-0001-8121-9335 Lope-Piedrafita, Silvia|||0000-0002-8127-6425 Roglans, Núria Laguna, Joan Carles|||0000-0002-2357-1186 Alonso Pedrol, Núria|||0000-0001-9687-8050 Mauricio, Didac|||0000-0002-2868-0250 Zorzano Olarte, Antonio|||0000-0002-1638-0306 Villarroya, Francesc|||0000-0003-1266-9142 Villena, Josep A.|||0000-0002-2200-2985 Blanco Vaca, Francisco|||0000-0001-7380-5385 Julve i Gil, Josep|||0000-0002-6531-2246 |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Adiposity Beiging Fatty liver Inflammation SDG 3 - Good Health and Well-being |
| topic |
Adiposity Beiging Fatty liver Inflammation SDG 3 - Good Health and Well-being |
| description |
Scope: Interventions that boost NAD+ availability are of potential therapeutic interest for obesity treatment. The potential of nicotinamide (NAM), the amide form of vitamin B3 and a physiological precursor of nicotinamide adenine dinucleotide (NAD)+, in preventing weight gain has not previously been studied in vivo. Other NAD+ precursors have been shown to decrease weight gain; however, their impact on adipose tissue is not addressed. Methods and results: Two doses of NAM (high dose: 1% and low dose: 0.25%) are given by drinking water to C57BL/6J male mice, starting at the same time as the high-fat diet feeding. NAM supplementation protects against diet-induced obesity by augmenting global body energy expenditure in C57BL/6J male mice. The manipulation markedly alters adipose morphology and metabolism, particularly in inguinal (i) white adipose tissue (iWAT). An increased number of brown and beige adipocyte clusters, protein abundance of uncoupling protein 1 (UCP1), mitochondrial activity, adipose NAD+, and phosphorylated AMP-activated protein kinase (P-AMPK) levels are observed in the iWAT of treated mice. Notably, a significant improvement in hepatic steatosis, inflammation, and glucose tolerance is also observed in NAM high-dose treated mice. Conclusion: NAM influences whole-body energy expenditure by driving changes in the adipose phenotype. Thus, NAM is an attractive potential treatment for preventing obesity and associated complications. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 SMUR http://purl.org/coar/version/c_71e4c1898caa6e32 |
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info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/271568 https://dx.doi.org/urn:doi:10.1002/mnfr.202100111 |
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https://ddd.uab.cat/record/271568 https://dx.doi.org/urn:doi:10.1002/mnfr.202100111 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
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Fundació la Marató de TV3 https://doi.org/10.13039/100008666 201602.30.31 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00232 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/0164 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01362 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 FI-DGR2014 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CPII18/00004; |
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open access http://purl.org/coar/access_right/c_abf2 https://rightsstatements.org/vocab/InC/1.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://rightsstatements.org/vocab/InC/1.0/ |
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openAccess |
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